Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
332
Gene name Gene Name - the full gene name approved by the HGNC.
Baculoviral IAP repeat containing 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BIRC5
Synonyms (NCBI Gene) Gene synonyms aliases
API4, EPR-1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005363 hsa-miR-542-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20728447
MIRT006046 hsa-miR-218-5p Immunoblot, Luciferase reporter assay, Microarray, qRT-PCR 21385904
MIRT006141 hsa-miR-708-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21852381
MIRT006141 hsa-miR-708-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21852381
MIRT006141 hsa-miR-708-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21852381
Transcription factors
Transcription factor Regulation Reference
APC Unknown 11751382
CTNNB1 Unknown 19662654;19778454
DNMT1 Repression 17124180
E2F1 Activation 17848598;19102934
E2F1 Repression 19102934
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 9859993
GO:0000228 Component Nuclear chromosome IDA 16322459
GO:0000278 Process Mitotic cell cycle NAS 17956729
GO:0000278 Process Mitotic cell cycle TAS 16291752
GO:0000281 Process Mitotic cytokinesis IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603352 593 ENSG00000089685
Protein
UniProt ID O15392
Protein name Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Protein function Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which
PDB 1E31 , 1F3H , 1XOX , 2QFA , 2RAW , 2RAX , 3UEC , 3UED , 3UEE , 3UEF , 3UEG , 3UEH , 3UEI , 3UIG , 3UIH , 3UII , 3UIJ , 3UIK , 4A0I , 4A0J , 4A0N , 6SHO , 6YIE , 6YIF , 6YIH , 7LBK , 7LBO , 7LBP , 7LBQ , 8RUP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00653 BIR 18 88 Inhibitor of Apoptosis domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed
Sequence
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLS
VKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD
Sequence length 142
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Platinum drug resistance
Apoptosis
Apoptosis - multiple species
Hippo signaling pathway
Hepatitis B
Pathways in cancer
Chemical carcinogenesis - receptor activation
Colorectal cancer
  Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation
EML4 and NUDC in mitotic spindle formation
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