Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3685
Gene name Gene Name - the full gene name approved by the HGNC.
Integrin subunit alpha V
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ITGAV
Synonyms (NCBI Gene) Gene synonyms aliases
CD51, MSK8, VNRA, VTNR
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021641 hsa-miR-142-3p Microarray 17612493
MIRT024872 hsa-miR-215-5p Microarray 19074876
MIRT026088 hsa-miR-196a-5p Sequencing 20371350
MIRT026587 hsa-miR-192-5p Microarray 19074876
MIRT028372 hsa-miR-32-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
FOSL1 Repression 23319049
HOXD3 Unknown 14610084
JUND Repression 23319049
SP1 Repression 23319049
SP1 Unknown 12136940
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEP 11866539
GO:0001570 Process Vasculogenesis IEA
GO:0001618 Function Virus receptor activity IEA
GO:0001846 Function Opsonin binding ISS
GO:0001968 Function Fibronectin binding IDA 24658351
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
193210 6150 ENSG00000138448
Protein
UniProt ID P06756
Protein name Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Protein function The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide ar
PDB 1JV2 , 1L5G , 1M1X , 1U8C , 3IJE , 4G1E , 4G1M , 4MMX , 4MMY , 4MMZ , 4O02 , 4UM8 , 4UM9 , 5FFG , 5FFO , 5NEM , 5NER , 5NET , 5NEU , 6AVQ , 6AVR , 6AVU , 6DJP , 6MK0 , 6MSL , 6MSU , 6NAJ , 6OM1 , 6OM2 , 6UJA , 6UJB , 6UJC , 7Y1T , 8IJ5 , 8TCF , 8TCG , 8VS6 , 8VSD , 8W30 , 8XEI , 8XEK , 8XEL , 8XEN , 8XER , 8XEZ , 8XF6 , 8XFG , 8XFO , 9CZ7 , 9CZA , 9CZD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01839 FG-GAP 252 286 FG-GAP repeat Repeat
PF01839 FG-GAP 306 348 FG-GAP repeat Repeat
PF01839 FG-GAP 370 406 FG-GAP repeat Repeat
PF08441 Integrin_alpha2 467 914 Integrin alpha Family
PF00357 Integrin_alpha 1017 1031 Integrin alpha cytoplasmic region Family
Sequence
MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSA
SSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKS
HQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD
GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLAT
RTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGE
QMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTK
LNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQI
LEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY
PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRR
ALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAAD
TTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVK
AQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAG
TQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSP
DHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLY
ILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIH
TLGCGVAQCLKIVC
QVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIE
FPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGF
FKRVRPPQEEQ
EREQLQPHENGEGNSET
Sequence length 1048
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Hormone signaling
Phagosome
Efferocytosis
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Thyroid hormone signaling pathway
Human cytomegalovirus infection
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy
Fluid shear stress and atherosclerosis
  Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Crohn Disease Crohn Disease GWAS
Dyslexia Dyslexia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acro Osteolysis Stimulate 19369175
Adenocarcinoma Associate 33110104
Adenoma Associate 26749005
Aortic Root Aneurysm Stimulate 33230159
Apical Hypertrophic Cardiomyopathy Stimulate 35328555
Arteriovenous Malformations Associate 31519800
Arthritis Rheumatoid Associate 15345499, 17615072, 25150077, 28376277
Atherosclerosis Associate 12099514, 24412187
Bone Cysts Aneurysmal Associate 22330339
Brain Neoplasms Associate 25093246, 26689941, 29053416