Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3326
Gene name	Heat shock protein 90 alpha family class B member 1
Gene symbol	HSP90AB1
Synonyms (NCBI Gene)	D6S182HSP84HSP90BHSPC2HSPCB
Chromosome	6
Chromosome location	6p21.1
Summary	This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016366	hsa-miR-193b-3p	Proteomics	21512034
MIRT049288	hsa-miR-92a-3p	CLASH	23622248
MIRT046508	hsa-miR-15b-5p	CLASH	23622248
MIRT044926	hsa-miR-186-5p	CLASH	23622248
MIRT044757	hsa-miR-320a	CLASH	23622248
MIRT041702	hsa-miR-484	CLASH	23622248
MIRT041702	hsa-miR-484	CLASH	23622248
MIRT041164	hsa-miR-181d-5p	CLASH	23622248
MIRT041138	hsa-miR-501-5p	CLASH	23622248
MIRT039893	hsa-miR-615-3p	CLASH	23622248
MIRT039893	hsa-miR-615-3p	CLASH	23622248
MIRT038803	hsa-miR-93-3p	CLASH	23622248
MIRT038803	hsa-miR-93-3p	CLASH	23622248
MIRT038357	hsa-miR-296-3p	CLASH	23622248
MIRT037860	hsa-miR-455-3p	CLASH	23622248
MIRT037004	hsa-miR-877-3p	CLASH	23622248
MIRT037004	hsa-miR-877-3p	CLASH	23622248
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	20371350
MIRT488267	hsa-miR-335-5p	PAR-CLIP	20371350
MIRT499217	hsa-miR-370-3p	PAR-CLIP	20371350
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	20371350
MIRT488266	hsa-miR-626	PAR-CLIP	20371350
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	20371350
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT488262	hsa-miR-4489	PAR-CLIP	20371350
MIRT488263	hsa-miR-4283	PAR-CLIP	20371350
MIRT488261	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT540125	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT540124	hsa-miR-4801	PAR-CLIP	21572407
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	21572407
MIRT488267	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT540123	hsa-miR-5003-5p	PAR-CLIP	21572407
MIRT499217	hsa-miR-370-3p	PAR-CLIP	21572407
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	21572407
MIRT488266	hsa-miR-626	PAR-CLIP	21572407
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	21572407
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	23446348
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	23446348
MIRT488267	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT499217	hsa-miR-370-3p	PAR-CLIP	23446348
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	23446348
MIRT488266	hsa-miR-626	PAR-CLIP	23446348
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	23446348
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT488262	hsa-miR-4489	PAR-CLIP	23446348
MIRT488263	hsa-miR-4283	PAR-CLIP	23446348
MIRT488261	hsa-miR-185-3p	PAR-CLIP	23446348
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	24398324
MIRT488267	hsa-miR-335-5p	PAR-CLIP	24398324
MIRT499217	hsa-miR-370-3p	PAR-CLIP	24398324
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	24398324
MIRT488266	hsa-miR-626	PAR-CLIP	24398324
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	24398324
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	24398324
MIRT488262	hsa-miR-4489	PAR-CLIP	24398324
MIRT488263	hsa-miR-4283	PAR-CLIP	24398324
MIRT488261	hsa-miR-185-3p	PAR-CLIP	24398324
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	24398324
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	23592263
MIRT488267	hsa-miR-335-5p	PAR-CLIP	23592263
MIRT488266	hsa-miR-626	PAR-CLIP	23592263
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	23592263
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT488262	hsa-miR-4489	PAR-CLIP	23592263
MIRT488263	hsa-miR-4283	PAR-CLIP	23592263
MIRT488261	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT488261	hsa-miR-185-3p	PAR-CLIP	26701625
MIRT488267	hsa-miR-335-5p	PAR-CLIP	26701625
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	26701625
MIRT488263	hsa-miR-4283	PAR-CLIP	26701625
MIRT488262	hsa-miR-4489	PAR-CLIP	26701625
MIRT488266	hsa-miR-626	PAR-CLIP	26701625
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	26701625
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	26701625
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	26701625
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	26701625
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	20371350
MIRT488267	hsa-miR-335-5p	PAR-CLIP	20371350
MIRT499217	hsa-miR-370-3p	PAR-CLIP	20371350
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	20371350
MIRT488266	hsa-miR-626	PAR-CLIP	20371350
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	20371350
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT488262	hsa-miR-4489	PAR-CLIP	20371350
MIRT488263	hsa-miR-4283	PAR-CLIP	20371350
MIRT488261	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT540125	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT540124	hsa-miR-4801	PAR-CLIP	21572407
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	21572407
MIRT488267	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT540123	hsa-miR-5003-5p	PAR-CLIP	21572407
MIRT499217	hsa-miR-370-3p	PAR-CLIP	21572407
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	21572407
MIRT488266	hsa-miR-626	PAR-CLIP	21572407
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	21572407
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	23446348
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	23446348
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	23446348
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	23446348
