Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	338339
Gene name	C-type lectin domain family 4 member D
Gene symbol	CLEC4D
Synonyms (NCBI Gene)	CD368CLEC-6CLEC6CLECSF8Dectin-3MCLMPCL
Chromosome	12
Chromosome location	12p13.31
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles

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Show/Hide all (282)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021599	hsa-miR-142-3p	Microarray	17612493
MIRT049934	hsa-miR-30a-5p	CLASH	23622248
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT530827	hsa-miR-3653-3p	PAR-CLIP	22012620
MIRT530826	hsa-miR-4477a	PAR-CLIP	22012620
MIRT530824	hsa-miR-3658	PAR-CLIP	22012620
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT611584	hsa-miR-8485	HITS-CLIP	23824327
MIRT611583	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611582	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611581	hsa-miR-603	HITS-CLIP	23824327
MIRT611580	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611579	hsa-miR-4643	HITS-CLIP	23824327
MIRT611578	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT611577	hsa-miR-3941	HITS-CLIP	23824327
MIRT611576	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT530827	hsa-miR-3653-3p	PAR-CLIP	22012620
MIRT530826	hsa-miR-4477a	PAR-CLIP	22012620
MIRT530824	hsa-miR-3658	PAR-CLIP	22012620
MIRT896035	hsa-miR-134	CLIP-seq
MIRT896036	hsa-miR-203	CLIP-seq
MIRT896037	hsa-miR-2054	CLIP-seq
MIRT896038	hsa-miR-30a	CLIP-seq
MIRT896039	hsa-miR-30b	CLIP-seq
MIRT896040	hsa-miR-30c	CLIP-seq
MIRT896041	hsa-miR-30d	CLIP-seq
MIRT896042	hsa-miR-30e	CLIP-seq
MIRT896043	hsa-miR-3118	CLIP-seq
MIRT896044	hsa-miR-3121-5p	CLIP-seq
MIRT896045	hsa-miR-3136-5p	CLIP-seq
MIRT896046	hsa-miR-3164	CLIP-seq
MIRT896047	hsa-miR-380	CLIP-seq
MIRT896048	hsa-miR-4439	CLIP-seq
MIRT896049	hsa-miR-4501	CLIP-seq
MIRT896050	hsa-miR-4513	CLIP-seq
MIRT896051	hsa-miR-4764-5p	CLIP-seq
MIRT896052	hsa-miR-561	CLIP-seq
MIRT896053	hsa-miR-938	CLIP-seq
MIRT1965650	hsa-miR-1238	CLIP-seq
MIRT1965651	hsa-miR-450b-5p	CLIP-seq
MIRT1965652	hsa-miR-518a-5p	CLIP-seq
MIRT1965653	hsa-miR-527	CLIP-seq
MIRT1965654	hsa-miR-610	CLIP-seq
MIRT2201599	hsa-miR-3124-3p	CLIP-seq
MIRT2201600	hsa-miR-4753-3p	CLIP-seq
MIRT2201601	hsa-miR-4768-5p	CLIP-seq
MIRT2201602	hsa-miR-587	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002292	Process	T cell differentiation involved in immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	23911656, 25910212, 32296183
GO:0005537	Function	D-mannose binding	IDA	23911656
GO:0005886	Component	Plasma membrane	IDA	23911656
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IBA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030887	Process	Positive regulation of myeloid dendritic cell activation	IEA
GO:0030887	Process	Positive regulation of myeloid dendritic cell activation	ISS
GO:0034987	Function	Immunoglobulin receptor binding	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0038094	Process	Fc-gamma receptor signaling pathway	IEA
GO:0038187	Function	Pattern recognition receptor activity	IBA
GO:0038187	Function	Pattern recognition receptor activity	IDA	23911656
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061760	Process	Antifungal innate immune response	IBA
GO:0061760	Process	Antifungal innate immune response	IDA	23911656
GO:0061760	Process	Antifungal innate immune response	IEA
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

MIM	HGNC	e!Ensembl
609964	14554	ENSG00000166527

Q8WXI8

Protein name

C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)

Protein function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602

PDB

2LS8 , 3WHD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	101 → 209	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}.

Sequence

MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEH
HAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLM
TISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGE
NCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN

Sequence length

215

Interactions

View interactions

	KEGG		Reactome
	C-type lectin receptor signaling pathway		Dectin-2 family Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LUNG DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alopecia Areata	Associate	39459398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Associate	35178459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	27099439	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	20846378	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Associate	36688193	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	36140771, 40340571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Embolic Stroke	Associate	35075378	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C	Associate	32292405	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Associate	12824192	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infections	Associate	37766307	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	37548663	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases Interstitial	Associate	36979470	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	36979470	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Mantle Cell	Associate	29472356	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	37991344	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Associate	32594092	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Associate	22234694	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non alcoholic Fatty Liver Disease	Associate	32594092	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Associate	36979470	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	34313877	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease Type 1	Associate	29389944	★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC4D (C-type lectin domain family 4 member D)