Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3638
Gene name Gene Name - the full gene name approved by the HGNC.
Insulin induced gene 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
INSIG1
Synonyms (NCBI Gene) Gene synonyms aliases
CL6
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q36.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018237 hsa-miR-335-5p Microarray 18185580
MIRT024948 hsa-miR-215-5p Microarray 19074876
MIRT026622 hsa-miR-192-5p Microarray 19074876
MIRT026975 hsa-miR-107 Microarray 20489155
MIRT027042 hsa-miR-103a-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 12202038, 15899885, 16168377, 21081644, 21343306, 32296183
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005783 Component Endoplasmic reticulum IDA 12202038, 32322062
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0006641 Process Triglyceride metabolic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602055 6083 ENSG00000186480
Protein
UniProt ID O15503
Protein name Insulin-induced gene 1 protein (INSIG-1)
Protein function Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501,
PDB 4J81
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07281 INSIG 86 267 Insulin-induced protein (INSIG) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues tested with highest expression in the liver. {ECO:0000269|PubMed:12202038}.
Sequence
Sequence length 277
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
26830138
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 12376462
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Schizophrenia Schizophrenia GWAS
Coronary artery disease Coronary artery disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adrenal Hyperplasia Congenital Associate 23570880
Atherosclerosis Associate 35795669
Carcinoma Hepatocellular Associate 25912578
Chromosome 8 deletion Associate 30563842
Colorectal Neoplasms Associate 37087475
Coronary Artery Disease Associate 35795669
Cutis Laxa Autosomal Dominant Associate 21309044
Gout Associate 32630231
HIV Infections Associate 30563842
Hypertriglyceridemia Associate 19965593