NRROS (negative regulator of reactive oxygen species)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
375387
Gene name Gene Name - the full gene name approved by the HGNC.
Negative regulator of reactive oxygen species
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NRROS
Synonyms (NCBI Gene) Gene synonyms aliases
ELLP3030, GARPL1, LRRC33, SENEBAC, UNQ3030
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SENEBAC
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region IEA
GO:0005783 Component Endoplasmic reticulum ISS
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005886 Component Plasma membrane IEA
GO:0006801 Process Superoxide metabolic process ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
615322 24613 ENSG00000174004
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q86YC3
Protein name Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
Protein function Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 81 → 144 Leucine rich repeat Repeat
PF13855 LRR_8 157 → 217 Leucine rich repeat Repeat
PF13855 LRR_8 328 → 388 Leucine rich repeat Repeat
PF13516 LRR_6 424 → 440 Leucine Rich repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in cells of hematopoietic origin (PubMed:29909984). Highly expressed in bone marrow, thymus, liver, lung, intestine and spleen (PubMed:23545260). In the brain, highly expressed in microglia (PubMed:32100099). {ECO:0000
Sequence 
MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHAR
MLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSEN
YEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGL
ERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEW
FLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMV
AQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLH
QNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPG
LFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDC
PFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRD
LDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCG
VDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSC
LTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY
Sequence length 692
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  TGF-beta signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 29785011 ClinVar, GWAS
Eczema Eczema GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Baraitser Brett Piesowicz syndrome Associate 32197075
Calcinosis Associate 35099671
Drug Resistant Epilepsy Associate 32197075
Fahr's disease Associate 35099671
Inflammation Associate 32197075
Leukemia Myeloid Acute Associate 31600200
Mitochondrial Diseases Associate 35099671
Neoplasms Associate 31600200
Neurodegenerative Diseases Associate 32197075, 35099671
Paroxysmal ventricular fibrillation Associate 37239478