AGFG2 (ArfGAP with FG repeats 2)

Gene

• Entrez ID: 3268
• Gene name: ArfGAP with FG repeats 2
• Gene symbol: AGFG2
• Synonyms (NCBI Gene): HRBL, RABR
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and play

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018284	hsa-miR-335-5p	Microarray	18185580
MIRT052062	hsa-let-7b-5p	CLASH	23622248
MIRT042987	hsa-miR-324-3p	CLASH	23622248
MIRT169669	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT169663	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT169669	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT169662	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT169682	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT169664	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT169693	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT169663	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT771869	hsa-miR-106a	CLIP-seq
MIRT771870	hsa-miR-106b	CLIP-seq
MIRT771871	hsa-miR-1225-3p	CLIP-seq
MIRT771872	hsa-miR-1226	CLIP-seq
MIRT771873	hsa-miR-1231	CLIP-seq
MIRT771874	hsa-miR-1233	CLIP-seq
MIRT771875	hsa-miR-1237	CLIP-seq
MIRT771876	hsa-miR-1245b-5p	CLIP-seq
MIRT771877	hsa-miR-1254	CLIP-seq
MIRT771878	hsa-miR-125a-3p	CLIP-seq
MIRT771879	hsa-miR-1262	CLIP-seq
MIRT771880	hsa-miR-1266	CLIP-seq
MIRT771881	hsa-miR-1273e	CLIP-seq
MIRT771882	hsa-miR-1321	CLIP-seq
MIRT771883	hsa-miR-1343	CLIP-seq
MIRT771884	hsa-miR-136	CLIP-seq
MIRT771885	hsa-miR-141	CLIP-seq
MIRT771886	hsa-miR-1537	CLIP-seq
MIRT771887	hsa-miR-1538	CLIP-seq
MIRT771888	hsa-miR-17	CLIP-seq
MIRT771889	hsa-miR-193a-5p	CLIP-seq
MIRT771890	hsa-miR-200a	CLIP-seq
MIRT771891	hsa-miR-20a	CLIP-seq
MIRT771892	hsa-miR-20b	CLIP-seq
MIRT771893	hsa-miR-2278	CLIP-seq
MIRT771894	hsa-miR-2861	CLIP-seq
MIRT771895	hsa-miR-297	CLIP-seq
MIRT771896	hsa-miR-302a	CLIP-seq
MIRT771897	hsa-miR-302b	CLIP-seq
MIRT771898	hsa-miR-302c	CLIP-seq
MIRT771899	hsa-miR-302d	CLIP-seq
MIRT771900	hsa-miR-302e	CLIP-seq
MIRT771901	hsa-miR-3074-5p	CLIP-seq
MIRT771902	hsa-miR-3116	CLIP-seq
MIRT771903	hsa-miR-3120-5p	CLIP-seq
MIRT771904	hsa-miR-3129-3p	CLIP-seq
MIRT771905	hsa-miR-3142	CLIP-seq
MIRT771906	hsa-miR-3163	CLIP-seq
MIRT771907	hsa-miR-3169	CLIP-seq
MIRT771908	hsa-miR-3176	CLIP-seq
MIRT771909	hsa-miR-3184	CLIP-seq
MIRT771910	hsa-miR-3192	CLIP-seq
MIRT771911	hsa-miR-3200-5p	CLIP-seq
MIRT771912	hsa-miR-3545-5p	CLIP-seq
MIRT771913	hsa-miR-3609	CLIP-seq
MIRT771914	hsa-miR-3614-5p	CLIP-seq
MIRT771915	hsa-miR-3622a-3p	CLIP-seq
MIRT771916	hsa-miR-3622b-3p	CLIP-seq
MIRT771917	hsa-miR-3650	CLIP-seq
MIRT771918	hsa-miR-3663-5p	CLIP-seq
MIRT771919	hsa-miR-3664-3p	CLIP-seq
MIRT771920	hsa-miR-3714	CLIP-seq
MIRT771921	hsa-miR-372	CLIP-seq