MIRT488267	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT499217	hsa-miR-370-3p	PAR-CLIP	23446348
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	23446348
MIRT488266	hsa-miR-626	PAR-CLIP	23446348
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	23446348
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT488262	hsa-miR-4489	PAR-CLIP	23446348
MIRT488263	hsa-miR-4283	PAR-CLIP	23446348
MIRT488261	hsa-miR-185-3p	PAR-CLIP	23446348
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	24398324
MIRT488267	hsa-miR-335-5p	PAR-CLIP	24398324
MIRT499217	hsa-miR-370-3p	PAR-CLIP	24398324
MIRT499216	hsa-miR-6893-3p	PAR-CLIP	24398324
MIRT488266	hsa-miR-626	PAR-CLIP	24398324
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	24398324
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	24398324
MIRT488262	hsa-miR-4489	PAR-CLIP	24398324
MIRT488263	hsa-miR-4283	PAR-CLIP	24398324
MIRT488261	hsa-miR-185-3p	PAR-CLIP	24398324
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	24398324
MIRT488271	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488270	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488269	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT488268	hsa-miR-3675-5p	PAR-CLIP	23592263
MIRT488267	hsa-miR-335-5p	PAR-CLIP	23592263
MIRT488266	hsa-miR-626	PAR-CLIP	23592263
MIRT488265	hsa-miR-6876-3p	PAR-CLIP	23592263
MIRT488264	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT488262	hsa-miR-4489	PAR-CLIP	23592263
MIRT488263	hsa-miR-4283	PAR-CLIP	23592263
MIRT488261	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT488260	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055873	hsa-miR-3148	CLIP-seq
MIRT1055874	hsa-miR-3163	CLIP-seq
MIRT1055875	hsa-miR-3185	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055877	hsa-miR-335	CLIP-seq
MIRT1055878	hsa-miR-3646	CLIP-seq
MIRT1055879	hsa-miR-370	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055883	hsa-miR-4668-5p	CLIP-seq
MIRT1055884	hsa-miR-4680-5p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT1055886	hsa-miR-514	CLIP-seq
MIRT1055887	hsa-miR-514b-3p	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1549642	hsa-miR-153	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT1549643	hsa-miR-448	CLIP-seq
MIRT1549644	hsa-miR-450b-5p	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1549645	hsa-miR-507	CLIP-seq
MIRT1549646	hsa-miR-557	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1549642	hsa-miR-153	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055873	hsa-miR-3148	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055877	hsa-miR-335	CLIP-seq
MIRT1055879	hsa-miR-370	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT2012819	hsa-miR-421	CLIP-seq
MIRT2012820	hsa-miR-4297	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT2012821	hsa-miR-4457	CLIP-seq
MIRT1549643	hsa-miR-448	CLIP-seq
MIRT1549644	hsa-miR-450b-5p	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055883	hsa-miR-4668-5p	CLIP-seq
MIRT1055884	hsa-miR-4680-5p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT2012822	hsa-miR-4768-3p	CLIP-seq
MIRT1549645	hsa-miR-507	CLIP-seq
MIRT1549646	hsa-miR-557	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055873	hsa-miR-3148	CLIP-seq
MIRT1055874	hsa-miR-3163	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055877	hsa-miR-335	CLIP-seq
MIRT1055879	hsa-miR-370	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT2012819	hsa-miR-421	CLIP-seq
MIRT2012820	hsa-miR-4297	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT2012821	hsa-miR-4457	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055883	hsa-miR-4668-5p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT2012822	hsa-miR-4768-3p	CLIP-seq
MIRT1055886	hsa-miR-514	CLIP-seq
MIRT1055887	hsa-miR-514b-3p	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055877	hsa-miR-335	CLIP-seq
MIRT1055879	hsa-miR-370	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT2012819	hsa-miR-421	CLIP-seq
MIRT2012820	hsa-miR-4297	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT1055886	hsa-miR-514	CLIP-seq
MIRT1055887	hsa-miR-514b-3p	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq
MIRT1055879	hsa-miR-370	CLIP-seq
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055873	hsa-miR-3148	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT2012819	hsa-miR-421	CLIP-seq
MIRT2012820	hsa-miR-4297	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT2012821	hsa-miR-4457	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055883	hsa-miR-4668-5p	CLIP-seq
MIRT1055884	hsa-miR-4680-5p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT2012822	hsa-miR-4768-3p	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq
MIRT1055868	hsa-miR-1226	CLIP-seq
MIRT1055869	hsa-miR-1284	CLIP-seq
MIRT1055870	hsa-miR-1909	CLIP-seq
MIRT1055871	hsa-miR-214	CLIP-seq
MIRT1055872	hsa-miR-300	CLIP-seq
MIRT1055873	hsa-miR-3148	CLIP-seq
MIRT1055876	hsa-miR-3191	CLIP-seq
MIRT1055880	hsa-miR-381	CLIP-seq
MIRT2012819	hsa-miR-421	CLIP-seq
MIRT2012820	hsa-miR-4297	CLIP-seq
MIRT1055881	hsa-miR-4305	CLIP-seq
MIRT2012821	hsa-miR-4457	CLIP-seq
MIRT1055882	hsa-miR-4666-3p	CLIP-seq
MIRT1055883	hsa-miR-4668-5p	CLIP-seq
MIRT1055885	hsa-miR-4704-5p	CLIP-seq
MIRT2012822	hsa-miR-4768-3p	CLIP-seq
MIRT1055888	hsa-miR-624	CLIP-seq
MIRT1055889	hsa-miR-939	CLIP-seq

