Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	317
Gene name	Apoptotic peptidase activating factor 1
Gene symbol	APAF1
Synonyms (NCBI Gene)	APAF-1CED4
Chromosome	12
Chromosome location	12q23.1
Summary	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	18829576
MIRT018166	hsa-miR-335-5p	Microarray	18185580
MIRT020853	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT002410	hsa-miR-21-5p	Microarray	18591254
MIRT053424	hsa-miR-624-3p	Microarray	23807165
MIRT054353	hsa-miR-221-3p	Luciferase reporter assayQRTPCRWestern blot	23630541
MIRT054514	hsa-miR-23a-3p	Luciferase reporter assayWetsern blot	24952592
MIRT705610	hsa-miR-302f	HITS-CLIP	23313552
MIRT457990	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT457991	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT457989	hsa-miR-940	HITS-CLIP	23313552
MIRT705609	hsa-miR-3929	HITS-CLIP	23313552
MIRT705608	hsa-miR-4419b	HITS-CLIP	23313552
MIRT705607	hsa-miR-4478	HITS-CLIP	23313552
MIRT705606	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT705605	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT705604	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT705603	hsa-miR-5690	HITS-CLIP	23313552
MIRT705602	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT705601	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT457984	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT705600	hsa-miR-20b-3p	HITS-CLIP	23313552
MIRT705599	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT457982	hsa-miR-1827	HITS-CLIP	23313552
MIRT457981	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT705598	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT705597	hsa-miR-933	HITS-CLIP	23313552
MIRT705596	hsa-miR-7977	HITS-CLIP	23313552
MIRT705595	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT457979	hsa-miR-1273e	HITS-CLIP	23313552
MIRT457986	hsa-miR-665	HITS-CLIP	23313552
MIRT673437	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT673436	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT673435	hsa-miR-3622a-5p	HITS-CLIP	23824327
MIRT673434	hsa-miR-4269	HITS-CLIP	23824327
MIRT673433	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT673432	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT673431	hsa-miR-4673	HITS-CLIP	23824327
MIRT673430	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT673429	hsa-miR-3179	HITS-CLIP	23824327
MIRT673428	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT673427	hsa-miR-564	HITS-CLIP	23824327
MIRT673426	hsa-miR-4284	HITS-CLIP	23824327
MIRT673425	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673424	hsa-miR-2861	HITS-CLIP	23824327
MIRT673423	hsa-miR-4435	HITS-CLIP	23824327
MIRT457990	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT457991	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT457989	hsa-miR-940	PAR-CLIP	23592263
MIRT457988	hsa-miR-4459	PAR-CLIP	23592263
MIRT457987	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT457986	hsa-miR-665	PAR-CLIP	23592263
MIRT457985	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT457984	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT457983	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT457982	hsa-miR-1827	PAR-CLIP	23592263
MIRT457981	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT457980	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT457978	hsa-miR-4294	PAR-CLIP	23592263
MIRT457979	hsa-miR-1273e	PAR-CLIP	23592263
MIRT054353	hsa-miR-221-3p	Western blotImmunohistochemistryLuciferase reporter assay	25586265
