ITPKA (inositol-trisphosphate 3-kinase A)

Gene

• Entrez ID: 3706
• Gene name: Inositol-trisphosphate 3-kinase A
• Gene symbol: ITPKA
• Synonyms (NCBI Gene): IP3-3KA, IP3KA
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016467	hsa-miR-193b-3p	Microarray	20304954
MIRT1074802	hsa-miR-1289	CLIP-seq
MIRT1074803	hsa-miR-129-3p	CLIP-seq
MIRT1074804	hsa-miR-3121-5p	CLIP-seq
MIRT1074805	hsa-miR-3127-3p	CLIP-seq
MIRT1074806	hsa-miR-3185	CLIP-seq
MIRT1074807	hsa-miR-4313	CLIP-seq
MIRT1074808	hsa-miR-4433	CLIP-seq
MIRT1074809	hsa-miR-4706	CLIP-seq
MIRT1074810	hsa-miR-4749-5p	CLIP-seq
MIRT1074802	hsa-miR-1289	CLIP-seq
MIRT1074808	hsa-miR-4433	CLIP-seq
MIRT1074809	hsa-miR-4706	CLIP-seq
MIRT1074810	hsa-miR-4749-5p	CLIP-seq
MIRT2389518	hsa-miR-146b-3p	CLIP-seq
MIRT2389519	hsa-miR-3130-3p	CLIP-seq
MIRT2389520	hsa-miR-3173-5p	CLIP-seq
MIRT2389521	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IBA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IDA	1847047
GO:0005856	Component	Cytoskeleton	IEA
GO:0006020	Process	Inositol metabolic process	IEA
GO:0007165	Process	Signal transduction	TAS	1847047, 2176078
GO:0008440	Function	Inositol-1,4,5-trisphosphate 3-kinase activity	IDA	1847047, 12747803
GO:0008440	Function	Inositol-1,4,5-trisphosphate 3-kinase activity	IEA
GO:0008440	Function	Inositol-1,4,5-trisphosphate 3-kinase activity	TAS	1654894
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0032958	Process	Inositol phosphate biosynthetic process	IBA
GO:0032958	Process	Inositol phosphate biosynthetic process	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IDA	1847047, 12747803
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0051592	Process	Response to calcium ion	IDA	1847047
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0071277	Process	Cellular response to calcium ion	IDA	12747803
GO:0071277	Process	Cellular response to calcium ion	IEA
GO:0097062	Process	Dendritic spine maintenance	IEA
GO:0098871	Component	Postsynaptic actin cytoskeleton	IEA
GO:0098885	Process	Modification of postsynaptic actin cytoskeleton	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 147521
• HGNC: 6178
• e!Ensembl: ENSG00000137825

Protein

• UniProt ID: P23677
• Protein name: Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)
• Protein function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO
• PDB: 1W2C, 1W2D, 1W2F, 4UPU, 8PP8, 8PP9, 8PPA, 8PPB, 8PPC, 8PPD, 8PPE, 8PPF, 8PPG, 8PPH, 8PPI, 8PPJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03770	IPK	245 → 456	Inositol polyphosphate kinase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:1847047}.
• Sequence:

  MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
  RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
  STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
  PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
  DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
  TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
  EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
  TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

• Sequence length: 461

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Calcium signaling pathway
Phosphatidylinositol signaling system

Reactome:

Synthesis of IP3 and IP4 in the cytosol