MIRT771922	hsa-miR-373	CLIP-seq
MIRT771923	hsa-miR-378g	CLIP-seq
MIRT771924	hsa-miR-3922-3p	CLIP-seq
MIRT771925	hsa-miR-3924	CLIP-seq
MIRT771926	hsa-miR-3978	CLIP-seq
MIRT771927	hsa-miR-423-5p	CLIP-seq
MIRT771928	hsa-miR-425	CLIP-seq
MIRT771929	hsa-miR-4300	CLIP-seq
MIRT771930	hsa-miR-4314	CLIP-seq
MIRT771931	hsa-miR-4436a	CLIP-seq
MIRT771932	hsa-miR-4455	CLIP-seq
MIRT771933	hsa-miR-4505	CLIP-seq
MIRT771934	hsa-miR-4518	CLIP-seq
MIRT771935	hsa-miR-455-5p	CLIP-seq
MIRT771936	hsa-miR-4640-5p	CLIP-seq
MIRT771937	hsa-miR-4643	CLIP-seq
MIRT771938	hsa-miR-4646-5p	CLIP-seq
MIRT771939	hsa-miR-4649-3p	CLIP-seq
MIRT771940	hsa-miR-4650-5p	CLIP-seq
MIRT771941	hsa-miR-4683	CLIP-seq
MIRT771942	hsa-miR-4701-3p	CLIP-seq
MIRT771943	hsa-miR-4717-3p	CLIP-seq
MIRT771944	hsa-miR-4722-3p	CLIP-seq
MIRT771945	hsa-miR-4726-3p	CLIP-seq
MIRT771946	hsa-miR-4726-5p	CLIP-seq
MIRT771947	hsa-miR-4728-5p	CLIP-seq
MIRT771948	hsa-miR-4733-3p	CLIP-seq
MIRT771949	hsa-miR-4739	CLIP-seq
MIRT771950	hsa-miR-4742-5p	CLIP-seq
MIRT771951	hsa-miR-4745-3p	CLIP-seq
MIRT771952	hsa-miR-4755-3p	CLIP-seq
MIRT771953	hsa-miR-4756-5p	CLIP-seq
MIRT771954	hsa-miR-4774-5p	CLIP-seq
MIRT771955	hsa-miR-4795-5p	CLIP-seq
MIRT771956	hsa-miR-4796-3p	CLIP-seq
MIRT771957	hsa-miR-483-3p	CLIP-seq
MIRT771958	hsa-miR-515-5p	CLIP-seq
MIRT771959	hsa-miR-516a-3p	CLIP-seq
MIRT771960	hsa-miR-519d	CLIP-seq
MIRT771961	hsa-miR-520a-3p	CLIP-seq
MIRT771962	hsa-miR-520b	CLIP-seq
MIRT771963	hsa-miR-520c-3p	CLIP-seq
MIRT771964	hsa-miR-520d-3p	CLIP-seq
MIRT771965	hsa-miR-520e	CLIP-seq
MIRT771966	hsa-miR-520f	CLIP-seq
MIRT771967	hsa-miR-548ah	CLIP-seq
MIRT771968	hsa-miR-548an	CLIP-seq
MIRT771969	hsa-miR-555	CLIP-seq
MIRT771970	hsa-miR-567	CLIP-seq
MIRT771971	hsa-miR-609	CLIP-seq
MIRT771972	hsa-miR-635	CLIP-seq
MIRT771973	hsa-miR-636	CLIP-seq
MIRT771974	hsa-miR-642b	CLIP-seq
MIRT771975	hsa-miR-661	CLIP-seq
MIRT771976	hsa-miR-920	CLIP-seq
MIRT771977	hsa-miR-93	CLIP-seq
MIRT771978	hsa-miR-940	CLIP-seq
MIRT771878	hsa-miR-125a-3p	CLIP-seq
MIRT771882	hsa-miR-1321	CLIP-seq
MIRT771883	hsa-miR-1343	CLIP-seq
MIRT771884	hsa-miR-136	CLIP-seq
MIRT771886	hsa-miR-1537	CLIP-seq
MIRT771887	hsa-miR-1538	CLIP-seq
MIRT1927775	hsa-miR-182	CLIP-seq
MIRT1927776	hsa-miR-1915	CLIP-seq
MIRT1927777	hsa-miR-2110	CLIP-seq
MIRT1927778	hsa-miR-2355-5p	CLIP-seq
MIRT1927779	hsa-miR-2467-3p	CLIP-seq
MIRT1927780	hsa-miR-3135b	CLIP-seq
MIRT1927781	hsa-miR-3148	CLIP-seq
MIRT1927782	hsa-miR-3178	CLIP-seq
MIRT1927783	hsa-miR-3652	CLIP-seq
MIRT1927784	hsa-miR-4271	CLIP-seq
MIRT1927785	hsa-miR-4284	CLIP-seq
MIRT1927786	hsa-miR-4312	CLIP-seq
MIRT1927787	hsa-miR-4419a	CLIP-seq
MIRT1927788	hsa-miR-4423-5p	CLIP-seq
MIRT1927789	hsa-miR-4430	CLIP-seq
MIRT771931	hsa-miR-4436a	CLIP-seq
