Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3780
Gene name Gene Name - the full gene name approved by the HGNC.	Potassium calcium-activated channel subfamily N member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KCNN1
Synonyms (NCBI Gene) Gene synonyms aliases	KCa2.1, SK1, SKCA1, hSK1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is

Show/Hide all(72)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720212	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT720211	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT720210	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT720209	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT720208	hsa-miR-3621	HITS-CLIP	19536157
MIRT638069	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638068	hsa-miR-764	HITS-CLIP	23824327
MIRT638067	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638066	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT638065	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638064	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638063	hsa-miR-4454	HITS-CLIP	23824327
MIRT638062	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT638061	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT532520	hsa-miR-634	PAR-CLIP	22012620
MIRT532519	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532518	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT532517	hsa-miR-4436a	PAR-CLIP	22012620
MIRT532516	hsa-miR-5000-3p	PAR-CLIP	22012620
MIRT532515	hsa-miR-6072	PAR-CLIP	22012620
MIRT532514	hsa-miR-6891-3p	PAR-CLIP	22012620
MIRT532513	hsa-miR-5193	PAR-CLIP	22012620
MIRT532512	hsa-miR-4750-3p	PAR-CLIP	22012620
MIRT532511	hsa-miR-5702	PAR-CLIP	22012620
MIRT532510	hsa-miR-4256	PAR-CLIP	22012620
MIRT532509	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT720212	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT720211	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT720210	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT720209	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT720208	hsa-miR-3621	HITS-CLIP	19536157
MIRT638069	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638068	hsa-miR-764	HITS-CLIP	23824327
MIRT638067	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638066	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT638065	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638064	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638063	hsa-miR-4454	HITS-CLIP	23824327
MIRT638062	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT638061	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT532520	hsa-miR-634	PAR-CLIP	22012620
MIRT532519	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532518	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT532517	hsa-miR-4436a	PAR-CLIP	22012620
MIRT532516	hsa-miR-5000-3p	PAR-CLIP	22012620
MIRT532515	hsa-miR-6072	PAR-CLIP	22012620
MIRT532514	hsa-miR-6891-3p	PAR-CLIP	22012620
MIRT532513	hsa-miR-5193	PAR-CLIP	22012620
MIRT532512	hsa-miR-4750-3p	PAR-CLIP	22012620
MIRT532511	hsa-miR-5702	PAR-CLIP	22012620
MIRT532510	hsa-miR-4256	PAR-CLIP	22012620
MIRT532509	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT1082092	hsa-miR-4707-5p	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2252185	hsa-miR-3926	CLIP-seq
MIRT2252186	hsa-miR-4467	CLIP-seq
MIRT2252187	hsa-miR-4762-5p	CLIP-seq
MIRT2252188	hsa-miR-548s	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq
MIRT2020423	hsa-miR-214	CLIP-seq
MIRT2020424	hsa-miR-3619-5p	CLIP-seq
MIRT2020425	hsa-miR-3665	CLIP-seq
MIRT2020426	hsa-miR-3907	CLIP-seq
MIRT2020427	hsa-miR-761	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Ion transport	IBA	21873635
GO:0006813	Process	Potassium ion transport	TAS	8781233
GO:0007268	Process	Chemical synaptic transmission	TAS	8781233
GO:0008076	Component	Voltage-gated potassium channel complex	TAS	8781233
GO:0015269	Function	Calcium-activated potassium channel activity	TAS	8781233
GO:0016286	Function	Small conductance calcium-activated potassium channel activity	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043025	Component	Neuronal cell body	IBA	21873635
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635

MIM	HGNC	e!Ensembl
602982	6290	ENSG00000105642

Protein

UniProt ID

Q92952

Protein name

Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (hSK1) (KCa2.1)

Protein function

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium all

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03530	SK_channel	92 → 205	Calcium-activated SK potassium channel	Family
PF07885	Ion_trans_2	275 → 370	Ion channel	Family
PF02888	CaMBD	384 → 461	Calmodulin binding domain	Family

Sequence

MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Insulin secretion GnRH secretion		Ca2+ activated K+ channels

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	37831636
Carcinogenesis	Associate	37831636
Glioma	Associate	16817201
Neoplasm Metastasis	Associate	37831636
Neoplasms	Associate	16817201
Neuralgia	Associate	37012681
Obesity	Associate	29132311

KCNN1 (potassium calcium-activated channel subfamily N member 1)