JARID2 (jumonji and AT-rich interaction domain containing 2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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3720 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Jumonji and AT-rich interaction domain containing 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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JARID2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DIDDF, JMJ |
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Chromosome
Chromosome number
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6 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6p22.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q92833 | |||||||||||||||||||||||||
| Protein name | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | |||||||||||||||||||||||||
| Protein function | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the c | |||||||||||||||||||||||||
| PDB | 4X3E , 5HYN , 5LS6 , 5WAI , 6C23 , 6C24 , 6NQ3 , 6WKR , 7KSO , 8TB9 , 8VMI , 8VML , 8VNV , 8VNZ , 9C8U , 9DCH | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells. | |||||||||||||||||||||||||
| Sequence |
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| Sequence length | 1246 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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