APOD (apolipoprotein D)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
347
Gene name Gene Name - the full gene name approved by the HGNC.
Apolipoprotein D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
APOD
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamil
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT790044 hsa-miR-214 CLIP-seq
MIRT790045 hsa-miR-3619-5p CLIP-seq
MIRT790046 hsa-miR-3622b-5p CLIP-seq
MIRT790047 hsa-miR-409-5p CLIP-seq
MIRT790048 hsa-miR-4253 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
NOTCH3 Repression 21705670
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000302 Process Response to reactive oxygen species IBA
GO:0000302 Process Response to reactive oxygen species IDA 18419796
GO:0000302 Process Response to reactive oxygen species IEA
GO:0001525 Process Angiogenesis NAS 21705670
GO:0005319 Function Lipid transporter activity NAS 3453108
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
107740 612 ENSG00000189058
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05090
Protein name Apolipoprotein D (Apo-D) (ApoD)
Protein function APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
PDB 2HZQ , 2HZR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 43 → 184 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.
Sequence
Sequence length 189
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Transport of fatty acids
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Show/Hide Text Mining Associations (60)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Stimulate 30467822, 9751198
Alzheimer Disease Associate 37264161
Androgen Insensitivity Syndrome Associate 19330472, 27583472
Bipolar Disorder Stimulate 11274430
Brain Damage Chronic Associate 25261976
Breast Neoplasms Associate 11167212, 33550915, 34224831, 36243728, 7929425, 8311115, 8883401, 8943263
Carcinoma Hepatocellular Associate 17589901
Carcinoma Squamous Cell Associate 33671013
Carotid Stenosis Associate 30335165
Cerebral Infarction Associate 25261976