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Transcription factor	Regulation	Reference
TP53	Repression	15284248

117

Show/Hide all (117)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001890	Process	Placenta development	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0005515	Function	Protein binding	IPI	11036079, 14743216, 15358771, 15581363, 15657067, 15870294, 16293251, 16314389, 16330544, 16531226, 16580629, 16698020, 17932509, 17979178, 18239673, 18320024, 18818696, 19375531, 20029029, 20374249, 20618441, 20650008, 21145461, 21170051, 21183720, 21360678, 21730179, 21988832, 220
GO:0005524	Function	ATP binding	IBA
GO:0005524	Function	ATP binding	IDA	10811660
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	IMP	10543959
GO:0005576	Component	Extracellular region	IDA	20599762
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	18239673
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	10791971, 11785981, 16580629, 18239673, 24880080
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	ISS	17517623
GO:0006986	Process	Response to unfolded protein	NAS	2768249
GO:0007004	Process	Telomere maintenance via telomerase	IDA	10197982
GO:0007004	Process	Telomere maintenance via telomerase	IEA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0016887	Function	ATP hydrolysis activity	TAS
GO:0019062	Process	Virion attachment to host cell	IMP	24098578
GO:0019887	Function	Protein kinase regulator activity	IEA
GO:0019900	Function	Kinase binding	IEA
GO:0019900	Function	Kinase binding	IPI	20353823, 21855797
GO:0019901	Function	Protein kinase binding	IEA
GO:0023026	Function	MHC class II protein complex binding	HDA	20458337
GO:0030235	Function	Nitric-oxide synthase regulator activity	ISS
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IDA	24613385
GO:0030911	Function	TPR domain binding	ISS
GO:0031072	Function	Heat shock protein binding	IPI	20353823
GO:0031396	Process	Regulation of protein ubiquitination	IDA	16809764
GO:0031396	Process	Regulation of protein ubiquitination	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	16207813
GO:0032435	Process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	24613385
GO:0032880	Process	Regulation of protein localization	IEA
GO:0032880	Process	Regulation of protein localization	ISS
GO:0032991	Component	Protein-containing complex	IBA
GO:0032991	Component	Protein-containing complex	IDA	10811660, 23349634
GO:0032991	Component	Protein-containing complex	IEA
GO:0032991	Component	Protein-containing complex	IMP	10543959
GO:0034605	Process	Cellular response to heat	IBA
GO:0034605	Process	Cellular response to heat	IEA
GO:0034751	Component	Aryl hydrocarbon receptor complex	IDA	15581363
GO:0034774	Component	Secretory granule lumen	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042277	Function	Peptide binding	IPI	20599762
GO:0042470	Component	Melanosome	IEA
GO:0042802	Function	Identical protein binding	IPI	21183720, 22939624, 30382094
GO:0042803	Function	Protein homodimerization activity	IDA	10811660
GO:0042826	Function	Histone deacetylase binding	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	16809764
GO:0043008	Function	ATP-dependent protein binding	IPI	10543959, 10811660
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0044183	Function	Protein folding chaperone	IEA
GO:0044183	Function	Protein folding chaperone	ISS	17517623
GO:0044294	Component	Dendritic growth cone	IEA
