Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3772
Gene name	Potassium inwardly rectifying channel subfamily J member 15
Gene symbol	KCNJ15
Synonyms (NCBI Gene)	IRKKKIR1.3KIR4.2
Chromosome	21
Chromosome location	21q22.13-q22.2
Summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has

Show/Hide all (80)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021341	hsa-miR-9-5p	Microarray	17612493
MIRT027409	hsa-miR-98-5p	Microarray	19088304
MIRT687805	hsa-miR-548ac	HITS-CLIP	23313552
MIRT687804	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT687803	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT687802	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT687801	hsa-miR-548z	HITS-CLIP	23313552
MIRT687800	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT687799	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT687798	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT687797	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT687796	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT687795	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT687794	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT687793	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT687792	hsa-miR-433-5p	HITS-CLIP	23313552
MIRT687791	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT687790	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT687789	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT687805	hsa-miR-548ac	HITS-CLIP	23313552
MIRT687804	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT687803	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT687802	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT687801	hsa-miR-548z	HITS-CLIP	23313552
MIRT687800	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT687799	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT687798	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT687797	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT687796	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT687795	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT687794	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT687793	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT687792	hsa-miR-433-5p	HITS-CLIP	23313552
MIRT687791	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT687790	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT687789	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT569800	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT569799	hsa-miR-298	PAR-CLIP	20371350
MIRT569798	hsa-miR-498	PAR-CLIP	20371350
MIRT1081431	hsa-miR-1	CLIP-seq
MIRT1081432	hsa-miR-1909	CLIP-seq
MIRT1081433	hsa-miR-206	CLIP-seq
MIRT1081434	hsa-miR-3673	CLIP-seq
MIRT1081435	hsa-miR-500a	CLIP-seq
MIRT1081436	hsa-miR-613	CLIP-seq
MIRT1922162	hsa-miR-3157-3p	CLIP-seq
MIRT1922163	hsa-miR-874	CLIP-seq
MIRT2020175	hsa-miR-2113	CLIP-seq
MIRT2020176	hsa-miR-218	CLIP-seq
MIRT2252002	hsa-miR-3190	CLIP-seq
MIRT2252003	hsa-miR-4261	CLIP-seq
MIRT2252004	hsa-miR-4491	CLIP-seq
MIRT2252005	hsa-miR-4657	CLIP-seq
MIRT2438097	hsa-miR-1264	CLIP-seq
MIRT2438098	hsa-miR-1302	CLIP-seq
MIRT2438099	hsa-miR-149	CLIP-seq
MIRT2438100	hsa-miR-3064-5p	CLIP-seq
MIRT2438101	hsa-miR-3607-3p	CLIP-seq
MIRT2438102	hsa-miR-3652	CLIP-seq
MIRT2438103	hsa-miR-3686	CLIP-seq
MIRT2438104	hsa-miR-4298	CLIP-seq
MIRT2438105	hsa-miR-4430	CLIP-seq
MIRT2438106	hsa-miR-4505	CLIP-seq
MIRT2438107	hsa-miR-4794	CLIP-seq
MIRT2438108	hsa-miR-580	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005242	Function	Inward rectifier potassium channel activity	IBA
GO:0005242	Function	Inward rectifier potassium channel activity	IEA
GO:0005242	Function	Inward rectifier potassium channel activity	TAS	8995301
GO:0005267	Function	Potassium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	9647694, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8995301
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	TAS	8995301
GO:0016020	Component	Membrane	IEA
GO:0030001	Process	Metal ion transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0034765	Process	Regulation of monoatomic ion transmembrane transport	IBA
GO:1990573	Process	Potassium ion import across plasma membrane	IBA

MIM	HGNC	e!Ensembl
602106	6261	ENSG00000157551

Q99712

Protein name

ATP-sensitive inward rectifier potassium channel 15 (Inward rectifier K(+) channel Kir1.3) (Inward rectifier K(+) channel Kir4.2) (Potassium channel, inwardly rectifying subfamily J member 15)

Protein function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potass

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01007	IRK	30 → 171	Inward rectifier potassium channel transmembrane domain	Domain
PF17655	IRK_C	178 → 350	Inward rectifier potassium channel C-terminal domain	Domain

Sequence

MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVID
MKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLF
SLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKF
SHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD
SSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSY
IPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQ
RERELRTLLLQQSNV

Sequence length

375

Interactions

View interactions

	KEGG		Reactome
	Gastric acid secretion		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

KCNJ15 (potassium inwardly rectifying channel subfamily J member 15)