Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3714
Gene name	Jagged canonical Notch ligand 2
Gene symbol	JAG2
Synonyms (NCBI Gene)	HJ2LGMDR27SER2
Chromosome	14
Chromosome location	14q32.33
Summary	The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded

140

Show/Hide all (140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016805	hsa-miR-335-5p	Microarray	18185580
MIRT022161	hsa-miR-124-3p	Microarray	18668037
MIRT049515	hsa-miR-92a-3p	CLASH	23622248
MIRT042161	hsa-miR-484	CLASH	23622248
MIRT053421	hsa-miR-624-3p	Microarray	23807165
MIRT647293	hsa-miR-6165	HITS-CLIP	23824327
MIRT647292	hsa-miR-8083	HITS-CLIP	23824327
MIRT647291	hsa-miR-214-3p	HITS-CLIP	23824327
MIRT647290	hsa-miR-3619-5p	HITS-CLIP	23824327
MIRT647289	hsa-miR-761	HITS-CLIP	23824327
MIRT647288	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT647287	hsa-miR-1286	HITS-CLIP	23824327
MIRT647286	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT647285	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT647284	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT647283	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT647282	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT647281	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT647280	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT647278	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT647279	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT731729	hsa-miR-410-3p	ImmunofluorescenceMicroarrayqRT-PCRWestern blot	25998143
MIRT731729	hsa-miR-410-3p	ImmunofluorescenceMicroarrayqRT-PCRWestern blot	25998143
MIRT647293	hsa-miR-6165	HITS-CLIP	23824327
MIRT647292	hsa-miR-8083	HITS-CLIP	23824327
MIRT647291	hsa-miR-214-3p	HITS-CLIP	23824327
MIRT647290	hsa-miR-3619-5p	HITS-CLIP	23824327
MIRT647289	hsa-miR-761	HITS-CLIP	23824327
MIRT647288	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT647287	hsa-miR-1286	HITS-CLIP	23824327
MIRT647286	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT647285	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT647284	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT647283	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT647282	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT647281	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT647280	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT647278	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT647279	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT1075945	hsa-miR-1227	CLIP-seq
MIRT1075946	hsa-miR-2115	CLIP-seq
MIRT1075947	hsa-miR-3671	CLIP-seq
MIRT1075948	hsa-miR-4517	CLIP-seq
MIRT1075949	hsa-miR-4643	CLIP-seq
MIRT1075950	hsa-miR-466	CLIP-seq
MIRT1075951	hsa-miR-4789-3p	CLIP-seq
MIRT1075952	hsa-miR-4797-5p	CLIP-seq
MIRT1075953	hsa-miR-485-3p	CLIP-seq
MIRT1075954	hsa-miR-516a-3p	CLIP-seq
MIRT1075955	hsa-miR-520d-5p	CLIP-seq
MIRT1075956	hsa-miR-520f	CLIP-seq
MIRT1075957	hsa-miR-524-5p	CLIP-seq
MIRT1075958	hsa-miR-759	CLIP-seq
MIRT1075959	hsa-miR-889	CLIP-seq
MIRT1075960	hsa-miR-1224-3p	CLIP-seq
MIRT1075961	hsa-miR-1229	CLIP-seq
MIRT1075962	hsa-miR-1256	CLIP-seq
MIRT1075963	hsa-miR-1260	CLIP-seq
MIRT1075964	hsa-miR-1260b	CLIP-seq
MIRT1075965	hsa-miR-1280	CLIP-seq
MIRT1075966	hsa-miR-136	CLIP-seq
MIRT1075967	hsa-miR-148a	CLIP-seq
MIRT1075968	hsa-miR-148b	CLIP-seq
MIRT1075969	hsa-miR-152	CLIP-seq
MIRT1075970	hsa-miR-193a-5p	CLIP-seq
MIRT1075946	hsa-miR-2115	CLIP-seq
MIRT1075971	hsa-miR-30a	CLIP-seq
MIRT1075972	hsa-miR-30b	CLIP-seq
MIRT1075973	hsa-miR-30c	CLIP-seq
MIRT1075974	hsa-miR-30d	CLIP-seq
MIRT1075975	hsa-miR-30e	CLIP-seq
MIRT1075976	hsa-miR-3145-5p	CLIP-seq
MIRT1075977	hsa-miR-3157-5p	CLIP-seq
MIRT1075978	hsa-miR-3607-3p	CLIP-seq
MIRT1075947	hsa-miR-3671	CLIP-seq
MIRT1075979	hsa-miR-3686	CLIP-seq
