INPP1 (inositol polyphosphate-1-phosphatase)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3628
Gene name Inositol polyphosphate-1-phosphatase
Gene symbol INPP1
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2q32.2
Summary This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisp
miRNA miRNA information provided by mirtarbase database.
5
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (5)
miRTarBase ID miRNA Experiments Reference
MIRT1067106 hsa-miR-128 CLIP-seq
MIRT1067107 hsa-miR-27a CLIP-seq
MIRT1067108 hsa-miR-27b CLIP-seq
MIRT1067109 hsa-miR-4328 CLIP-seq
MIRT1067110 hsa-miR-513a-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004441 Function Inositol-1,4-bisphosphate 1-phosphatase activity IBA
GO:0004441 Function Inositol-1,4-bisphosphate 1-phosphatase activity IEA
GO:0004441 Function Inositol-1,4-bisphosphate 1-phosphatase activity ISS
GO:0004441 Function Inositol-1,4-bisphosphate 1-phosphatase activity TAS 8390685
GO:0005515 Function Protein binding IPI 26871637
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147263 6071 ENSG00000151689
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49441
Protein name Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57)
Protein function Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00459 Inositol_P 74 → 381 Inositol monophosphatase family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in pancreas and kidney.
Sequence
Sequence length 399
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system 		  Synthesis of IP2, IP, and Ins in the cytosol
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cleft palate Uncertain significance rs1575788223 RCV000844757
Retinal disorder Uncertain significance rs1575788223 RCV000844757
Show/Hide Text Mining Associations (2)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Cell Transformation Neoplastic Associate 31557403
Uterine Cervical Neoplasms Associate 31557403