GO:0044294	Component	Dendritic growth cone	ISS
GO:0044295	Component	Axonal growth cone	IEA
GO:0044295	Component	Axonal growth cone	ISS
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	ISS
GO:0045597	Process	Positive regulation of cell differentiation	IMP	18239673
GO:0046983	Function	Protein dimerization activity	IDA	7588731
GO:0048156	Function	Tau protein binding	IEA
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0050821	Process	Protein stabilization	IBA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051131	Process	Chaperone-mediated protein complex assembly	IDA	10811660
GO:0051131	Process	Chaperone-mediated protein complex assembly	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	22843495
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0070182	Function	DNA polymerase binding	IEA
GO:0070182	Function	DNA polymerase binding	IPI	10197982, 19751963
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:0072542	Function	Protein phosphatase activator activity	IDA	26593036
GO:0097435	Process	Supramolecular fiber organization	IMP	24466266
GO:0097718	Function	Disordered domain specific binding	IEA
GO:0097718	Function	Disordered domain specific binding	IPI	11785981, 15713458
GO:0101031	Component	Protein folding chaperone complex	IEA
GO:0101031	Component	Protein folding chaperone complex	IMP	17517623
GO:0120293	Component	Dynein axonemal particle	IEA
GO:0120293	Component	Dynein axonemal particle	ISS
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA
GO:0141069	Function	Receptor ligand inhibitor activity	IDA	20599762
GO:1901799	Process	Negative regulation of proteasomal protein catabolic process	IEA
GO:1901799	Process	Negative regulation of proteasomal protein catabolic process	ISS	17517623
GO:1904813	Component	Ficolin-1-rich granule lumen	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:1905323	Process	Telomerase holoenzyme complex assembly	IDA	10197982
GO:1905323	Process	Telomerase holoenzyme complex assembly	IEA
GO:1990226	Function	Histone methyltransferase binding	IPI	24880080
GO:1990565	Component	HSP90-CDC37 chaperone complex	IDA	21855797
GO:1990565	Component	HSP90-CDC37 chaperone complex	IEA
GO:2000010	Process	Positive regulation of protein localization to cell surface	IDA	23431407

MIM	HGNC	e!Ensembl
140572	5258	ENSG00000096384

P08238

Protein name

Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)

Protein function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase act

PDB

1QZ2 , 1UYM , 2L6J , 3FWV , 3NMQ , 3PRY , 3UQ3 , 5FWK , 5FWL , 5FWM , 5FWP , 5UC4 , 5UCH , 5UCI , 5UCJ , 6N8W , 6N8Y , 7ULJ , 7Z37 , 7Z38 , 7ZR0 , 7ZR5 , 7ZR6 , 7ZUB , 8EOA , 8EOB , 8GAE , 8GFT , 8QMO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02518	HATPase_c	35 → 189	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
PF00183	HSP90	191 → 712	Hsp90 protein	Family

Sequence

MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD

Sequence length

724

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis Antigen processing and presentation NOD-like receptor signaling pathway IL-17 signaling pathway Th17 cell differentiation Progesterone-mediated oocyte maturation Estrogen signaling pathway Salmonella infection Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis		Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Purinergic signaling in leishmaniasis infection

HSP90AB1 (heat shock protein 90 alpha family class B member 1)