LRRTM3 (leucine rich repeat transmembrane neuronal 3)

Gene

• Entrez ID: 347731
• Gene name: Leucine rich repeat transmembrane neuronal 3
• Gene symbol: LRRTM3
• Synonyms (NCBI Gene): -
• Chromosome: 10
• Chromosome location: 10q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1121097	hsa-miR-1265	CLIP-seq
MIRT1121098	hsa-miR-1298	CLIP-seq
MIRT1121099	hsa-miR-186	CLIP-seq
MIRT1121100	hsa-miR-3163	CLIP-seq
MIRT1121101	hsa-miR-3622b-5p	CLIP-seq
MIRT1121102	hsa-miR-371b-5p	CLIP-seq
MIRT1121103	hsa-miR-3978	CLIP-seq
MIRT1121104	hsa-miR-4477a	CLIP-seq
MIRT1121105	hsa-miR-4477b	CLIP-seq
MIRT1121106	hsa-miR-548u	CLIP-seq
MIRT1121107	hsa-miR-664	CLIP-seq
MIRT1121108	hsa-miR-888	CLIP-seq
MIRT1121098	hsa-miR-1298	CLIP-seq
MIRT2034272	hsa-miR-203	CLIP-seq
MIRT2034273	hsa-miR-3121-5p	CLIP-seq
MIRT2034274	hsa-miR-3607-3p	CLIP-seq
MIRT2034275	hsa-miR-4307	CLIP-seq
MIRT2034276	hsa-miR-4760-3p	CLIP-seq
MIRT2034277	hsa-miR-4778-3p	CLIP-seq
MIRT2034278	hsa-miR-513a-3p	CLIP-seq
MIRT1121106	hsa-miR-548u	CLIP-seq
MIRT2034279	hsa-miR-580	CLIP-seq
MIRT1121097	hsa-miR-1265	CLIP-seq
MIRT2264730	hsa-miR-128	CLIP-seq
MIRT2264731	hsa-miR-1291	CLIP-seq
MIRT2264732	hsa-miR-146b-3p	CLIP-seq
MIRT2264733	hsa-miR-2052	CLIP-seq
MIRT2264734	hsa-miR-27a	CLIP-seq
MIRT2264735	hsa-miR-27b	CLIP-seq
MIRT2264736	hsa-miR-3168	CLIP-seq
MIRT2264737	hsa-miR-3170	CLIP-seq
MIRT2264738	hsa-miR-328	CLIP-seq
MIRT2264739	hsa-miR-342-3p	CLIP-seq
MIRT2264740	hsa-miR-4260	CLIP-seq
MIRT2264741	hsa-miR-4277	CLIP-seq
MIRT1121104	hsa-miR-4477a	CLIP-seq
MIRT1121105	hsa-miR-4477b	CLIP-seq
MIRT2034276	hsa-miR-4760-3p	CLIP-seq
MIRT2264742	hsa-miR-4799-5p	CLIP-seq
MIRT2034275	hsa-miR-4307	CLIP-seq
MIRT2453425	hsa-miR-3154	CLIP-seq
MIRT2453426	hsa-miR-3173-3p	CLIP-seq
MIRT2453427	hsa-miR-433	CLIP-seq
MIRT2034277	hsa-miR-4778-3p	CLIP-seq
MIRT2684229	hsa-miR-3653	CLIP-seq
MIRT2684230	hsa-miR-3658	CLIP-seq
MIRT2684231	hsa-miR-382	CLIP-seq
MIRT2264742	hsa-miR-4799-5p	CLIP-seq
MIRT2684232	hsa-miR-511	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	26776509
GO:0098978	Component	Glutamatergic synapse	IMP	26776509
GO:0099054	Process	Presynapse assembly	IDA	26776509
GO:0099054	Process	Presynapse assembly	IMP	26776509
GO:0099061	Component	Integral component of postsynaptic density membrane	IEA
GO:1902004	Process	Positive regulation of amyloid-beta formation	IMP	17098871

Other IDs

• MIM: 610869
• HGNC: 19410
• e!Ensembl: ENSG00000198739

Protein

• UniProt ID: Q86VH5
• Protein name: Leucine-rich repeat transmembrane neuronal protein 3
• Protein function: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	87 → 145	Leucine rich repeat	Repeat
  PF13855	LRR_8	133 → 193	Leucine rich repeat	Repeat
  PF13855	LRR_8	157 → 217	Leucine rich repeat	Repeat
  PF13855	LRR_8	181 → 241	Leucine rich repeat	Repeat
  PF13855	LRR_8	229 → 290	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in neuronal tissues. {ECO:0000269|PubMed:12676565}.
• Sequence:

  MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS
  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR
  ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC
  RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK
  ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS
  WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI
  CGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKI
  IAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFY
  VDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELL
  SHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA

• Sequence length: 581

Pathways

Reactome:

Neurexins and neuroligins

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	20678249
Tremor	Essential Tremor	rs387907274, rs763485258, rs551348450	27797806

Unknown
Disease term	Disease name	Evidence	References	Source
Ulcerative colitis	Ulcerative colitis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	18076107, 19105203, 22393166