GSTK1 (glutathione S-transferase kappa 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
373156
Gene name Gene Name - the full gene name approved by the HGNC.
Glutathione S-transferase kappa 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSTK1
Synonyms (NCBI Gene) Gene synonyms aliases
GST, GST 13-13, GST13, GST13-13, GSTK1-1, hGSTK1
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q34
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range o
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(62)
miRTarBase ID miRNA Experiments Reference
MIRT022421 hsa-miR-124-3p Microarray 18668037
MIRT048157 hsa-miR-196a-5p CLASH 23622248
MIRT516744 hsa-miR-6890-5p PAR-CLIP 23446348
MIRT516743 hsa-miR-1273f PAR-CLIP 23446348
MIRT516742 hsa-miR-8069 PAR-CLIP 23446348
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA 21873635
GO:0004364 Function Glutathione transferase activity IDA 14742434
GO:0004602 Function Glutathione peroxidase activity IBA 21873635
GO:0004602 Function Glutathione peroxidase activity IDA 14742434
GO:0005515 Function Protein binding IPI 19011089, 22583869, 25416956, 31515488
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602321 16906 ENSG00000197448
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y2Q3
Protein name Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13)
Protein function Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed:14709161, PubMed:14742434). Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-d
PDB 1YZX , 3RPN , 3RPP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01323 DSBA 7 → 211 DSBA-like thioredoxin domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:14742434}.
Sequence
Sequence length 226
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Peroxisome
Chemical carcinogenesis - DNA adducts 		  Glutathione conjugation
Peroxisomal protein import
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Show/Hide Text Mining Associations (163)
Associations from Text Mining
Disease Name Relationship Type References
Acute Chest Syndrome Associate 25880856
Adenocarcinoma Inhibit 17278189
Alzheimer Disease Associate 15985314, 21640828, 37772794
Anemia Aplastic Associate 11719393
Anemia Hemolytic Associate 16173971
Anemia Sickle Cell Associate 25880856
Aortic Aneurysm Thoracic Associate 32273946
Ascorbic Acid Deficiency Associate 19710200
Asthma Associate 15223862, 18057098, 20367187, 21109554, 22812193
Ataxia Associate 9077484