MIRT1927790	hsa-miR-4446-3p	CLIP-seq
MIRT1927791	hsa-miR-4486	CLIP-seq
MIRT1927792	hsa-miR-4492	CLIP-seq
MIRT1927793	hsa-miR-4498	CLIP-seq
MIRT1927794	hsa-miR-4510	CLIP-seq
MIRT1927795	hsa-miR-4530	CLIP-seq
MIRT771940	hsa-miR-4650-5p	CLIP-seq
MIRT1927796	hsa-miR-4667-5p	CLIP-seq
MIRT1927797	hsa-miR-4700-5p	CLIP-seq
MIRT771943	hsa-miR-4717-3p	CLIP-seq
MIRT1927798	hsa-miR-4721	CLIP-seq
MIRT1927799	hsa-miR-4725-3p	CLIP-seq
MIRT1927800	hsa-miR-4731-5p	CLIP-seq
MIRT771949	hsa-miR-4739	CLIP-seq
MIRT771951	hsa-miR-4745-3p	CLIP-seq
MIRT771953	hsa-miR-4756-5p	CLIP-seq
MIRT1927801	hsa-miR-4793-5p	CLIP-seq
MIRT1927802	hsa-miR-548p	CLIP-seq
MIRT1927803	hsa-miR-552	CLIP-seq
MIRT771969	hsa-miR-555	CLIP-seq
MIRT1927804	hsa-miR-603	CLIP-seq
MIRT1927805	hsa-miR-762	CLIP-seq
MIRT771869	hsa-miR-106a	CLIP-seq
MIRT771870	hsa-miR-106b	CLIP-seq
MIRT2168680	hsa-miR-1207-5p	CLIP-seq
MIRT771877	hsa-miR-1254	CLIP-seq
MIRT771881	hsa-miR-1273e	CLIP-seq
MIRT2168681	hsa-miR-1293	CLIP-seq
MIRT771883	hsa-miR-1343	CLIP-seq
MIRT771886	hsa-miR-1537	CLIP-seq
MIRT771887	hsa-miR-1538	CLIP-seq
MIRT771888	hsa-miR-17	CLIP-seq
MIRT771891	hsa-miR-20a	CLIP-seq
MIRT771892	hsa-miR-20b	CLIP-seq
MIRT771893	hsa-miR-2278	CLIP-seq
MIRT771896	hsa-miR-302a	CLIP-seq
MIRT771897	hsa-miR-302b	CLIP-seq
MIRT771898	hsa-miR-302c	CLIP-seq
MIRT771899	hsa-miR-302d	CLIP-seq
MIRT771900	hsa-miR-302e	CLIP-seq
MIRT771901	hsa-miR-3074-5p	CLIP-seq
MIRT771902	hsa-miR-3116	CLIP-seq
MIRT771904	hsa-miR-3129-3p	CLIP-seq
MIRT2168682	hsa-miR-3183	CLIP-seq
MIRT771910	hsa-miR-3192	CLIP-seq
MIRT771913	hsa-miR-3609	CLIP-seq
MIRT771917	hsa-miR-3650	CLIP-seq
MIRT2168683	hsa-miR-3661	CLIP-seq
MIRT771920	hsa-miR-3714	CLIP-seq
MIRT771921	hsa-miR-372	CLIP-seq
MIRT771922	hsa-miR-373	CLIP-seq
MIRT771923	hsa-miR-378g	CLIP-seq
MIRT771925	hsa-miR-3924	CLIP-seq
MIRT2168684	hsa-miR-3929	CLIP-seq
MIRT2168685	hsa-miR-4274	CLIP-seq
MIRT771929	hsa-miR-4300	CLIP-seq
MIRT771930	hsa-miR-4314	CLIP-seq
MIRT2168686	hsa-miR-4419b	CLIP-seq
MIRT2168687	hsa-miR-4434	CLIP-seq
MIRT2168688	hsa-miR-4447	CLIP-seq
MIRT771932	hsa-miR-4455	CLIP-seq
MIRT2168689	hsa-miR-4472	CLIP-seq
MIRT2168690	hsa-miR-4478	CLIP-seq
MIRT2168691	hsa-miR-4483	CLIP-seq
MIRT771933	hsa-miR-4505	CLIP-seq
MIRT2168692	hsa-miR-4516	CLIP-seq
MIRT1927795	hsa-miR-4530	CLIP-seq
MIRT771937	hsa-miR-4643	CLIP-seq
MIRT771938	hsa-miR-4646-5p	CLIP-seq
MIRT771941	hsa-miR-4683	CLIP-seq
MIRT2168693	hsa-miR-4690-3p	CLIP-seq
MIRT771943	hsa-miR-4717-3p	CLIP-seq
MIRT771944	hsa-miR-4722-3p	CLIP-seq
MIRT2168694	hsa-miR-4723-3p	CLIP-seq
MIRT771951	hsa-miR-4745-3p	CLIP-seq
MIRT2168695	hsa-miR-4763-3p	CLIP-seq
MIRT771956	hsa-miR-4796-3p	CLIP-seq
MIRT771957	hsa-miR-483-3p	CLIP-seq