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT002410	hsa-miR-21-5p	Luciferase reporter assayqRT-PCRWestern blot	27021436
MIRT736040	hsa-miR-27a-3p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	31452277
MIRT705610	hsa-miR-302f	HITS-CLIP	23313552
MIRT457990	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT457991	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT457989	hsa-miR-940	HITS-CLIP	23313552
MIRT705609	hsa-miR-3929	HITS-CLIP	23313552
MIRT705608	hsa-miR-4419b	HITS-CLIP	23313552
MIRT705607	hsa-miR-4478	HITS-CLIP	23313552
MIRT705606	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT705605	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT705604	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT705603	hsa-miR-5690	HITS-CLIP	23313552
MIRT705602	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT705601	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT457984	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT705600	hsa-miR-20b-3p	HITS-CLIP	23313552
MIRT705599	hsa-miR-219b-3p	HITS-CLIP	23313552
MIRT457982	hsa-miR-1827	HITS-CLIP	23313552
MIRT457981	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT705598	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT705597	hsa-miR-933	HITS-CLIP	23313552
MIRT705596	hsa-miR-7977	HITS-CLIP	23313552
MIRT705595	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT457979	hsa-miR-1273e	HITS-CLIP	23313552
MIRT457986	hsa-miR-665	HITS-CLIP	23313552
MIRT673437	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT673436	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT673435	hsa-miR-3622a-5p	HITS-CLIP	23824327
MIRT673434	hsa-miR-4269	HITS-CLIP	23824327
MIRT673433	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT673432	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT673431	hsa-miR-4673	HITS-CLIP	23824327
MIRT673430	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT673429	hsa-miR-3179	HITS-CLIP	23824327
MIRT673428	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT673427	hsa-miR-564	HITS-CLIP	23824327
MIRT673426	hsa-miR-4284	HITS-CLIP	23824327
MIRT673425	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673424	hsa-miR-2861	HITS-CLIP	23824327
MIRT673423	hsa-miR-4435	HITS-CLIP	23824327
MIRT457990	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT457991	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT457989	hsa-miR-940	PAR-CLIP	23592263
MIRT457988	hsa-miR-4459	PAR-CLIP	23592263
MIRT457987	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT457986	hsa-miR-665	PAR-CLIP	23592263
MIRT457985	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT457984	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT457983	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT457982	hsa-miR-1827	PAR-CLIP	23592263
MIRT457981	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT457980	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT457978	hsa-miR-4294	PAR-CLIP	23592263
MIRT457979	hsa-miR-1273e	PAR-CLIP	23592263
MIRT788589	hsa-miR-2054	CLIP-seq
MIRT788590	hsa-miR-216a	CLIP-seq
MIRT788591	hsa-miR-216b	CLIP-seq
MIRT788592	hsa-miR-24	CLIP-seq
MIRT788593	hsa-miR-3065-3p	CLIP-seq
MIRT788594	hsa-miR-3122	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT788597	hsa-miR-3913-5p	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT788599	hsa-miR-1228	CLIP-seq
MIRT788600	hsa-miR-1255a	CLIP-seq
MIRT788601	hsa-miR-1255b	CLIP-seq
