Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	366
Gene name Gene Name - the full gene name approved by the HGNC.	Aquaporin 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AQP9
Synonyms (NCBI Gene) Gene synonyms aliases	AQP-9, HsT17287, SSC1, T17287
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and

Show/Hide all(188)

miRTarBase ID	miRNA	Experiments
MIRT791576	hsa-miR-18a	CLIP-seq
MIRT791577	hsa-miR-18b	CLIP-seq
MIRT791578	hsa-miR-300	CLIP-seq
MIRT791579	hsa-miR-3136-5p	CLIP-seq
MIRT791580	hsa-miR-324-5p	CLIP-seq
MIRT791581	hsa-miR-381	CLIP-seq
MIRT791582	hsa-miR-4439	CLIP-seq
MIRT791583	hsa-miR-4513	CLIP-seq
MIRT791584	hsa-miR-4645-3p	CLIP-seq
MIRT791585	hsa-miR-4666-3p	CLIP-seq
MIRT791586	hsa-miR-4712-5p	CLIP-seq
MIRT791587	hsa-miR-4735-3p	CLIP-seq
MIRT791588	hsa-miR-4789-5p	CLIP-seq
MIRT791589	hsa-miR-493	CLIP-seq
MIRT791590	hsa-miR-514	CLIP-seq
MIRT791591	hsa-miR-514b-3p	CLIP-seq
MIRT791592	hsa-miR-770-5p	CLIP-seq
MIRT791593	hsa-miR-943	CLIP-seq
MIRT1920265	hsa-miR-224	CLIP-seq
MIRT1920266	hsa-miR-4803	CLIP-seq
MIRT1920267	hsa-miR-494	CLIP-seq
MIRT1933501	hsa-miR-3155	CLIP-seq
MIRT1933502	hsa-miR-3155b	CLIP-seq
MIRT1933503	hsa-miR-4694-3p	CLIP-seq
MIRT1933504	hsa-miR-484	CLIP-seq
MIRT1933505	hsa-miR-522	CLIP-seq
MIRT1933506	hsa-miR-548c-3p	CLIP-seq
MIRT1933507	hsa-miR-587	CLIP-seq
MIRT1933508	hsa-miR-885-5p	CLIP-seq
MIRT2173577	hsa-miR-1207-5p	CLIP-seq
MIRT2173578	hsa-miR-3065-3p	CLIP-seq
MIRT2173579	hsa-miR-3074-3p	CLIP-seq
MIRT2173580	hsa-miR-3153	CLIP-seq
MIRT2173581	hsa-miR-330-3p	CLIP-seq
MIRT2173582	hsa-miR-3907	CLIP-seq
MIRT2173583	hsa-miR-4259	CLIP-seq
MIRT2173584	hsa-miR-4425	CLIP-seq
MIRT2173585	hsa-miR-4668-5p	CLIP-seq
MIRT2173586	hsa-miR-4736	CLIP-seq
MIRT2173587	hsa-miR-4763-3p	CLIP-seq
MIRT2477160	hsa-miR-1263	CLIP-seq
MIRT2477161	hsa-miR-1270	CLIP-seq
MIRT2477162	hsa-miR-1301	CLIP-seq
MIRT2477163	hsa-miR-130a	CLIP-seq
MIRT2477164	hsa-miR-130b	CLIP-seq
MIRT2477165	hsa-miR-151-5p	CLIP-seq
MIRT2477166	hsa-miR-151b	CLIP-seq
MIRT2477167	hsa-miR-185	CLIP-seq
MIRT2477168	hsa-miR-2909	CLIP-seq
MIRT2477169	hsa-miR-296-3p	CLIP-seq
MIRT791578	hsa-miR-300	CLIP-seq
MIRT2477170	hsa-miR-301a	CLIP-seq
MIRT2477171	hsa-miR-301b	CLIP-seq
MIRT2477172	hsa-miR-3064-3p	CLIP-seq
MIRT2173579	hsa-miR-3074-3p	CLIP-seq
MIRT2477173	hsa-miR-3123	CLIP-seq
MIRT2477174	hsa-miR-3127-3p	CLIP-seq
MIRT2477175	hsa-miR-3131	CLIP-seq
MIRT2477176	hsa-miR-3162-3p	CLIP-seq
MIRT2477177	hsa-miR-3185	CLIP-seq
MIRT2477178	hsa-miR-3199	CLIP-seq
MIRT2477179	hsa-miR-3605-5p	CLIP-seq
MIRT2477180	hsa-miR-3666	CLIP-seq
MIRT2477181	hsa-miR-380	CLIP-seq
MIRT791581	hsa-miR-381	CLIP-seq
MIRT2477182	hsa-miR-3909	CLIP-seq
MIRT2477183	hsa-miR-3944-5p	CLIP-seq
MIRT2477184	hsa-miR-4267	CLIP-seq
MIRT2477185	hsa-miR-4295	CLIP-seq
MIRT2477186	hsa-miR-4297	CLIP-seq
MIRT2477187	hsa-miR-4306	CLIP-seq
MIRT2477188	hsa-miR-4434	CLIP-seq
MIRT2477189	hsa-miR-4436b-3p	CLIP-seq
MIRT2477190	hsa-miR-4464	CLIP-seq
MIRT2477191	hsa-miR-4471	CLIP-seq
MIRT2477192	hsa-miR-4473	CLIP-seq
MIRT2477193	hsa-miR-4516	CLIP-seq