MIRT1075980	hsa-miR-3918	CLIP-seq
MIRT1075981	hsa-miR-4272	CLIP-seq
MIRT1075948	hsa-miR-4517	CLIP-seq
MIRT1075982	hsa-miR-4640-5p	CLIP-seq
MIRT1075949	hsa-miR-4643	CLIP-seq
MIRT1075950	hsa-miR-466	CLIP-seq
MIRT1075983	hsa-miR-4685-5p	CLIP-seq
MIRT1075984	hsa-miR-4691-3p	CLIP-seq
MIRT1075985	hsa-miR-4699-5p	CLIP-seq
MIRT1075986	hsa-miR-4705	CLIP-seq
MIRT1075987	hsa-miR-4726-5p	CLIP-seq
MIRT1075988	hsa-miR-4778-5p	CLIP-seq
MIRT1075951	hsa-miR-4789-3p	CLIP-seq
MIRT1075952	hsa-miR-4797-5p	CLIP-seq
MIRT1075989	hsa-miR-508-5p	CLIP-seq
MIRT1075954	hsa-miR-516a-3p	CLIP-seq
MIRT1075955	hsa-miR-520d-5p	CLIP-seq
MIRT1075956	hsa-miR-520f	CLIP-seq
MIRT1075957	hsa-miR-524-5p	CLIP-seq
MIRT1075958	hsa-miR-759	CLIP-seq
MIRT1075959	hsa-miR-889	CLIP-seq
MIRT2018850	hsa-miR-124	CLIP-seq
MIRT2018851	hsa-miR-151-5p	CLIP-seq
MIRT2018852	hsa-miR-151b	CLIP-seq
MIRT2018853	hsa-miR-200b	CLIP-seq
MIRT2018854	hsa-miR-200c	CLIP-seq
MIRT1075946	hsa-miR-2115	CLIP-seq
MIRT2018855	hsa-miR-300	CLIP-seq
MIRT2018856	hsa-miR-3135b	CLIP-seq
MIRT2018857	hsa-miR-3138	CLIP-seq
MIRT2018858	hsa-miR-3180	CLIP-seq
MIRT2018859	hsa-miR-3180-3p	CLIP-seq
MIRT2018860	hsa-miR-3184	CLIP-seq
MIRT2018861	hsa-miR-3196	CLIP-seq
MIRT2018862	hsa-miR-3611	CLIP-seq
MIRT2018863	hsa-miR-3660	CLIP-seq
MIRT1075947	hsa-miR-3671	CLIP-seq
MIRT2018864	hsa-miR-381	CLIP-seq
MIRT2018865	hsa-miR-423-5p	CLIP-seq
MIRT2018866	hsa-miR-429	CLIP-seq
MIRT2018867	hsa-miR-4427	CLIP-seq
MIRT2018868	hsa-miR-4493	CLIP-seq
MIRT2018869	hsa-miR-4520a-3p	CLIP-seq
MIRT2018870	hsa-miR-4526	CLIP-seq
MIRT2018871	hsa-miR-4645-3p	CLIP-seq
MIRT2018872	hsa-miR-4666-3p	CLIP-seq
MIRT1075986	hsa-miR-4705	CLIP-seq
MIRT2018873	hsa-miR-4724-5p	CLIP-seq
MIRT2018874	hsa-miR-4736	CLIP-seq
MIRT2018875	hsa-miR-4737	CLIP-seq
MIRT2018876	hsa-miR-4767	CLIP-seq
MIRT2018877	hsa-miR-4779	CLIP-seq
MIRT2018878	hsa-miR-4789-5p	CLIP-seq
MIRT1075952	hsa-miR-4797-5p	CLIP-seq
MIRT1075953	hsa-miR-485-3p	CLIP-seq
MIRT2018879	hsa-miR-506	CLIP-seq
MIRT1075954	hsa-miR-516a-3p	CLIP-seq
MIRT1075955	hsa-miR-520d-5p	CLIP-seq
MIRT1075956	hsa-miR-520f	CLIP-seq
MIRT1075957	hsa-miR-524-5p	CLIP-seq
MIRT1075958	hsa-miR-759	CLIP-seq
MIRT2018880	hsa-miR-935	CLIP-seq
MIRT1075977	hsa-miR-3157-5p	CLIP-seq
MIRT1075984	hsa-miR-4691-3p	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0003016	Process	Respiratory system process	IEA
GO:0005112	Function	Notch binding	IBA
GO:0005112	Function	Notch binding	IEA
GO:0005112	Function	Notch binding	IPI	9315665
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16713569
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS	10910909
GO:0005886	Component	Plasma membrane	TAS
GO:0007154	Process	Cell communication	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007219	Process	Notch signaling pathway	NAS	11056013
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEP	11700865
GO:0008083	Function	Growth factor activity	IDA	10383933
GO:0009912	Process	Auditory receptor cell fate commitment	IEA
GO:0009912	Process	Auditory receptor cell fate commitment	ISS	10080181
GO:0016020	Component	Membrane	IEA
GO:0016331	Process	Morphogenesis of embryonic epithelium	IEA
GO:0030154	Process	Cell differentiation	IDA	11700865
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0030217	Process	T cell differentiation	IDA	10383933
GO:0042127	Process	Regulation of cell population proliferation	IDA	10383933
GO:0042475	Process	Odontogenesis of dentin-containing tooth	IEA
GO:0042492	Process	Gamma-delta T cell differentiation	IEA
GO:0045061	Process	Thymic T cell selection	IDA	10383933
GO:0045747	Process	Positive regulation of Notch signaling pathway	IEA
GO:0045747	Process	Positive regulation of Notch signaling pathway	ISS
GO:1990134	Process	Epithelial cell apoptotic process involved in palatal shelf morphogenesis	IEA

