Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3308
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein family A (Hsp70) member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSPA4
Synonyms (NCBI Gene) Gene synonyms aliases
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Review 19815577
Transcription factors
Transcription factor Regulation Reference
CEBPA Activation 2247079
CREG1 Repression 9710587
HSF1 Activation 12813038;23349863;8114740;8455624
HSF1 Unknown 1508207;15777846;16554822;22940245;23264262
HSF2 Activation 12813038;8114740
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20029029, 22990239, 24658140, 25416956, 29568061, 30021884, 31980649, 32296183
GO:0005524 Function ATP binding NAS 8335910
GO:0005634 Component Nucleus IBA 21873635
GO:0005739 Component Mitochondrion IEA
GO:0005829 Component Cytosol IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601113 5237 ENSG00000170606
Protein
UniProt ID P34932
Protein name Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 3 607 Hsp70 protein Family
PF00012 HSP70 586 691 Hsp70 protein Family
Sequence
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNA
KNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAM
LLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALA
YGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVL
VNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT
MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGK
ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVF
SKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKV
KVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPA
ENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQL
LWQIDREMLNLYIEN
EGKMIMQ
DKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLY
EDGEDQPKQVYVDKLAELKNLGQPIKIRFQE
SEERPKLFEELGKQIQQYMKIISSFKNKE
DQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCS
PIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID
Sequence length 840
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Tight junction
Antigen processing and presentation
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Facioscapulohumeral muscular dystrophy Muscular Dystrophy, Facioscapulohumeral rs387907319, rs397514623, rs1057519614, rs1598416221, rs886041918, rs886042417, rs1057519644, rs1245372794, rs1555642277, rs1555644339, rs1555647265, rs886044369, rs1568350731, rs377471712, rs2075161300
View all (2 more)
12868502
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 30804561 ClinVar
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Uterine Fibroids Uterine Fibroids GWAS
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 34884786
Acquired ichthyosis Associate 36303457
Adenocarcinoma Associate 27491302
Adenocarcinoma of Lung Associate 32221746
Adenoma Associate 23196783
Agranulocytosis Associate 7579351, 9166860
AIDS Associated Nephropathy Associate 31805958
Alopecia Areata Associate 29323127
Alzheimer Disease Associate 21403392
Ameloblastoma Associate 33395399