Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3308
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein family A (Hsp70) member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSPA4
Synonyms (NCBI Gene) Gene synonyms aliases
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Luciferase reporter assay 17715156
MIRT003977 hsa-miR-1-3p Review 19815577
Transcription factors
Transcription factor Regulation Reference
CEBPA Activation 2247079
CREG1 Repression 9710587
HSF1 Activation 12813038;23349863;8114740;8455624
HSF1 Unknown 1508207;15777846;16554822;22940245;23264262
HSF2 Activation 12813038;8114740
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000774 Function Adenyl-nucleotide exchange factor activity IBA
GO:0005515 Function Protein binding IPI 20029029, 22990239, 24658140, 25416956, 29568061, 30021884, 31980649, 32296183, 33961781
GO:0005524 Function ATP binding IEA
GO:0005524 Function ATP binding NAS 8335910
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601113 5237 ENSG00000170606
Protein
UniProt ID P34932
Protein name Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 3 607 Hsp70 protein Family
PF00012 HSP70 586 691 Hsp70 protein Family
Sequence
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNA
KNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAM
LLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALA
YGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVL
VNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT
MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGK
ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVF
SKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKV
KVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPA
ENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQL
LWQIDREMLNLYIEN
EGKMIMQ
DKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLY
EDGEDQPKQVYVDKLAELKNLGQPIKIRFQE
SEERPKLFEELGKQIQQYMKIISSFKNKE
DQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCS
PIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID
Sequence length 840
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Tight junction
Antigen processing and presentation
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Hypertension Hypertension (PheCode 401), Essential hypertension (PheCode 401.1) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 34884786
Acquired ichthyosis Associate 36303457
Adenocarcinoma Associate 27491302
Adenocarcinoma of Lung Associate 32221746
Adenoma Associate 23196783
Agranulocytosis Associate 7579351, 9166860
AIDS Associated Nephropathy Associate 31805958
Alopecia Areata Associate 29323127
Alzheimer Disease Associate 21403392
Ameloblastoma Associate 33395399