Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3215
Gene name Gene Name - the full gene name approved by the HGNC.	Homeobox B5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HOXB5
Synonyms (NCBI Gene) Gene synonyms aliases	HHO.C10, HOX2, HOX2A, HU-1, Hox2.1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcriptio

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001971	hsa-miR-221-3p	Gluc assay	18794255
MIRT006902	hsa-miR-7-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22768238
MIRT016641	hsa-miR-429	Reporter assay	20005803
MIRT020354	hsa-miR-200a-3p	Reporter assay	20005803
MIRT021075	hsa-miR-200c-3p	Reporter assay	20005803
MIRT021658	hsa-miR-141-3p	Reporter assay	20005803
MIRT024129	hsa-miR-200b-3p	Reporter assay	20005803
MIRT657301	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT657300	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT657299	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT657298	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657297	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT657296	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT657295	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT657294	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT657293	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657292	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT657291	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT657290	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT657289	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT657288	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT657287	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT657286	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT491458	hsa-miR-4779	PAR-CLIP	23592263
MIRT491457	hsa-miR-1321	PAR-CLIP	23592263
MIRT491456	hsa-miR-4739	PAR-CLIP	23592263
MIRT491454	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT491455	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT491453	hsa-miR-4784	PAR-CLIP	23592263
MIRT491452	hsa-miR-4419a	PAR-CLIP	23592263
MIRT491451	hsa-miR-4510	PAR-CLIP	23592263
MIRT491450	hsa-miR-6127	PAR-CLIP	23592263
MIRT491449	hsa-miR-6129	PAR-CLIP	23592263
MIRT491448	hsa-miR-6130	PAR-CLIP	23592263
MIRT491447	hsa-miR-6133	PAR-CLIP	23592263
MIRT491446	hsa-miR-765	PAR-CLIP	23592263
MIRT491445	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT491444	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT491443	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT491442	hsa-miR-4689	PAR-CLIP	23592263
MIRT491441	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT657301	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT657300	hsa-miR-1285-5p	HITS-CLIP	23824327
MIRT657299	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT657298	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT657297	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT657296	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT657295	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT657294	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT657293	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657292	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT657291	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT657290	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT657289	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT657288	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT657287	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT657286	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT616105	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT616104	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT616103	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT616102	hsa-miR-637	HITS-CLIP	23824327
MIRT616101	hsa-miR-625-5p	HITS-CLIP	23824327
MIRT616100	hsa-miR-4723-5p	HITS-CLIP	23824327
MIRT616099	hsa-miR-5698	HITS-CLIP	23824327
MIRT616098	hsa-miR-6870-5p	HITS-CLIP	23824327
MIRT616097	hsa-miR-7111-5p	HITS-CLIP	23824327
MIRT616096	hsa-miR-4525	HITS-CLIP	23824327
MIRT616095	hsa-miR-5010-5p	HITS-CLIP	23824327
MIRT616094	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT616093	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616092	hsa-miR-1275	HITS-CLIP	23824327
MIRT616091	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT616090	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT616089	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT491458	hsa-miR-4779	PAR-CLIP	23592263
MIRT491457	hsa-miR-1321	PAR-CLIP	23592263
MIRT491456	hsa-miR-4739	PAR-CLIP	23592263
MIRT491454	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT491455	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT491453	hsa-miR-4784	PAR-CLIP	23592263
MIRT491452	hsa-miR-4419a	PAR-CLIP	23592263
MIRT491451	hsa-miR-4510	PAR-CLIP	23592263
MIRT491450	hsa-miR-6127	PAR-CLIP	23592263
MIRT491449	hsa-miR-6129	PAR-CLIP	23592263
MIRT491448	hsa-miR-6130	PAR-CLIP	23592263
MIRT491447	hsa-miR-6133	PAR-CLIP	23592263
MIRT491446	hsa-miR-765	PAR-CLIP	23592263
MIRT491445	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT491444	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT491443	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT491442	hsa-miR-4689	PAR-CLIP	23592263
MIRT491441	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT1053358	hsa-miR-1343	CLIP-seq
MIRT1053359	hsa-miR-141	CLIP-seq
MIRT1053360	hsa-miR-181a	CLIP-seq
MIRT1053361	hsa-miR-181b	CLIP-seq
MIRT1053362	hsa-miR-181c	CLIP-seq
MIRT1053363	hsa-miR-181d	CLIP-seq
MIRT1053364	hsa-miR-200a	CLIP-seq
MIRT1053365	hsa-miR-3153	CLIP-seq
MIRT1053366	hsa-miR-4262	CLIP-seq
MIRT1053367	hsa-miR-4730	CLIP-seq
MIRT1053368	hsa-miR-543	CLIP-seq
MIRT1053369	hsa-miR-625	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	3000607
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0045446	Process	Endothelial cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142960	5116	ENSG00000120075

Protein

UniProt ID

P09067

Protein name

Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	195 → 251	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Spinal cord.

Sequence

MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSS
ASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGDSHGAKPSASSPSDQ
ATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWM
RKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKI
WFQNRRMKWKKDNKLKSMSLATAGSAFQP

Sequence length

269

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Obesity	Obesity	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Barrett Esophagus	Stimulate	22603795
Breast Neoplasms	Associate	25999793
Breast Neoplasms	Stimulate	30115380
Carcinoma Basal Cell	Associate	32382535
Carcinoma Non Small Cell Lung	Associate	37304647
Carcinoma Small Cell	Associate	33664492
Ependymoma	Stimulate	14578171
Glioma	Associate	35044082
Hirschsprung Disease	Associate	22648184
Leukemia	Associate	1372255
Mullerian aplasia	Associate	24608967
Neoplasm Metastasis	Associate	25999793
Neoplasms	Associate	17623056, 21552713, 22768238, 30115380, 37304647
Ovarian Neoplasms	Associate	17623056
Prostatic Neoplasms	Associate	30286759
Squamous Cell Carcinoma of Head and Neck	Associate	21552713, 32319550
Teratocarcinoma	Associate	1675427
Urinary Bladder Neoplasms	Associate	22768238, 30170380

HOXB5 (homeobox B5)