Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3434
Gene name	Interferon induced protein with tetratricopeptide repeats 1
Gene symbol	IFIT1
Synonyms (NCBI Gene)	C56G10P1IFI-56IFI-56KIFI56IFIT-1IFNAI1ISG56P56RNM561
Chromosome	10
Chromosome location	10q23.31
Summary	This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020013	hsa-miR-375	Microarray	20215506
MIRT021232	hsa-miR-146a-5p	Microarray	18057241
MIRT024022	hsa-miR-1-3p	Microarray	18668037
MIRT437408	hsa-miR-203a-3p	Next Generation Sequencing (NGS)qRT-PCRWestern blot	23785202
MIRT709996	hsa-miR-126-5p	HITS-CLIP	19536157
MIRT709995	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT709994	hsa-miR-1248	HITS-CLIP	19536157
MIRT709992	hsa-miR-4795-3p	HITS-CLIP	19536157
MIRT709993	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT445799	hsa-miR-380-3p	PAR-CLIP	22100165
MIRT445797	hsa-miR-6516-3p	PAR-CLIP	22100165
MIRT445796	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445795	hsa-miR-2054	PAR-CLIP	22100165
MIRT445794	hsa-miR-578	PAR-CLIP	22100165
MIRT445793	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT445799	hsa-miR-380-3p	PAR-CLIP	22100165
MIRT445798	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT445797	hsa-miR-6516-3p	PAR-CLIP	22100165
MIRT445796	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445795	hsa-miR-2054	PAR-CLIP	22100165
MIRT445794	hsa-miR-578	PAR-CLIP	22100165
MIRT445793	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT737067	hsa-miR-4756-5p	Luciferase reporter assayWestern blottingqRT-PCR	33707417
MIRT709996	hsa-miR-126-5p	HITS-CLIP	19536157
MIRT709995	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT709994	hsa-miR-1248	HITS-CLIP	19536157
MIRT709992	hsa-miR-4795-3p	HITS-CLIP	19536157
MIRT709993	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT445799	hsa-miR-380-3p	PAR-CLIP	22100165
MIRT445797	hsa-miR-6516-3p	PAR-CLIP	22100165
MIRT445796	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445795	hsa-miR-2054	PAR-CLIP	22100165
MIRT445794	hsa-miR-578	PAR-CLIP	22100165
MIRT445793	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT445799	hsa-miR-380-3p	PAR-CLIP	22100165
MIRT445798	hsa-miR-1250-3p	PAR-CLIP	22100165
MIRT445797	hsa-miR-6516-3p	PAR-CLIP	22100165
MIRT445796	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445795	hsa-miR-2054	PAR-CLIP	22100165
MIRT445794	hsa-miR-578	PAR-CLIP	22100165
MIRT445793	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT2246315	hsa-miR-329	CLIP-seq
MIRT2246316	hsa-miR-362-3p	CLIP-seq
MIRT2246317	hsa-miR-3941	CLIP-seq
MIRT2246318	hsa-miR-4272	CLIP-seq
MIRT2246319	hsa-miR-4666-5p	CLIP-seq
MIRT2246320	hsa-miR-600	CLIP-seq
MIRT2246321	hsa-miR-603	CLIP-seq
MIRT2549561	hsa-miR-3129-3p	CLIP-seq
MIRT2549562	hsa-miR-3143	CLIP-seq
MIRT2246315	hsa-miR-329	CLIP-seq
MIRT2246316	hsa-miR-362-3p	CLIP-seq
MIRT2549563	hsa-miR-374a	CLIP-seq
MIRT2549564	hsa-miR-374b	CLIP-seq
MIRT2549565	hsa-miR-376c	CLIP-seq
MIRT2246317	hsa-miR-3941	CLIP-seq
MIRT2549566	hsa-miR-409-3p	CLIP-seq
MIRT2246318	hsa-miR-4272	CLIP-seq
MIRT2549567	hsa-miR-4652-3p	CLIP-seq
MIRT2246319	hsa-miR-4666-5p	CLIP-seq
MIRT2549568	hsa-miR-4684-5p	CLIP-seq
MIRT2549569	hsa-miR-4753-3p	CLIP-seq
MIRT2549570	hsa-miR-4762-3p	CLIP-seq
MIRT2549571	hsa-miR-4766-5p	CLIP-seq
MIRT2549572	hsa-miR-4768-5p	CLIP-seq
MIRT2549573	hsa-miR-4778-5p	CLIP-seq
MIRT2549574	hsa-miR-485-3p	CLIP-seq
MIRT2549575	hsa-miR-499-3p	CLIP-seq
MIRT2549576	hsa-miR-499a-3p	CLIP-seq
MIRT2549577	hsa-miR-543	CLIP-seq
MIRT2549578	hsa-miR-570	CLIP-seq
MIRT2549579	hsa-miR-582-5p	CLIP-seq
