Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3608
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin enhancer binding factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ILF2
Synonyms (NCBI Gene) Gene synonyms aliases	NF45, PRO3063
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa

Show/Hide all(224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022452	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT049906	hsa-miR-31-5p	CLASH	23622248
MIRT049279	hsa-miR-92a-3p	CLASH	23622248
MIRT047288	hsa-miR-181b-5p	CLASH	23622248
MIRT046275	hsa-miR-23b-3p	CLASH	23622248
MIRT045674	hsa-miR-149-5p	CLASH	23622248
MIRT043419	hsa-miR-331-3p	CLASH	23622248
MIRT042209	hsa-miR-484	CLASH	23622248
MIRT040442	hsa-miR-615-3p	CLASH	23622248
MIRT036602	hsa-miR-940	CLASH	23622248
MIRT1065429	hsa-miR-1	CLIP-seq
MIRT1065430	hsa-miR-1270	CLIP-seq
MIRT1065431	hsa-miR-1305	CLIP-seq
MIRT1065432	hsa-miR-1323	CLIP-seq
MIRT1065433	hsa-miR-206	CLIP-seq
MIRT1065434	hsa-miR-3120-3p	CLIP-seq
MIRT1065435	hsa-miR-3130-5p	CLIP-seq
MIRT1065436	hsa-miR-3143	CLIP-seq
MIRT1065437	hsa-miR-3180-5p	CLIP-seq
MIRT1065438	hsa-miR-3673	CLIP-seq
MIRT1065439	hsa-miR-3973	CLIP-seq
MIRT1065440	hsa-miR-421	CLIP-seq
MIRT1065441	hsa-miR-425	CLIP-seq
MIRT1065442	hsa-miR-4282	CLIP-seq
MIRT1065443	hsa-miR-4433	CLIP-seq
MIRT1065444	hsa-miR-4459	CLIP-seq
MIRT1065445	hsa-miR-4482	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT1065447	hsa-miR-4514	CLIP-seq
MIRT1065448	hsa-miR-4531	CLIP-seq
MIRT1065449	hsa-miR-4683	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT1065451	hsa-miR-4692	CLIP-seq
MIRT1065452	hsa-miR-4709-5p	CLIP-seq
MIRT1065453	hsa-miR-4768-3p	CLIP-seq
MIRT1065454	hsa-miR-513a-3p	CLIP-seq
MIRT1065455	hsa-miR-513b	CLIP-seq
MIRT1065456	hsa-miR-520a-5p	CLIP-seq
MIRT1065457	hsa-miR-525-5p	CLIP-seq
MIRT1065458	hsa-miR-543	CLIP-seq
MIRT1065459	hsa-miR-545	CLIP-seq
MIRT1065460	hsa-miR-548l	CLIP-seq
MIRT1065461	hsa-miR-548o	CLIP-seq
MIRT1065462	hsa-miR-571	CLIP-seq
MIRT1065463	hsa-miR-613	CLIP-seq
MIRT1065464	hsa-miR-620	CLIP-seq
MIRT1065465	hsa-miR-654-3p	CLIP-seq
MIRT1065466	hsa-miR-662	CLIP-seq
MIRT1065467	hsa-miR-885-3p	CLIP-seq
MIRT1065429	hsa-miR-1	CLIP-seq
MIRT2015568	hsa-miR-1193	CLIP-seq
MIRT2015569	hsa-miR-1225-5p	CLIP-seq
MIRT1065430	hsa-miR-1270	CLIP-seq
MIRT1065431	hsa-miR-1305	CLIP-seq
MIRT2015570	hsa-miR-136	CLIP-seq
MIRT1065433	hsa-miR-206	CLIP-seq
MIRT2015571	hsa-miR-3074-5p	CLIP-seq
MIRT2015572	hsa-miR-3117-5p	CLIP-seq
MIRT1065434	hsa-miR-3120-3p	CLIP-seq
MIRT2015573	hsa-miR-3132	CLIP-seq
MIRT2015574	hsa-miR-3134	CLIP-seq
MIRT1065436	hsa-miR-3143	CLIP-seq
MIRT2015575	hsa-miR-3179	CLIP-seq
MIRT1065437	hsa-miR-3180-5p	CLIP-seq
MIRT2015576	hsa-miR-3189-3p	CLIP-seq
MIRT1065438	hsa-miR-3673	CLIP-seq
MIRT2015577	hsa-miR-3679-3p	CLIP-seq
MIRT2015578	hsa-miR-370	CLIP-seq
MIRT2015579	hsa-miR-3925-3p	CLIP-seq
MIRT1065439	hsa-miR-3973	CLIP-seq
MIRT2015580	hsa-miR-409-3p	CLIP-seq
MIRT1065440	hsa-miR-421	CLIP-seq
