Gene Gene information from NCBI Gene database.
Entrez ID 3281
Gene name Heat shock factor binding protein 1
Gene symbol HSBP1
Synonyms (NCBI Gene)
NPC-A-13
Chromosome 16
Chromosome location 16q23.3
Summary The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), i
miRNA miRNA information provided by mirtarbase database.
737
miRTarBase ID miRNA Experiments Reference
MIRT709021 hsa-miR-4687-5p HITS-CLIP 19536157
MIRT709020 hsa-miR-4690-3p HITS-CLIP 19536157
MIRT709019 hsa-miR-5685 HITS-CLIP 19536157
MIRT709018 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT709017 hsa-miR-3157-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 9649501
GO:0003714 Function Transcription corepressor activity IEA
GO:0003714 Function Transcription corepressor activity TAS 9649501
GO:0005515 Function Protein binding IPI 16189514, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604553 5203 ENSG00000230989
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75506
Protein name Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)
Protein function Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
PDB 3CI9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06825 HSBP1 10 60 Heat shock factor binding protein 1 Coiled-coil
Sequence
Sequence length 76
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HSF1 activation
Attenuation phase
HSF1-dependent transactivation