MIM	HGNC	e!Ensembl
602570	6189	ENSG00000184916

Q9Y219

Protein name

Protein jagged-2 (Jagged2) (hJ2)

Protein function

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

PDB

5MW5 , 5MW7 , 5MWF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07657	MNNL	27 → 103	N terminus of Notch ligand	Family
PF01414	DSL	178 → 240	Delta serrate ligand	Domain
PF00008	EGF	311 → 343	EGF-like domain	Domain
PF00008	EGF	351 → 381	EGF-like domain	Domain
PF00008	EGF	389 → 419	EGF-like domain	Domain
PF07645	EGF_CA	423 → 465	Calcium-binding EGF domain	Domain
PF12661	hEGF	469 → 490	Human growth factor-like EGF	Domain
PF12661	hEGF	507 → 528	Human growth factor-like EGF	Domain
PF12661	hEGF	606 → 628	Human growth factor-like EGF	Domain
PF00008	EGF	640 → 670	EGF-like domain	Domain
PF00008	EGF	678 → 708	EGF-like domain	Domain
PF00008	EGF	716 → 746	EGF-like domain	Domain
PF00008	EGF	755 → 785	EGF-like domain	Domain
PF00008	EGF	793 → 823	EGF-like domain	Domain
PF00008	EGF	831 → 861	EGF-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.

Sequence

MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC
KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG
SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC
QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN
GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC
EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT
AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG
WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA
TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD
CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL
PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG
ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST
GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER
PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK
FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Sequence length

1238

Interactions

View interactions

	KEGG		Reactome
	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Pathways in cancer Breast cancer		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Activation and Transmission of Signal to the Nucleus

103

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Muscular dystrophy, limb-girdle, autosomal recessive 27	Likely pathogenic; Pathogenic	rs781734780, rs2140979845, rs1377648342, rs751347948, rs1426938760	RCV001731214 RCV002074459 RCV002074460 RCV002223156 RCV003989928