MIRT2168696	hsa-miR-485-5p	CLIP-seq
MIRT771959	hsa-miR-516a-3p	CLIP-seq
MIRT771960	hsa-miR-519d	CLIP-seq
MIRT771961	hsa-miR-520a-3p	CLIP-seq
MIRT771962	hsa-miR-520b	CLIP-seq
MIRT771963	hsa-miR-520c-3p	CLIP-seq
MIRT771964	hsa-miR-520d-3p	CLIP-seq
MIRT771965	hsa-miR-520e	CLIP-seq
MIRT771966	hsa-miR-520f	CLIP-seq
MIRT771967	hsa-miR-548ah	CLIP-seq
MIRT2168697	hsa-miR-550b	CLIP-seq
MIRT771969	hsa-miR-555	CLIP-seq
MIRT771971	hsa-miR-609	CLIP-seq
MIRT2168698	hsa-miR-622	CLIP-seq
MIRT2168699	hsa-miR-631	CLIP-seq
MIRT771973	hsa-miR-636	CLIP-seq
MIRT771975	hsa-miR-661	CLIP-seq
MIRT771976	hsa-miR-920	CLIP-seq
MIRT771977	hsa-miR-93	CLIP-seq
MIRT771978	hsa-miR-940	CLIP-seq
MIRT1927800	hsa-miR-4731-5p	CLIP-seq
MIRT2168697	hsa-miR-550b	CLIP-seq
MIRT2383999	hsa-miR-625	CLIP-seq
MIRT771903	hsa-miR-3120-5p	CLIP-seq
MIRT2443333	hsa-miR-4640-3p	CLIP-seq
MIRT2443334	hsa-miR-4732-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001675	Process	Acrosome assembly	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0007289	Process	Spermatid nucleus differentiation	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604019
• HGNC: 5177
• e!Ensembl: ENSG00000106351

Protein

• UniProt ID: O95081
• Protein name: Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	32 → 148	Putative GTPase activating protein for Arf	Domain

• Sequence:

  MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
  TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
  LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
  DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
  PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
  GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
  FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
  LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
  L

• Sequence length: 481

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Achalasia Addisonianism Alacrimia syndrome	Associate	37331934	★☆☆☆☆ Found in Text Mining only
Acute Febrile Encephalopathy	Associate	31178128	★☆☆☆☆ Found in Text Mining only
Anaplasia	Associate	30036517	★☆☆☆☆ Found in Text Mining only
Endometriosis	Associate	31256999	★☆☆☆☆ Found in Text Mining only
Familial Glucocorticoid Deficiency 1	Associate	37331934	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Associate	34494102	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	10908574, 9050861	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	10830185	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	22074739	★☆☆☆☆ Found in Text Mining only
Pena Shokeir syndrome type 1	Associate	33168876	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Associate	30036517	★☆☆☆☆ Found in Text Mining only