MIRT2477194	hsa-miR-451b	CLIP-seq
MIRT2477195	hsa-miR-4531	CLIP-seq
MIRT2477196	hsa-miR-454	CLIP-seq
MIRT2477197	hsa-miR-4644	CLIP-seq
MIRT2477198	hsa-miR-4660	CLIP-seq
MIRT791585	hsa-miR-4666-3p	CLIP-seq
MIRT2477199	hsa-miR-4671-3p	CLIP-seq
MIRT2477200	hsa-miR-4709-3p	CLIP-seq
MIRT791586	hsa-miR-4712-5p	CLIP-seq
MIRT2477201	hsa-miR-4722-5p	CLIP-seq
MIRT2477202	hsa-miR-4724-5p	CLIP-seq
MIRT2477203	hsa-miR-4733-5p	CLIP-seq
MIRT2477204	hsa-miR-4748	CLIP-seq
MIRT2477205	hsa-miR-4753-3p	CLIP-seq
MIRT2477206	hsa-miR-4762-3p	CLIP-seq
MIRT2477207	hsa-miR-4768-3p	CLIP-seq
MIRT2477208	hsa-miR-4781-5p	CLIP-seq
MIRT791588	hsa-miR-4789-5p	CLIP-seq
MIRT2477209	hsa-miR-4804-3p	CLIP-seq
MIRT2477210	hsa-miR-485-3p	CLIP-seq
MIRT2477211	hsa-miR-5047	CLIP-seq
MIRT2477212	hsa-miR-510	CLIP-seq
MIRT2477213	hsa-miR-511	CLIP-seq
MIRT2477214	hsa-miR-512-3p	CLIP-seq
MIRT2477215	hsa-miR-512-5p	CLIP-seq
MIRT2477216	hsa-miR-520a-5p	CLIP-seq
MIRT2477217	hsa-miR-520f	CLIP-seq
MIRT2477218	hsa-miR-525-5p	CLIP-seq
MIRT2477219	hsa-miR-550a	CLIP-seq
MIRT2477220	hsa-miR-611	CLIP-seq
MIRT2477221	hsa-miR-620	CLIP-seq
MIRT2477222	hsa-miR-659	CLIP-seq
MIRT2477223	hsa-miR-671-5p	CLIP-seq
MIRT791592	hsa-miR-770-5p	CLIP-seq
MIRT2477160	hsa-miR-1263	CLIP-seq
MIRT2477161	hsa-miR-1270	CLIP-seq
MIRT2675201	hsa-miR-1273d	CLIP-seq
MIRT2477162	hsa-miR-1301	CLIP-seq
MIRT2477163	hsa-miR-130a	CLIP-seq
MIRT2477164	hsa-miR-130b	CLIP-seq
MIRT2477165	hsa-miR-151-5p	CLIP-seq
MIRT2477166	hsa-miR-151b	CLIP-seq
MIRT2477167	hsa-miR-185	CLIP-seq
MIRT2477168	hsa-miR-2909	CLIP-seq
MIRT2477169	hsa-miR-296-3p	CLIP-seq
MIRT791578	hsa-miR-300	CLIP-seq
MIRT2477170	hsa-miR-301a	CLIP-seq
MIRT2477171	hsa-miR-301b	CLIP-seq
MIRT2477172	hsa-miR-3064-3p	CLIP-seq
MIRT2173579	hsa-miR-3074-3p	CLIP-seq
MIRT2477173	hsa-miR-3123	CLIP-seq
MIRT2477174	hsa-miR-3127-3p	CLIP-seq
MIRT2675202	hsa-miR-3127-5p	CLIP-seq
MIRT2477175	hsa-miR-3131	CLIP-seq
MIRT2477176	hsa-miR-3162-3p	CLIP-seq
MIRT2477177	hsa-miR-3185	CLIP-seq
MIRT2477178	hsa-miR-3199	CLIP-seq
MIRT2477179	hsa-miR-3605-5p	CLIP-seq
MIRT2675203	hsa-miR-3646	CLIP-seq
MIRT2477180	hsa-miR-3666	CLIP-seq
MIRT2477181	hsa-miR-380	CLIP-seq
MIRT791581	hsa-miR-381	CLIP-seq
MIRT2477182	hsa-miR-3909	CLIP-seq
MIRT2477183	hsa-miR-3944-5p	CLIP-seq
MIRT2477184	hsa-miR-4267	CLIP-seq
MIRT2675204	hsa-miR-4291	CLIP-seq
MIRT2477185	hsa-miR-4295	CLIP-seq
MIRT2477186	hsa-miR-4297	CLIP-seq
MIRT2477187	hsa-miR-4306	CLIP-seq
MIRT2477188	hsa-miR-4434	CLIP-seq
MIRT2477189	hsa-miR-4436b-3p	CLIP-seq
MIRT2477190	hsa-miR-4464	CLIP-seq
MIRT2477191	hsa-miR-4471	CLIP-seq
MIRT2477192	hsa-miR-4473	CLIP-seq
MIRT2477193	hsa-miR-4516	CLIP-seq
MIRT2477194	hsa-miR-451b	CLIP-seq
MIRT2477195	hsa-miR-4531	CLIP-seq
MIRT2477196	hsa-miR-454	CLIP-seq
MIRT2477197	hsa-miR-4644	CLIP-seq
MIRT2477198	hsa-miR-4660	CLIP-seq
MIRT791585	hsa-miR-4666-3p	CLIP-seq
MIRT2477199	hsa-miR-4671-3p	CLIP-seq
MIRT2675205	hsa-miR-4687-3p	CLIP-seq
MIRT2477200	hsa-miR-4709-3p	CLIP-seq
MIRT791586	hsa-miR-4712-5p	CLIP-seq
MIRT2477201	hsa-miR-4722-5p	CLIP-seq
MIRT2477202	hsa-miR-4724-5p	CLIP-seq
