HSBP1 (heat shock factor binding protein 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3281
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock factor binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSBP1
Synonyms (NCBI Gene) Gene synonyms aliases
NPC-A-13
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(737)
miRTarBase ID miRNA Experiments Reference
MIRT709021 hsa-miR-4687-5p HITS-CLIP 19536157
MIRT709020 hsa-miR-4690-3p HITS-CLIP 19536157
MIRT709019 hsa-miR-5685 HITS-CLIP 19536157
MIRT709018 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT709017 hsa-miR-3157-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 9649501
GO:0003714 Function Transcription corepressor activity IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 28514442, 29892012, 31515488, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604553 5203 ENSG00000230989
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O75506
Protein name Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)
Protein function Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
PDB 3CI9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06825 HSBP1 10 → 60 Heat shock factor binding protein 1 Coiled-coil
Sequence
Sequence length 76
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 26503814 ClinVar
Neuroblastoma Neuroblastoma Loss of SNAI2 function reduces self-renewal, 3D invasion as well as metastatic spread in vivo, while strongly sensitizing neuroblastoma cells to RA-induced growth inhibition. GWAS, CBGDA
Show/Hide Text Mining Associations (1)
Associations from Text Mining
Disease Name Relationship Type References
Hearing Loss Associate 22258528