Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	339896
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate decarboxylase like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GADL1
Synonyms (NCBI Gene) Gene synonyms aliases	ADC, CSADC, HuADC, HuCSADC
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p24.1-p23

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	24906430
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	23446348
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	23446348
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	23446348
MIRT516104	hsa-miR-3921	PAR-CLIP	23446348
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT516100	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	23446348
MIRT516097	hsa-miR-6089	PAR-CLIP	23446348
MIRT516096	hsa-miR-4320	PAR-CLIP	23446348
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT607370	hsa-miR-8485	HITS-CLIP	27418678
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT613531	hsa-miR-4311	HITS-CLIP	23824327
MIRT607370	hsa-miR-8485	HITS-CLIP	23824327
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	20371350
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	20371350
MIRT516104	hsa-miR-3921	PAR-CLIP	20371350
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	20371350
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT516100	hsa-miR-619-5p	PAR-CLIP	20371350
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	20371350
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT516097	hsa-miR-6089	PAR-CLIP	20371350
MIRT516096	hsa-miR-4320	PAR-CLIP	20371350
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT516108	hsa-miR-146a-3p	PAR-CLIP	23446348
MIRT516106	hsa-miR-301a-5p	PAR-CLIP	23446348
MIRT516105	hsa-miR-301b-5p	PAR-CLIP	23446348
MIRT516104	hsa-miR-3921	PAR-CLIP	23446348
MIRT516103	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT516101	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT516102	hsa-miR-7162-3p	PAR-CLIP	23446348
MIRT516100	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT516099	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT516098	hsa-miR-5008-5p	PAR-CLIP	23446348
MIRT516097	hsa-miR-6089	PAR-CLIP	23446348
MIRT516096	hsa-miR-4320	PAR-CLIP	23446348
MIRT516094	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT1010249	hsa-miR-125a-3p	CLIP-seq
MIRT1010250	hsa-miR-1915	CLIP-seq
MIRT1010251	hsa-miR-2113	CLIP-seq
MIRT1010252	hsa-miR-218	CLIP-seq
MIRT1010253	hsa-miR-2964a-5p	CLIP-seq
MIRT1010254	hsa-miR-329	CLIP-seq
MIRT1010255	hsa-miR-362-3p	CLIP-seq
MIRT1010256	hsa-miR-4502	CLIP-seq
MIRT1010257	hsa-miR-451b	CLIP-seq
MIRT1010258	hsa-miR-4726-3p	CLIP-seq
MIRT1010259	hsa-miR-4762-3p	CLIP-seq
MIRT1010260	hsa-miR-4766-3p	CLIP-seq
MIRT1999210	hsa-miR-3065-5p	CLIP-seq
MIRT1999211	hsa-miR-3924	CLIP-seq
MIRT1010257	hsa-miR-451b	CLIP-seq
MIRT1999212	hsa-miR-494	CLIP-seq
MIRT1999213	hsa-miR-505	CLIP-seq
MIRT2388348	hsa-miR-4481	CLIP-seq
MIRT2388349	hsa-miR-4745-5p	CLIP-seq
MIRT2388350	hsa-miR-759	CLIP-seq
MIRT2465340	hsa-miR-3121-5p	CLIP-seq
MIRT2465341	hsa-miR-3128	CLIP-seq
MIRT2465342	hsa-miR-4470	CLIP-seq
MIRT2388348	hsa-miR-4481	CLIP-seq
MIRT2388349	hsa-miR-4745-5p	CLIP-seq
MIRT2388350	hsa-miR-759	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence
GO:0004068	Function	Aspartate 1-decarboxylase activity	IEA
GO:0004782	Function	Sulfinoalanine decarboxylase activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016829	Function	Lyase activity	IEA
GO:0016830	Function	Carbon-carbon lyase activity	IEA
GO:0016831	Function	Carboxy-lyase activity	IBA
GO:0016831	Function	Carboxy-lyase activity	IEA
GO:0019752	Process	Carboxylic acid metabolic process	IEA
GO:0030170	Function	Pyridoxal phosphate binding	IEA

MIM	HGNC	e!Ensembl
615601	27949	ENSG00000144644

Protein

UniProt ID

Q6ZQY3

Protein name

Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)

Protein function

May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000269|Pu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00282	Pyridoxal_deC	77 → 445	Pyridoxal-dependent decarboxylase conserved domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed very weakly in neurons and not detected in astrocytes, brain or liver. {ECO:0000269|PubMed:26327310}.

Sequence

MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEV
VLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQ
LYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGG
SVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKAASFLGIGTENVCFVE
TDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHV
DASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAK
ASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLV
DEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLM
LGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM

Sequence length

521

Interactions

View interactions

	KEGG		Reactome
	beta-Alanine metabolism Taurine and hypotaurine metabolism Pantothenate and CoA biosynthesis Metabolic pathways		Degradation of cysteine and homocysteine Aspartate and asparagine metabolism

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Frontal Fibrosing Alopecia	Frontal fibrosing alopecia	N/A	N/A	GWAS
Takayasu Arteritis	Takayasu arteritis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bipolar Disorder	Associate	24369049, 30923325, 31767892
Idiopathic Hypogonadotropic Hypogonadism	Associate	33208564
Immune System Diseases	Associate	31767892
Inflammation	Associate	28355295
Neuroblastoma	Associate	30923325
Osteoarthritis	Associate	27974301
Tuberculosis Pulmonary	Associate	28355295

GADL1 (glutamate decarboxylase like 1)