MIRT788602	hsa-miR-1262	CLIP-seq
MIRT788603	hsa-miR-1273g	CLIP-seq
MIRT788604	hsa-miR-1304	CLIP-seq
MIRT788605	hsa-miR-130a	CLIP-seq
MIRT788606	hsa-miR-130b	CLIP-seq
MIRT788607	hsa-miR-132	CLIP-seq
MIRT788608	hsa-miR-200b	CLIP-seq
MIRT788609	hsa-miR-200c	CLIP-seq
MIRT788589	hsa-miR-2054	CLIP-seq
MIRT788610	hsa-miR-2114	CLIP-seq
MIRT788611	hsa-miR-212	CLIP-seq
MIRT788590	hsa-miR-216a	CLIP-seq
MIRT788591	hsa-miR-216b	CLIP-seq
MIRT788612	hsa-miR-217	CLIP-seq
MIRT788613	hsa-miR-2964a-3p	CLIP-seq
MIRT788614	hsa-miR-301a	CLIP-seq
MIRT788615	hsa-miR-301b	CLIP-seq
MIRT788593	hsa-miR-3065-3p	CLIP-seq
MIRT788616	hsa-miR-3065-5p	CLIP-seq
MIRT788617	hsa-miR-3119	CLIP-seq
MIRT788594	hsa-miR-3122	CLIP-seq
MIRT788618	hsa-miR-3128	CLIP-seq
MIRT788619	hsa-miR-3153	CLIP-seq
MIRT788620	hsa-miR-3159	CLIP-seq
MIRT788621	hsa-miR-3170	CLIP-seq
MIRT788622	hsa-miR-3189-3p	CLIP-seq
MIRT788623	hsa-miR-330-3p	CLIP-seq
MIRT788624	hsa-miR-3605-5p	CLIP-seq
MIRT788625	hsa-miR-3612	CLIP-seq
MIRT788626	hsa-miR-3613-3p	CLIP-seq
MIRT788627	hsa-miR-3666	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT788597	hsa-miR-3913-5p	CLIP-seq
MIRT788628	hsa-miR-3919	CLIP-seq
MIRT788629	hsa-miR-3942-3p	CLIP-seq
MIRT788630	hsa-miR-4252	CLIP-seq
MIRT788631	hsa-miR-4266	CLIP-seq
MIRT788632	hsa-miR-429	CLIP-seq
MIRT788633	hsa-miR-4295	CLIP-seq
MIRT788634	hsa-miR-4418	CLIP-seq
MIRT788635	hsa-miR-4474-5p	CLIP-seq
MIRT788636	hsa-miR-454	CLIP-seq
MIRT788637	hsa-miR-4640-3p	CLIP-seq
MIRT788638	hsa-miR-4671-3p	CLIP-seq
MIRT788639	hsa-miR-4695-5p	CLIP-seq
MIRT788640	hsa-miR-4697-3p	CLIP-seq
MIRT788641	hsa-miR-4701-3p	CLIP-seq
MIRT788642	hsa-miR-4712-3p	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT788643	hsa-miR-4756-3p	CLIP-seq
MIRT788644	hsa-miR-4760-5p	CLIP-seq
MIRT788645	hsa-miR-4793-3p	CLIP-seq
MIRT788646	hsa-miR-485-5p	CLIP-seq
MIRT788647	hsa-miR-508-5p	CLIP-seq
MIRT788648	hsa-miR-509-3-5p	CLIP-seq
MIRT788649	hsa-miR-509-5p	CLIP-seq
MIRT788650	hsa-miR-518a-5p	CLIP-seq
MIRT788651	hsa-miR-527	CLIP-seq
MIRT788652	hsa-miR-548ac	CLIP-seq
MIRT788653	hsa-miR-548ae	CLIP-seq
MIRT788654	hsa-miR-548aj	CLIP-seq
MIRT788655	hsa-miR-548am	CLIP-seq
MIRT788656	hsa-miR-548d-3p	CLIP-seq
MIRT788657	hsa-miR-548x	CLIP-seq
MIRT788658	hsa-miR-548z	CLIP-seq
MIRT788659	hsa-miR-555	CLIP-seq
MIRT788660	hsa-miR-595	CLIP-seq
MIRT788661	hsa-miR-650	CLIP-seq
MIRT788662	hsa-miR-651	CLIP-seq
MIRT788663	hsa-miR-661	CLIP-seq
MIRT788664	hsa-miR-766	CLIP-seq
MIRT788665	hsa-miR-885-3p	CLIP-seq
MIRT788666	hsa-miR-890	CLIP-seq
MIRT788667	hsa-miR-1276	CLIP-seq
MIRT788668	hsa-miR-128	CLIP-seq
MIRT788605	hsa-miR-130a	CLIP-seq
MIRT788606	hsa-miR-130b	CLIP-seq
MIRT788607	hsa-miR-132	CLIP-seq
MIRT788669	hsa-miR-145	CLIP-seq
MIRT788670	hsa-miR-19a	CLIP-seq
MIRT788671	hsa-miR-19b	CLIP-seq
MIRT788611	hsa-miR-212	CLIP-seq
MIRT788672	hsa-miR-2467-5p	CLIP-seq
MIRT788673	hsa-miR-27a	CLIP-seq
MIRT788674	hsa-miR-27b	CLIP-seq
MIRT788614	hsa-miR-301a	CLIP-seq
MIRT788615	hsa-miR-301b	CLIP-seq
MIRT788675	hsa-miR-30a	CLIP-seq
MIRT788676	hsa-miR-30b	CLIP-seq
MIRT788677	hsa-miR-30c	CLIP-seq
MIRT788678	hsa-miR-30d	CLIP-seq
MIRT788679	hsa-miR-30e	CLIP-seq
MIRT788680	hsa-miR-3188	CLIP-seq
MIRT788681	hsa-miR-3607-3p	CLIP-seq
MIRT788626	hsa-miR-3613-3p	CLIP-seq
MIRT788627	hsa-miR-3666	CLIP-seq
MIRT788682	hsa-miR-3975	CLIP-seq
MIRT788633	hsa-miR-4295	CLIP-seq
MIRT788683	hsa-miR-4311	CLIP-seq
MIRT788684	hsa-miR-4422	CLIP-seq
MIRT788685	hsa-miR-4433	CLIP-seq
MIRT788636	hsa-miR-454	CLIP-seq