MIRT2477203	hsa-miR-4733-5p	CLIP-seq
MIRT2477204	hsa-miR-4748	CLIP-seq
MIRT2477205	hsa-miR-4753-3p	CLIP-seq
MIRT2477206	hsa-miR-4762-3p	CLIP-seq
MIRT2477207	hsa-miR-4768-3p	CLIP-seq
MIRT2477208	hsa-miR-4781-5p	CLIP-seq
MIRT791588	hsa-miR-4789-5p	CLIP-seq
MIRT2477209	hsa-miR-4804-3p	CLIP-seq
MIRT2477210	hsa-miR-485-3p	CLIP-seq
MIRT2477211	hsa-miR-5047	CLIP-seq
MIRT2477212	hsa-miR-510	CLIP-seq
MIRT2477213	hsa-miR-511	CLIP-seq
MIRT2477214	hsa-miR-512-3p	CLIP-seq
MIRT2477215	hsa-miR-512-5p	CLIP-seq
MIRT2477216	hsa-miR-520a-5p	CLIP-seq
MIRT2477217	hsa-miR-520f	CLIP-seq
MIRT2477218	hsa-miR-525-5p	CLIP-seq
MIRT2675206	hsa-miR-545	CLIP-seq
MIRT2477219	hsa-miR-550a	CLIP-seq
MIRT2477220	hsa-miR-611	CLIP-seq
MIRT2477221	hsa-miR-620	CLIP-seq
MIRT2477222	hsa-miR-659	CLIP-seq
MIRT2477223	hsa-miR-671-5p	CLIP-seq
MIRT791592	hsa-miR-770-5p	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005275	Function	Amine transmembrane transporter activity	TAS	9733774
GO:0005345	Function	Purine nucleobase transmembrane transporter activity	IDA	9733774
GO:0005350	Function	Pyrimidine nucleobase transmembrane transporter activity	IDA	9733774
GO:0005372	Function	Water transmembrane transporter activity	TAS	9733774
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IMP	9514918
GO:0006833	Process	Water transport	IDA	9733774, 30420639
GO:0006833	Process	Water transport	TAS
GO:0006863	Process	Purine nucleobase transport	IDA	9733774
GO:0006970	Process	Response to osmotic stress	TAS	9733774
GO:0007588	Process	Excretion	TAS	9733774
GO:0010033	Process	Response to organic substance	IDA	9733774
GO:0015166	Function	Polyol transmembrane transporter activity	TAS	9733774
GO:0015204	Function	Urea transmembrane transporter activity	IBA	21873635
GO:0015250	Function	Water channel activity	IDA	9733774, 30420639
GO:0015254	Function	Glycerol channel activity	EXP	10564231, 18762715
GO:0015254	Function	Glycerol channel activity	IDA	30420639
GO:0015265	Function	Urea channel activity	IMP	9514918
GO:0015722	Process	Canalicular bile acid transport	IEA
GO:0015791	Process	Polyol transport	IDA	9733774
GO:0015793	Process	Glycerol transport	IDA	30420639
GO:0015793	Process	Glycerol transport	TAS
GO:0015837	Process	Amine transport	IDA	9733774
GO:0015855	Process	Pyrimidine nucleobase transport	IDA	9733774
GO:0016021	Component	Integral component of membrane	NAS	9733774
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030104	Process	Water homeostasis	NAS	9733774
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	18718702
GO:0046689	Process	Response to mercury ion	IDA	9733774
GO:0046942	Process	Carboxylic acid transport	TAS	9733774
GO:0046943	Function	Carboxylic acid transmembrane transporter activity	TAS	9733774
GO:0071320	Process	Cellular response to cAMP	IEP	17636236
GO:0071918	Process	Urea transmembrane transport	IMP	9514918
GO:0072531	Process	Pyrimidine-containing compound transmembrane transport	IEA
GO:1904823	Process	Purine nucleobase transmembrane transport	IEA
GO:1905039	Process	Carboxylic acid transmembrane transport	IEA

