CLEC4D (C-type lectin domain family 4 member D)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
338339 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
C-type lectin domain family 4 member D |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
CLEC4D |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CD368, CLEC-6, CLEC6, CLECSF8, Dectin-3, MCL, MPCL |
Chromosome
Chromosome number
|
12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12p13.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles |
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | |||||||||||
UniProt ID | Q8WXI8 | ||||||||||
Protein name | C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368) | ||||||||||
Protein function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602 | ||||||||||
PDB | 2LS8 , 3WHD | ||||||||||
Family and domains |
Pfam
|
||||||||||
Tissue specificity | TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}. | ||||||||||
Sequence |
|
||||||||||
Sequence length | 215 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||||||
|