Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3174
Gene name Gene Name - the full gene name approved by the HGNC.	Hepatocyte nuclear factor 4 gamma
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HNF4G
Synonyms (NCBI Gene) Gene synonyms aliases	NR2A2, NR2A3
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q21.13

Show/Hide all(56)

miRTarBase ID	miRNA	Experiments	Reference
MIRT709336	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT709335	hsa-miR-4263	HITS-CLIP	19536157
MIRT709334	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT709333	hsa-miR-3149	HITS-CLIP	19536157
MIRT709332	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT709336	hsa-miR-4799-5p	HITS-CLIP	19536157
MIRT709335	hsa-miR-4263	HITS-CLIP	19536157
MIRT709334	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT709333	hsa-miR-3149	HITS-CLIP	19536157
MIRT709332	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT1050583	hsa-miR-101	CLIP-seq
MIRT1050584	hsa-miR-1197	CLIP-seq
MIRT1050585	hsa-miR-139-5p	CLIP-seq
MIRT1050586	hsa-miR-140-5p	CLIP-seq
MIRT1050587	hsa-miR-144	CLIP-seq
MIRT1050588	hsa-miR-3121-3p	CLIP-seq
MIRT1050589	hsa-miR-3646	CLIP-seq
MIRT1050590	hsa-miR-3924	CLIP-seq
MIRT1050591	hsa-miR-410	CLIP-seq
MIRT1050592	hsa-miR-4272	CLIP-seq
MIRT1050593	hsa-miR-4738-3p	CLIP-seq
MIRT1050594	hsa-miR-4796-3p	CLIP-seq
MIRT1050595	hsa-miR-485-3p	CLIP-seq
MIRT1050596	hsa-miR-498	CLIP-seq
MIRT1050597	hsa-miR-513a-3p	CLIP-seq
MIRT1050598	hsa-miR-548v	CLIP-seq
MIRT1050599	hsa-miR-568	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT1920479	hsa-miR-3120-3p	CLIP-seq
MIRT1920480	hsa-miR-596	CLIP-seq
MIRT2243779	hsa-miR-1224-3p	CLIP-seq
MIRT2243780	hsa-miR-1260	CLIP-seq
MIRT2243781	hsa-miR-1260b	CLIP-seq
MIRT2243782	hsa-miR-1269	CLIP-seq
MIRT2243783	hsa-miR-1269b	CLIP-seq
MIRT2243784	hsa-miR-128	CLIP-seq
MIRT2243785	hsa-miR-1280	CLIP-seq
MIRT2243786	hsa-miR-188-3p	CLIP-seq
MIRT2243787	hsa-miR-188-5p	CLIP-seq
MIRT2243788	hsa-miR-27a	CLIP-seq
MIRT2243789	hsa-miR-27b	CLIP-seq
MIRT2243790	hsa-miR-3156-3p	CLIP-seq
MIRT2243791	hsa-miR-4279	CLIP-seq
MIRT2243792	hsa-miR-432	CLIP-seq
MIRT2243793	hsa-miR-4446-5p	CLIP-seq
MIRT2243794	hsa-miR-4529-3p	CLIP-seq
MIRT2243795	hsa-miR-4755-5p	CLIP-seq
MIRT2243796	hsa-miR-617	CLIP-seq
MIRT2243797	hsa-miR-642a	CLIP-seq
MIRT2389077	hsa-miR-1208	CLIP-seq
MIRT2389078	hsa-miR-2909	CLIP-seq
MIRT2389079	hsa-miR-452	CLIP-seq
MIRT2389080	hsa-miR-4676-3p	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12220531
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	23896584
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8622695
GO:0004879	Function	Nuclear receptor activity	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	23896584
GO:0048856	Process	Anatomical structure development	IBA	21873635
GO:0072686	Component	Mitotic spindle	IDA

MIM	HGNC	e!Ensembl
605966	5026	ENSG00000164749

Protein

UniProt ID

Q14541

Protein name

Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)

Protein function

Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

PDB

1LV2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00105	zf-C4	10 → 79	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	124 → 312	Ligand-binding domain of nuclear hormone receptor	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Sequence

MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK
RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS
SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL
LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL
KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW
QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS
TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL

Sequence length

408

Interactions

View interactions

	KEGG		Reactome
	Maturity onset diabetes of the young		Nuclear Receptor transcription pathway

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	23535729
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	25751625, 29059683, 23535729

Show/Hide Unknown Diseases (7)

Disease term	Disease name	Source
Unknown
Obesity	Obesity	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS
Gout	Gout	GWAS
Hypertension	Hypertension	GWAS
Oligodendroglioma	Oligodendroglioma	GWAS
Insomnia	Insomnia	GWAS
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	36923501
Carcinoma Hepatocellular	Associate	20976847
Carcinoma Squamous Cell	Associate	30896821
Cognition Disorders	Associate	29907492
Colorectal Neoplasms	Associate	30896821
Developmental Disabilities	Associate	22523087
Gout	Associate	28252667
Hyperuricemia	Associate	28460474
Intestinal Diseases	Associate	25800782
Juvenile gout	Associate	28460474
Obesity	Associate	23563607, 29976977
Ovarian Neoplasms	Associate	39341888
Pancreatic Neoplasms	Associate	26854454
Schizophrenia	Associate	29907492
Urinary Bladder Neoplasms	Associate	25878394

HNF4G (hepatocyte nuclear factor 4 gamma)