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign; Likely benign	rs146366402, rs117007108	RCV005913442 RCV005904468
Colon adenocarcinoma	Benign; Likely benign	rs146366402	RCV005913441
Familial cancer of breast	Benign	rs117007108	RCV005904465
Gastric cancer	Benign	rs112948395	RCV005933215
Hepatocellular carcinoma	Benign	rs117007108	RCV005904466
JAG2-related disorder	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs774914201, rs202178182, rs2542878179, rs200439518, rs142729116, rs770756112, rs768876569, rs202039687, rs181385226, rs771494301, rs3122382, rs376316136, rs373302058, rs78154277, rs368232652 View all (45 more)	RCV003391379 RCV003414584 RCV003400095 RCV003906751 RCV003929053 RCV003896653 RCV003894548 RCV003921508 RCV003924078 RCV003894180 RCV003906869 RCV003904510 RCV003974288 RCV003979871 RCV003901735 RCV003903961 RCV003917002 RCV003911604 RCV003909586 RCV003933977 RCV003941957 RCV003944077 RCV003961683 RCV003961707 RCV003959559 RCV003931581 RCV003927166 RCV003939441 RCV003914324 RCV003947091 RCV003949409 RCV003949472 RCV003944394 RCV003957045 RCV003926812 RCV003932097 RCV003934087 RCV003934159 RCV003957375 RCV003957376 RCV003959405 RCV003959464 RCV003971667 RCV003971765 RCV003967096 RCV003964236 RCV003976411 RCV003935854 RCV003978360 RCV003905994 RCV003936039 RCV003918404 RCV003928577 RCV003930644 RCV003930681 RCV003968042 RCV003930794 RCV003920667 RCV003975718 RCV003923248
Lung cancer	Benign	rs112948395	RCV005933216
Malignant tumor of esophagus	Likely benign; Benign	rs376316136, rs112948395, rs117007108	RCV005936896 RCV005933214 RCV005904467
Mendelian syndromes with cleft lip/palate	Uncertain significance	rs1888180630	RCV003315098
Orofacial cleft 1	Conflicting classifications of pathogenicity	rs78154277	RCV005871474
Sarcoma	Benign; Likely benign	rs146366402	RCV005913443
Uterine corpus endometrial carcinoma	Benign; Likely benign	rs146366402	RCV005913444

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	16136053, 27196489
Adenocarcinoma of Lung	Associate	27196489
Anxiety	Associate	29225348
Arthritis Rheumatoid	Associate	37796367
Breast Neoplasms	Stimulate	20030805
Breast Neoplasms	Associate	21499308, 21990379
Calcinosis Cutis	Stimulate	25576913
Carcinogenesis	Associate	32250571
Carcinoma	Associate	24708907
Carcinoma Pancreatic Ductal	Stimulate	21922151
Chromosome 1q21.1 Deletion Syndrome 1.35 Mb	Associate	24708907
Cleft Lip	Associate	16327884
Cleft Palate	Associate	16327884
Colorectal Neoplasms	Associate	26744411
Endocrine System Diseases	Associate	37796700
Glioblastoma	Associate	21129727, 21649900
Histiocytosis Langerhans Cell	Associate	23074278
Huntington Disease	Associate	25480889
Hypoxia	Stimulate	21499308, 25166211
Hypoxia Brain	Stimulate	21499308
Inflammation	Associate	19398556
Leukemia Lymphocytic Chronic B Cell	Associate	18796623
Medulloblastoma	Associate	24708907, 25576913
Monoclonal Gammopathy of Undetermined Significance	Stimulate	15292061
Multiple Myeloma	Associate	15292061, 15920166, 37834003
Neoplasm Metastasis	Associate	21499308, 23211831
Neoplasm Metastasis	Stimulate	24228105
Neoplasms	Stimulate	20030805
Neoplasms	Associate	21499308, 21922151, 21990379, 23211831, 24228105, 30280784, 32250571, 37834003
Neurodegenerative Diseases	Associate	25480889
Osteosarcoma	Associate	33926256
Ovarian Neoplasms	Associate	20624166, 37796700
Pancreatic Neoplasms	Associate	19258443
Prostatic Intraepithelial Neoplasia	Associate	26341090
Prostatic Neoplasms Castration Resistant	Associate	27068475
Retinoblastoma	Associate	27661116
Skin Neoplasms	Stimulate	25565632
Squamous Cell Carcinoma of Head and Neck	Associate	24351288, 32250571
Squamous Cell Carcinoma of Head and Neck	Stimulate	27349552
Stomach Neoplasms	Associate	36071128
Testicular Germ Cell Tumor	Associate	15361705
Triple Negative Breast Neoplasms	Associate	30280784
Urinary Bladder Neoplasms	Associate	24228105
Uveal melanoma	Associate	23211831

JAG2 (jagged canonical Notch ligand 2)