MIM	HGNC	e!Ensembl
602914	643	ENSG00000103569

Protein

UniProt ID

O43315

Protein name

Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1)

Protein function

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00230	MIP	17 → 262	Major intrinsic protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen. {ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:9514918}.

Sequence

MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITI
NVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATV
FGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF
DSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAG
NNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM

Sequence length

295

Interactions

View interactions

	KEGG		Reactome
	Neutrophil extracellular trap formation Bile secretion		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Leukemia	leukemia, Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	15336539, 16968895

Show/Hide Text Mining Associations (58)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Rheumatoid	Associate	27026296
Astrocytoma	Associate	29485906
Brain Neoplasms	Associate	18652774, 24086629
Breast Diseases	Associate	33247170
Breast Neoplasms	Associate	33247170, 37681917
Carcinoma Hepatocellular	Associate	27026296, 36212175
Carcinoma Hepatocellular	Inhibit	31969493
Carcinoma Renal Cell	Stimulate	31703694, 35245343
Carcinoma Renal Cell	Associate	36254092
Crohn Disease	Associate	33936061, 36792688, 39475676
Diabetes Gestational	Associate	28942694
Diabetes Gestational	Stimulate	40055514
Diabetes Mellitus	Associate	37773841
Diabetes Mellitus Type 2	Associate	30598999
Drug Related Side Effects and Adverse Reactions	Associate	16968895
Ehlers Danlos syndrome type 3	Associate	27518164
Endocarditis	Associate	20126625, 22319637
Familial Primary Pulmonary Hypertension	Associate	32714978
Glioblastoma	Associate	24086629
Glioma	Associate	24086629, 33637089
Heart Failure	Associate	22319637, 37334672
Huntington Disease	Associate	25626709
Hyperglycemia	Associate	21502813
Hypertension	Associate	32309443
Infections	Associate	20126625
Inflammation	Associate	20126625, 20444268, 27518164, 31703694, 36212175
Intellectual Disability	Associate	27218255
Laryngeal Neoplasms	Inhibit	35477402
Leukemia Myeloid Acute	Associate	25953102
Leukemia Promyelocytic Acute	Associate	16968895
Lung Neoplasms	Associate	24643204
Melanoma	Associate	22130551
Metabolic Diseases	Associate	30598999
Myocardial Infarction	Associate	35231061, 37334672, 37891664
Nasopharyngeal Carcinoma	Stimulate	33564686
Neoplasm Metastasis	Inhibit	31969493
Neoplasms	Associate	18652774, 21819701, 24086629, 33247170
Neoplasms	Stimulate	27187384
Neoplasms	Inhibit	31969493
Obesity	Associate	21502813, 30598999
Ornithine Carbamoyltransferase Deficiency Disease	Associate	34786702
Ovarian Diseases	Associate	21819701
Ovarian Neoplasms	Associate	21819701, 29472315
Overweight	Associate	30598999
Pain	Associate	27518164
Pancreatic Neoplasms	Associate	37761834
Polycystic Ovary Syndrome	Associate	33579525
Prostatic Neoplasms	Associate	27187384
Prostatic Neoplasms	Inhibit	30176851
Pulmonary Disease Chronic Obstructive	Associate	33247170, 36655999
Squamous Cell Carcinoma of Head and Neck	Associate	33466212
Squamous Cell Carcinoma of Head and Neck	Stimulate	36389709
ST Elevation Myocardial Infarction	Associate	38597542
Stomach Diseases	Associate	29678898
Stomach Neoplasms	Associate	29678898, 33247170
Stroke	Associate	32309443
Tang Hsi Ryu syndrome	Stimulate	20126625
Weight Loss	Associate	23475851

AQP9 (aquaporin 9)