Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	319
Gene name Gene Name - the full gene name approved by the HGNC.	Apolipoprotein F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	APOF
Synonyms (NCBI Gene) Gene synonyms aliases	Apo-F, LTIP
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030053	hsa-miR-26b-5p	Microarray	19088304
MIRT043031	hsa-miR-324-5p	CLASH	23622248
MIRT790054	hsa-miR-1184	CLIP-seq
MIRT790055	hsa-miR-125a-3p	CLIP-seq
MIRT790056	hsa-miR-1307	CLIP-seq
MIRT790057	hsa-miR-3934	CLIP-seq
MIRT790058	hsa-miR-4258	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT790060	hsa-miR-4638-5p	CLIP-seq
MIRT790061	hsa-miR-4680-5p	CLIP-seq
MIRT790062	hsa-miR-5095	CLIP-seq
MIRT790063	hsa-miR-513a-3p	CLIP-seq
MIRT790064	hsa-miR-639	CLIP-seq
MIRT790065	hsa-miR-720	CLIP-seq
MIRT790066	hsa-miR-764	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT1933054	hsa-miR-1915	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT1933059	hsa-miR-4726-3p	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT790054	hsa-miR-1184	CLIP-seq
MIRT790055	hsa-miR-125a-3p	CLIP-seq
MIRT2173231	hsa-miR-129-5p	CLIP-seq
MIRT790056	hsa-miR-1307	CLIP-seq
MIRT1933054	hsa-miR-1915	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT2173232	hsa-miR-24	CLIP-seq
MIRT2173233	hsa-miR-3155	CLIP-seq
MIRT2173234	hsa-miR-3155b	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT2173235	hsa-miR-3672	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT790057	hsa-miR-3934	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT790060	hsa-miR-4638-5p	CLIP-seq
MIRT2173236	hsa-miR-4713-5p	CLIP-seq
MIRT1933059	hsa-miR-4726-3p	CLIP-seq
MIRT2173237	hsa-miR-484	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT790064	hsa-miR-639	CLIP-seq
MIRT790065	hsa-miR-720	CLIP-seq
MIRT790066	hsa-miR-764	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT2384325	hsa-miR-4794	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	TAS	8093033
GO:0005319	Function	Lipid transporter activity	TAS	6816269
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	28935895
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	8093033
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006869	Process	Lipid transport	TAS	6816269
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IBA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	TAS	6816269
GO:0015485	Function	Cholesterol binding	TAS	6816269
GO:0033344	Process	Cholesterol efflux	IEA
GO:0034362	Component	Low-density lipoprotein particle	IEA
GO:0034364	Component	High-density lipoprotein particle	IEA

MIM	HGNC	e!Ensembl
107760	615	ENSG00000175336

Protein

UniProt ID

Q13790

Protein name

Apolipoprotein F (Apo-F) (Lipid transfer inhibitor protein) (LTIP)

Protein function

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. {ECO:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15148	Apolipo_F	62 → 260	Apolipoprotein F	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. {ECO:0000269|PubMed:8093033}.

Sequence

MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTNVLMHFPLSLESQTPSS
DPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNAT
QVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTGRVGRSLPTEDCENEKEQAVH
NVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLA
ISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEV
VSSAPYWGWAIIKSYDLDPGAGSLEI

Sequence length

326

Interactions

View interactions

	Reactome
			LDL remodeling

APOF (apolipoprotein F)