Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3780
Gene name	Potassium calcium-activated channel subfamily N member 1
Gene symbol	KCNN1
Synonyms (NCBI Gene)	KCa2.1SK1SKCA1hSK1
Chromosome	19
Chromosome location	19p13.11
Summary	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is

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miRTarBase ID	miRNA	Experiments	Reference
MIRT720212	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT720211	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT720210	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT720209	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT720208	hsa-miR-3621	HITS-CLIP	19536157
MIRT638069	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638068	hsa-miR-764	HITS-CLIP	23824327
MIRT638067	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638066	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT638065	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638064	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638063	hsa-miR-4454	HITS-CLIP	23824327
MIRT638062	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT638061	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT532520	hsa-miR-634	PAR-CLIP	22012620
MIRT532519	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532518	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT532517	hsa-miR-4436a	PAR-CLIP	22012620
MIRT532516	hsa-miR-5000-3p	PAR-CLIP	22012620
MIRT532515	hsa-miR-6072	PAR-CLIP	22012620
MIRT532514	hsa-miR-6891-3p	PAR-CLIP	22012620
MIRT532513	hsa-miR-5193	PAR-CLIP	22012620
MIRT532512	hsa-miR-4750-3p	PAR-CLIP	22012620
MIRT532511	hsa-miR-5702	PAR-CLIP	22012620
MIRT532510	hsa-miR-4256	PAR-CLIP	22012620
MIRT532509	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT720212	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT720211	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT720210	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT720209	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT720208	hsa-miR-3621	HITS-CLIP	19536157
MIRT638069	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638068	hsa-miR-764	HITS-CLIP	23824327
MIRT638067	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638066	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT638065	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638064	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638063	hsa-miR-4454	HITS-CLIP	23824327
MIRT638062	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT638061	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT532520	hsa-miR-634	PAR-CLIP	22012620
MIRT532519	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532518	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT532517	hsa-miR-4436a	PAR-CLIP	22012620
MIRT532516	hsa-miR-5000-3p	PAR-CLIP	22012620
MIRT532515	hsa-miR-6072	PAR-CLIP	22012620
MIRT532514	hsa-miR-6891-3p	PAR-CLIP	22012620
MIRT532513	hsa-miR-5193	PAR-CLIP	22012620
MIRT532512	hsa-miR-4750-3p	PAR-CLIP	22012620
MIRT532511	hsa-miR-5702	PAR-CLIP	22012620
MIRT532510	hsa-miR-4256	PAR-CLIP	22012620
MIRT532509	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT1082092	hsa-miR-4707-5p	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2252185	hsa-miR-3926	CLIP-seq
MIRT2252186	hsa-miR-4467	CLIP-seq
MIRT2252187	hsa-miR-4762-5p	CLIP-seq
MIRT2252188	hsa-miR-548s	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005242	Function	Inward rectifier potassium channel activity	IDA	12382077
GO:0005242	Function	Inward rectifier potassium channel activity	IEA
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	TAS	8781233, 9287325, 17142458
GO:0007268	Process	Chemical synaptic transmission	TAS	8781233
GO:0008076	Component	Voltage-gated potassium channel complex	TAS	8781233
GO:0015269	Function	Calcium-activated potassium channel activity	IEA
GO:0015269	Function	Calcium-activated potassium channel activity	TAS	8781233
GO:0016020	Component	Membrane	IEA
GO:0016286	Function	Small conductance calcium-activated potassium channel activity	IBA
GO:0016286	Function	Small conductance calcium-activated potassium channel activity	IDA	8781233, 9287325, 12382077, 17142458
GO:0016286	Function	Small conductance calcium-activated potassium channel activity	IEA
GO:0030018	Component	Z disc	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043025	Component	Neuronal cell body	IBA
GO:0045202	Component	Synapse	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IDA	12382077

MIM	HGNC	e!Ensembl
602982	6290	ENSG00000105642

Q92952

Protein name

Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (hSK1) (KCa2.1)

Protein function

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium all

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03530	SK_channel	92 → 205	Calcium-activated SK potassium channel	Family
PF07885	Ion_trans_2	275 → 370	Ion channel	Family
PF02888	CaMBD	384 → 461	Calmodulin binding domain	Family

Sequence

MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Insulin secretion GnRH secretion		Ca2+ activated K+ channels

KCNN1 (potassium calcium-activated channel subfamily N member 1)