MIRT2246320	hsa-miR-600	CLIP-seq
MIRT2246321	hsa-miR-603	CLIP-seq
MIRT2549580	hsa-miR-653	CLIP-seq
MIRT2549561	hsa-miR-3129-3p	CLIP-seq
MIRT2549562	hsa-miR-3143	CLIP-seq
MIRT2246315	hsa-miR-329	CLIP-seq
MIRT2246316	hsa-miR-362-3p	CLIP-seq
MIRT2549563	hsa-miR-374a	CLIP-seq
MIRT2549564	hsa-miR-374b	CLIP-seq
MIRT2549565	hsa-miR-376c	CLIP-seq
MIRT2246317	hsa-miR-3941	CLIP-seq
MIRT2549566	hsa-miR-409-3p	CLIP-seq
MIRT2246318	hsa-miR-4272	CLIP-seq
MIRT2549567	hsa-miR-4652-3p	CLIP-seq
MIRT2246319	hsa-miR-4666-5p	CLIP-seq
MIRT2549568	hsa-miR-4684-5p	CLIP-seq
MIRT2549569	hsa-miR-4753-3p	CLIP-seq
MIRT2549570	hsa-miR-4762-3p	CLIP-seq
MIRT2549571	hsa-miR-4766-5p	CLIP-seq
MIRT2549572	hsa-miR-4768-5p	CLIP-seq
MIRT2549573	hsa-miR-4778-5p	CLIP-seq
MIRT2549574	hsa-miR-485-3p	CLIP-seq
MIRT2549575	hsa-miR-499-3p	CLIP-seq
MIRT2549576	hsa-miR-499a-3p	CLIP-seq
MIRT2549577	hsa-miR-543	CLIP-seq
MIRT2549578	hsa-miR-570	CLIP-seq
MIRT2549579	hsa-miR-582-5p	CLIP-seq
MIRT2246320	hsa-miR-600	CLIP-seq
MIRT2246321	hsa-miR-603	CLIP-seq
MIRT2549580	hsa-miR-653	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	21642987
GO:0003723	Function	RNA binding	IEA
GO:0004857	Function	Enzyme inhibitor activity	IDA	19008854
GO:0005515	Function	Protein binding	IPI	16189514, 19008854, 19416887, 21190939, 21612406, 21642987, 25416956, 27107012, 28514442, 30833792, 31515488, 33961781
GO:0005737	Component	Cytoplasm	IDA	19008854, 21642987
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0009615	Process	Response to virus	IDA	19416887
GO:0009615	Process	Response to virus	IMP	21642987
GO:0019060	Process	Intracellular transport of viral protein in host cell	IDA	19008854
GO:0043657	Component	Host cell	IEA
GO:0045070	Process	Positive regulation of viral genome replication	IDA	19416887
GO:0045071	Process	Negative regulation of viral genome replication	IMP	19008854, 21976647
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0051707	Process	Response to other organism	IEA
GO:0071357	Process	Cellular response to type I interferon	IDA	19008854
GO:0071360	Process	Cellular response to exogenous dsRNA	IDA	19008854
GO:0140374	Process	Antiviral innate immune response	IDA	19008854
GO:0140374	Process	Antiviral innate immune response	IEP	25930096
GO:0140610	Function	RNA sequestering activity	IDA	21642987, 27240734, 28251928
GO:1904972	Process	Negative regulation of viral translation	IDA	27240734, 28251928

MIM	HGNC	e!Ensembl
147690	5407	ENSG00000185745

P09914

Protein name

Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1)

Protein function

Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNA

PDB

4HOU , 5UDI , 5UDJ , 5UDK , 5UDL , 5W5H , 5W5I , 6C6K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13424	TPR_12	51 → 127		Repeat
PF13181	TPR_8	154 → 174	Tetratricopeptide repeat	Repeat

Sequence

MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAY
VKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDK
VENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAG
YAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYI
EEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMI
QIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAE
ENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSIN
SLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAADFENSVRQGP

Sequence length

478

Interactions

View interactions

	KEGG		Reactome
	Hepatitis C		ISG15 antiviral mechanism Interferon alpha/beta signaling

IFIT1 (interferon induced protein with tetratricopeptide repeats 1)