LRRTM3 (leucine rich repeat transmembrane neuronal 3)

Gene

• Entrez ID: 347731
• Gene name: Leucine rich repeat transmembrane neuronal 3
• Gene symbol: LRRTM3
• Synonyms (NCBI Gene): -
• Chromosome: 10
• Chromosome location: 10q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1121097	hsa-miR-1265	CLIP-seq
MIRT1121098	hsa-miR-1298	CLIP-seq
MIRT1121099	hsa-miR-186	CLIP-seq
MIRT1121100	hsa-miR-3163	CLIP-seq
MIRT1121101	hsa-miR-3622b-5p	CLIP-seq
MIRT1121102	hsa-miR-371b-5p	CLIP-seq
MIRT1121103	hsa-miR-3978	CLIP-seq
MIRT1121104	hsa-miR-4477a	CLIP-seq
MIRT1121105	hsa-miR-4477b	CLIP-seq
MIRT1121106	hsa-miR-548u	CLIP-seq
MIRT1121107	hsa-miR-664	CLIP-seq
MIRT1121108	hsa-miR-888	CLIP-seq
MIRT1121098	hsa-miR-1298	CLIP-seq
MIRT2034272	hsa-miR-203	CLIP-seq
MIRT2034273	hsa-miR-3121-5p	CLIP-seq
MIRT2034274	hsa-miR-3607-3p	CLIP-seq
MIRT2034275	hsa-miR-4307	CLIP-seq
MIRT2034276	hsa-miR-4760-3p	CLIP-seq
MIRT2034277	hsa-miR-4778-3p	CLIP-seq
MIRT2034278	hsa-miR-513a-3p	CLIP-seq
MIRT1121106	hsa-miR-548u	CLIP-seq
MIRT2034279	hsa-miR-580	CLIP-seq
MIRT1121097	hsa-miR-1265	CLIP-seq
MIRT2264730	hsa-miR-128	CLIP-seq
MIRT2264731	hsa-miR-1291	CLIP-seq
MIRT2264732	hsa-miR-146b-3p	CLIP-seq
MIRT2264733	hsa-miR-2052	CLIP-seq
MIRT2264734	hsa-miR-27a	CLIP-seq
MIRT2264735	hsa-miR-27b	CLIP-seq
MIRT2264736	hsa-miR-3168	CLIP-seq
MIRT2264737	hsa-miR-3170	CLIP-seq
MIRT2264738	hsa-miR-328	CLIP-seq
MIRT2264739	hsa-miR-342-3p	CLIP-seq
MIRT2264740	hsa-miR-4260	CLIP-seq
MIRT2264741	hsa-miR-4277	CLIP-seq
MIRT1121104	hsa-miR-4477a	CLIP-seq
MIRT1121105	hsa-miR-4477b	CLIP-seq
MIRT2034276	hsa-miR-4760-3p	CLIP-seq
MIRT2264742	hsa-miR-4799-5p	CLIP-seq
MIRT2034275	hsa-miR-4307	CLIP-seq
MIRT2453425	hsa-miR-3154	CLIP-seq
MIRT2453426	hsa-miR-3173-3p	CLIP-seq
MIRT2453427	hsa-miR-433	CLIP-seq
MIRT2034277	hsa-miR-4778-3p	CLIP-seq
MIRT2684229	hsa-miR-3653	CLIP-seq
MIRT2684230	hsa-miR-3658	CLIP-seq
MIRT2684231	hsa-miR-382	CLIP-seq
MIRT2264742	hsa-miR-4799-5p	CLIP-seq
MIRT2684232	hsa-miR-511	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	26776509
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IMP	26776509
GO:1902004	Process	Positive regulation of amyloid-beta formation	IEA
GO:1902004	Process	Positive regulation of amyloid-beta formation	IMP	17098871
GO:1905606	Process	Regulation of presynapse assembly	IDA	26776509
GO:1905606	Process	Regulation of presynapse assembly	IMP	26776509

Other IDs

• MIM: 610869
• HGNC: 19410
• e!Ensembl: ENSG00000198739

Protein

• UniProt ID: Q86VH5
• Protein name: Leucine-rich repeat transmembrane neuronal protein 3
• Protein function: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	87 → 145	Leucine rich repeat	Repeat
  PF13855	LRR_8	133 → 193	Leucine rich repeat	Repeat
  PF13855	LRR_8	157 → 217	Leucine rich repeat	Repeat
  PF13855	LRR_8	181 → 241	Leucine rich repeat	Repeat
  PF13855	LRR_8	229 → 290	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in neuronal tissues. {ECO:0000269|PubMed:12676565}.
• Sequence:

  MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSIS
  AGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNR
  ISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDC
  RNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK
  ISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS
  WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSI
  CGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKI
  IAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFY
  VDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELL
  SHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA

• Sequence length: 581

Pathways

Reactome:

Neurexins and neuroligins

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Tremor	Essential tremor	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	18076107, 19105203, 22393166