CXCR1 (C-X-C motif chemokine receptor 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3577
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCR1
Synonyms (NCBI Gene) Gene synonyms aliases
C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q35
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system.
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(60)
miRTarBase ID miRNA Experiments Reference
MIRT017488 hsa-miR-335-5p Microarray 18185580
MIRT029277 hsa-miR-26b-5p Microarray 19088304
MIRT918149 hsa-miR-141 CLIP-seq
MIRT918150 hsa-miR-200a CLIP-seq
MIRT918151 hsa-miR-2110 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
SPI1 Activation 9867862
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(32)
GO ID Ontology Definition Evidence Reference
GO:0002407 Process Dendritic cell chemotaxis IEA
GO:0002407 Process Dendritic cell chemotaxis TAS 16621978
GO:0004918 Function Interleukin-8 receptor activity IDA 10734056
GO:0004918 Function Interleukin-8 receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
146929 6026 ENSG00000163464
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P25024
Protein name C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
Protein function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-cal
PDB 1ILP , 1ILQ , 2LNL , 6XMN , 8IC0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 56 → 305 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Phospholipase D signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Hypertension Idiopathic intracranial hypertension N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Show/Hide Text Mining Associations (123)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abscess Associate 12002274
Acquired Immunodeficiency Syndrome Associate 17360650
Acute On Chronic Liver Failure Inhibit 27974825
Adenocarcinoma Follicular Associate 26617848
Adenocarcinoma Mucinous Associate 27533245
Adenocarcinoma of Lung Inhibit 35768814
Adenocarcinoma of Lung Associate 37770496
Adenoma Stimulate 26617848
Adenomyosis Associate 16500343
Arthritis Rheumatoid Associate 12932287, 24914212, 25853812