MIRT1065441	hsa-miR-425	CLIP-seq
MIRT1065443	hsa-miR-4433	CLIP-seq
MIRT1065444	hsa-miR-4459	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT2015581	hsa-miR-4496	CLIP-seq
MIRT1065447	hsa-miR-4514	CLIP-seq
MIRT2015582	hsa-miR-4528	CLIP-seq
MIRT1065448	hsa-miR-4531	CLIP-seq
MIRT2015583	hsa-miR-4653-3p	CLIP-seq
MIRT2015584	hsa-miR-4659a-3p	CLIP-seq
MIRT2015585	hsa-miR-4659b-3p	CLIP-seq
MIRT1065449	hsa-miR-4683	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT2015586	hsa-miR-4691-5p	CLIP-seq
MIRT1065451	hsa-miR-4692	CLIP-seq
MIRT1065452	hsa-miR-4709-5p	CLIP-seq
MIRT2015587	hsa-miR-4733-5p	CLIP-seq
MIRT1065453	hsa-miR-4768-3p	CLIP-seq
MIRT2015588	hsa-miR-4781-3p	CLIP-seq
MIRT2015589	hsa-miR-4802-5p	CLIP-seq
MIRT1065455	hsa-miR-513b	CLIP-seq
MIRT1065456	hsa-miR-520a-5p	CLIP-seq
MIRT1065457	hsa-miR-525-5p	CLIP-seq
MIRT1065458	hsa-miR-543	CLIP-seq
MIRT1065459	hsa-miR-545	CLIP-seq
MIRT1065460	hsa-miR-548l	CLIP-seq
MIRT1065462	hsa-miR-571	CLIP-seq
MIRT1065463	hsa-miR-613	CLIP-seq
MIRT1065464	hsa-miR-620	CLIP-seq
MIRT1065465	hsa-miR-654-3p	CLIP-seq
MIRT1065466	hsa-miR-662	CLIP-seq
MIRT1065467	hsa-miR-885-3p	CLIP-seq
MIRT2015590	hsa-miR-885-5p	CLIP-seq
MIRT1065429	hsa-miR-1	CLIP-seq
MIRT2015568	hsa-miR-1193	CLIP-seq
MIRT1065430	hsa-miR-1270	CLIP-seq
MIRT1065431	hsa-miR-1305	CLIP-seq
MIRT1065432	hsa-miR-1323	CLIP-seq
MIRT2015570	hsa-miR-136	CLIP-seq
MIRT1065433	hsa-miR-206	CLIP-seq
MIRT2015571	hsa-miR-3074-5p	CLIP-seq
MIRT2015572	hsa-miR-3117-5p	CLIP-seq
MIRT1065434	hsa-miR-3120-3p	CLIP-seq
MIRT1065435	hsa-miR-3130-5p	CLIP-seq
MIRT2015574	hsa-miR-3134	CLIP-seq
MIRT1065436	hsa-miR-3143	CLIP-seq
MIRT1065437	hsa-miR-3180-5p	CLIP-seq
MIRT1065438	hsa-miR-3673	CLIP-seq
MIRT2015578	hsa-miR-370	CLIP-seq
MIRT2015579	hsa-miR-3925-3p	CLIP-seq
MIRT1065439	hsa-miR-3973	CLIP-seq
MIRT1065440	hsa-miR-421	CLIP-seq
MIRT1065441	hsa-miR-425	CLIP-seq
MIRT1065443	hsa-miR-4433	CLIP-seq
MIRT1065444	hsa-miR-4459	CLIP-seq
MIRT2247879	hsa-miR-4463	CLIP-seq
MIRT1065445	hsa-miR-4482	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT1065447	hsa-miR-4514	CLIP-seq
MIRT2015582	hsa-miR-4528	CLIP-seq
MIRT1065448	hsa-miR-4531	CLIP-seq
MIRT2015583	hsa-miR-4653-3p	CLIP-seq
MIRT2015584	hsa-miR-4659a-3p	CLIP-seq
MIRT2015585	hsa-miR-4659b-3p	CLIP-seq
MIRT1065449	hsa-miR-4683	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT2015586	hsa-miR-4691-5p	CLIP-seq
MIRT1065451	hsa-miR-4692	CLIP-seq
MIRT1065452	hsa-miR-4709-5p	CLIP-seq
MIRT2247880	hsa-miR-4719	CLIP-seq
MIRT2015587	hsa-miR-4733-5p	CLIP-seq
MIRT1065453	hsa-miR-4768-3p	CLIP-seq
MIRT2015589	hsa-miR-4802-5p	CLIP-seq
MIRT1065455	hsa-miR-513b	CLIP-seq
MIRT1065456	hsa-miR-520a-5p	CLIP-seq
MIRT1065457	hsa-miR-525-5p	CLIP-seq
MIRT1065458	hsa-miR-543	CLIP-seq
MIRT1065459	hsa-miR-545	CLIP-seq
MIRT1065460	hsa-miR-548l	CLIP-seq
MIRT1065461	hsa-miR-548o	CLIP-seq
MIRT1065462	hsa-miR-571	CLIP-seq
MIRT1065463	hsa-miR-613	CLIP-seq
MIRT1065464	hsa-miR-620	CLIP-seq
MIRT1065467	hsa-miR-885-3p	CLIP-seq
MIRT2015590	hsa-miR-885-5p	CLIP-seq
