TAAR6 (trace amine associated receptor 6)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
319100
Gene name Gene Name - the full gene name approved by the HGNC.
Trace amine associated receptor 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAAR6
Synonyms (NCBI Gene) Gene synonyms aliases
TA4, TAR4, TAR6, TRAR4, taR-4, taR-6
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT025149 hsa-miR-181a-5p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0001594 Function Trace-amine receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity TAS 15718104
GO:0005886 Component Plasma membrane IEA
GO:0007186 Process G protein-coupled receptor signaling pathway IEA
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608923 20978 ENSG00000146383
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96RI8
Protein name Trace amine-associated receptor 6 (TaR-6) (Trace amine receptor 6) (Trace amine receptor 4) (TaR-4)
Protein function Olfactory receptor specific for trace amines, such as beta-phenylethylamine (beta-PEA). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific i
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 49 → 311 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta (PubMed:15329799). In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra,
Sequence
Sequence length 345
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction   Amine ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Mental depression Depressive disorder 20493543 ClinVar
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (8)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Squamous Cell Associate 3147275
Glomerulonephritis IGA Stimulate 2575472
Inflammation Associate 35053262
Melanoma Inhibit 35053262
Multiple Myeloma Inhibit 2575472
Neoplasms Associate 3147275
Neoplasms Squamous Cell Associate 2184880
Schizophrenia Associate 15329799