MIRT1065443	hsa-miR-4433	CLIP-seq
MIRT1065444	hsa-miR-4459	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT1065453	hsa-miR-4768-3p	CLIP-seq
MIRT1065429	hsa-miR-1	CLIP-seq
MIRT2015569	hsa-miR-1225-5p	CLIP-seq
MIRT1065432	hsa-miR-1323	CLIP-seq
MIRT1065433	hsa-miR-206	CLIP-seq
MIRT2015571	hsa-miR-3074-5p	CLIP-seq
MIRT2015572	hsa-miR-3117-5p	CLIP-seq
MIRT1065435	hsa-miR-3130-5p	CLIP-seq
MIRT2015573	hsa-miR-3132	CLIP-seq
MIRT2015575	hsa-miR-3179	CLIP-seq
MIRT2015576	hsa-miR-3189-3p	CLIP-seq
MIRT1065438	hsa-miR-3673	CLIP-seq
MIRT2015577	hsa-miR-3679-3p	CLIP-seq
MIRT2015578	hsa-miR-370	CLIP-seq
MIRT2015579	hsa-miR-3925-3p	CLIP-seq
MIRT1065441	hsa-miR-425	CLIP-seq
MIRT1065445	hsa-miR-4482	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT2015581	hsa-miR-4496	CLIP-seq
MIRT1065447	hsa-miR-4514	CLIP-seq
MIRT2015583	hsa-miR-4653-3p	CLIP-seq
MIRT2015584	hsa-miR-4659a-3p	CLIP-seq
MIRT2015585	hsa-miR-4659b-3p	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT1065451	hsa-miR-4692	CLIP-seq
MIRT2015587	hsa-miR-4733-5p	CLIP-seq
MIRT2015589	hsa-miR-4802-5p	CLIP-seq
MIRT1065461	hsa-miR-548o	CLIP-seq
MIRT1065463	hsa-miR-613	CLIP-seq
MIRT1065465	hsa-miR-654-3p	CLIP-seq
MIRT1065466	hsa-miR-662	CLIP-seq
MIRT1065467	hsa-miR-885-3p	CLIP-seq
MIRT1065429	hsa-miR-1	CLIP-seq
MIRT2015569	hsa-miR-1225-5p	CLIP-seq
MIRT1065432	hsa-miR-1323	CLIP-seq
MIRT1065433	hsa-miR-206	CLIP-seq
MIRT2015571	hsa-miR-3074-5p	CLIP-seq
MIRT2015572	hsa-miR-3117-5p	CLIP-seq
MIRT1065435	hsa-miR-3130-5p	CLIP-seq
MIRT2015573	hsa-miR-3132	CLIP-seq
MIRT2015575	hsa-miR-3179	CLIP-seq
MIRT2015576	hsa-miR-3189-3p	CLIP-seq
MIRT1065438	hsa-miR-3673	CLIP-seq
MIRT2015577	hsa-miR-3679-3p	CLIP-seq
MIRT2015578	hsa-miR-370	CLIP-seq
MIRT2015579	hsa-miR-3925-3p	CLIP-seq
MIRT1065441	hsa-miR-425	CLIP-seq
MIRT1065445	hsa-miR-4482	CLIP-seq
MIRT1065446	hsa-miR-4495	CLIP-seq
MIRT2015581	hsa-miR-4496	CLIP-seq
MIRT1065447	hsa-miR-4514	CLIP-seq
MIRT2015583	hsa-miR-4653-3p	CLIP-seq
MIRT2015584	hsa-miR-4659a-3p	CLIP-seq
MIRT2015585	hsa-miR-4659b-3p	CLIP-seq
MIRT1065450	hsa-miR-4690-5p	CLIP-seq
MIRT1065451	hsa-miR-4692	CLIP-seq
MIRT2015587	hsa-miR-4733-5p	CLIP-seq
MIRT2015589	hsa-miR-4802-5p	CLIP-seq
MIRT1065461	hsa-miR-548o	CLIP-seq
MIRT1065463	hsa-miR-613	CLIP-seq
MIRT1065465	hsa-miR-654-3p	CLIP-seq
MIRT1065466	hsa-miR-662	CLIP-seq
MIRT1065467	hsa-miR-885-3p	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IDA	7519613, 10574923, 11804788
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003725	Function	Double-stranded RNA binding	IDA	10574923
GO:0005515	Function	Protein binding	IPI	9442054, 10574923, 11739746, 17289661, 21146485, 32296183
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	21123651
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA	11790298
GO:0016020	Component	Membrane	HDA	19946888
GO:0035580	Component	Specific granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	11739746
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

MIM	HGNC	e!Ensembl
603181	6037	ENSG00000143621

Protein

UniProt ID

Q12905

Protein name

Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)

Protein function

Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07528	DZF	104 → 338	DZF domain	Domain

Sequence

MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKR
NQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVA
DLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTV
PPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPL
TPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHT
VMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEK
PPEKKEGEEEEENTEEPPQGEEEESMETQE

Sequence length

390

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059 View all (2 more)	28191889

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	37047232
Adenocarcinoma of Lung	Associate	33535033
Blind Loop Syndrome	Associate	37047232
Breast Neoplasms	Associate	37298108
Carcinogenesis	Associate	25023405, 25286760
Carcinoma Hepatocellular	Associate	27519414, 30881868
Cholangiocarcinoma	Associate	32116234
Colorectal Neoplasms	Associate	23799036
DNA Virus Infections	Associate	37047232
Dysgerminoma	Stimulate	21793190
Encephalitis Japanese	Inhibit	31212927
Endodermal Sinus Tumor	Stimulate	21793190
Esophageal Squamous Cell Carcinoma	Associate	25286760, 36717549
Glioma	Associate	25023405
Glycogen Storage Disease IIIB	Associate	34709752
HIV Infections	Stimulate	26891316
Inflammation	Associate	32388272
Lymphatic Metastasis	Stimulate	28831206
Melanoma	Associate	34709752
Multiple Myeloma	Associate	28669490, 35145187
Neoplasms	Associate	23799036, 25023405, 25286760, 37864310
Neoplasms Germ Cell and Embryonal	Associate	21793190
Pancreatic Neoplasms	Stimulate	28259961
Prostatic Neoplasms	Associate	37047232
Squamous Cell Carcinoma of Head and Neck	Associate	35333683, 37864310
Stomach Neoplasms	Associate	28831206
Triple Negative Breast Neoplasms	Associate	38238853
Uterine Cervical Neoplasms	Associate	23208500, 39968981

ILF2 (interleukin enhancer binding factor 2)