MIRT788686	hsa-miR-4661-5p	CLIP-seq
MIRT788687	hsa-miR-4684-5p	CLIP-seq
MIRT788646	hsa-miR-485-5p	CLIP-seq
MIRT788652	hsa-miR-548ac	CLIP-seq
MIRT788688	hsa-miR-548c-3p	CLIP-seq
MIRT788656	hsa-miR-548d-3p	CLIP-seq
MIRT788658	hsa-miR-548z	CLIP-seq
MIRT788689	hsa-miR-583	CLIP-seq
MIRT788690	hsa-miR-596	CLIP-seq
MIRT788691	hsa-miR-935	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT788646	hsa-miR-485-5p	CLIP-seq
MIRT1932574	hsa-miR-10a	CLIP-seq
MIRT1932575	hsa-miR-10b	CLIP-seq
MIRT1932576	hsa-miR-1182	CLIP-seq
MIRT1932577	hsa-miR-1225-5p	CLIP-seq
MIRT1932578	hsa-miR-136	CLIP-seq
MIRT1932579	hsa-miR-193a-5p	CLIP-seq
MIRT788610	hsa-miR-2114	CLIP-seq
MIRT788590	hsa-miR-216a	CLIP-seq
MIRT788591	hsa-miR-216b	CLIP-seq
MIRT1932580	hsa-miR-2276	CLIP-seq
MIRT1932581	hsa-miR-23a	CLIP-seq
MIRT1932582	hsa-miR-23b	CLIP-seq
MIRT1932583	hsa-miR-23c	CLIP-seq
MIRT788613	hsa-miR-2964a-3p	CLIP-seq
MIRT788593	hsa-miR-3065-3p	CLIP-seq
MIRT788616	hsa-miR-3065-5p	CLIP-seq
MIRT788594	hsa-miR-3122	CLIP-seq
MIRT788618	hsa-miR-3128	CLIP-seq
MIRT1932584	hsa-miR-3132	CLIP-seq
MIRT1932585	hsa-miR-324-5p	CLIP-seq
MIRT788623	hsa-miR-330-3p	CLIP-seq
MIRT1932586	hsa-miR-339-5p	CLIP-seq
MIRT788625	hsa-miR-3612	CLIP-seq
MIRT1932587	hsa-miR-3652	CLIP-seq
MIRT1932588	hsa-miR-3667-5p	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT1932589	hsa-miR-371-5p	CLIP-seq
MIRT1932590	hsa-miR-378	CLIP-seq
MIRT1932591	hsa-miR-378b	CLIP-seq
MIRT1932592	hsa-miR-378c	CLIP-seq
MIRT1932593	hsa-miR-378d	CLIP-seq
MIRT1932594	hsa-miR-378e	CLIP-seq
MIRT1932595	hsa-miR-378f	CLIP-seq
MIRT1932596	hsa-miR-378h	CLIP-seq
MIRT1932597	hsa-miR-378i	CLIP-seq
MIRT788597	hsa-miR-3913-5p	CLIP-seq
MIRT1932598	hsa-miR-3924	CLIP-seq
MIRT1932599	hsa-miR-422a	CLIP-seq
MIRT788630	hsa-miR-4252	CLIP-seq
MIRT1932600	hsa-miR-4263	CLIP-seq
MIRT1932601	hsa-miR-4282	CLIP-seq
MIRT1932602	hsa-miR-431	CLIP-seq
MIRT788683	hsa-miR-4311	CLIP-seq
MIRT1932603	hsa-miR-4421	CLIP-seq
MIRT1932604	hsa-miR-4430	CLIP-seq
MIRT1932605	hsa-miR-4455	CLIP-seq
MIRT788635	hsa-miR-4474-5p	CLIP-seq
MIRT1932606	hsa-miR-4521	CLIP-seq
MIRT1932607	hsa-miR-4686	CLIP-seq
MIRT788639	hsa-miR-4695-5p	CLIP-seq
MIRT1932608	hsa-miR-4720-3p	CLIP-seq
MIRT1932609	hsa-miR-4725-5p	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT1932610	hsa-miR-4733-5p	CLIP-seq
MIRT1932611	hsa-miR-4772-3p	CLIP-seq
MIRT788645	hsa-miR-4793-3p	CLIP-seq
MIRT1932612	hsa-miR-4804-3p	CLIP-seq
MIRT788646	hsa-miR-485-5p	CLIP-seq
MIRT1932613	hsa-miR-504	CLIP-seq
MIRT788647	hsa-miR-508-5p	CLIP-seq
MIRT1932614	hsa-miR-5096	CLIP-seq
MIRT1932615	hsa-miR-548g	CLIP-seq
MIRT1932616	hsa-miR-550a	CLIP-seq
MIRT1932617	hsa-miR-579	CLIP-seq
MIRT1932618	hsa-miR-630	CLIP-seq
MIRT788661	hsa-miR-650	CLIP-seq
MIRT788664	hsa-miR-766	CLIP-seq
MIRT788665	hsa-miR-885-3p	CLIP-seq
MIRT1932619	hsa-miR-885-5p	CLIP-seq
MIRT1932620	hsa-miR-888	CLIP-seq
MIRT788666	hsa-miR-890	CLIP-seq
MIRT2172881	hsa-miR-300	CLIP-seq
MIRT2172882	hsa-miR-381	CLIP-seq
MIRT2172883	hsa-miR-4659a-3p	CLIP-seq
MIRT2172884	hsa-miR-4659b-3p	CLIP-seq
MIRT788666	hsa-miR-890	CLIP-seq
MIRT788605	hsa-miR-130a	CLIP-seq
MIRT788606	hsa-miR-130b	CLIP-seq
MIRT788614	hsa-miR-301a	CLIP-seq
MIRT788615	hsa-miR-301b	CLIP-seq
MIRT788627	hsa-miR-3666	CLIP-seq
MIRT788633	hsa-miR-4295	CLIP-seq
MIRT788636	hsa-miR-454	CLIP-seq
MIRT788638	hsa-miR-4671-3p	CLIP-seq
MIRT2435424	hsa-miR-1202	CLIP-seq
MIRT2435425	hsa-miR-139-5p	CLIP-seq
MIRT2435426	hsa-miR-183	CLIP-seq
MIRT2435427	hsa-miR-198	CLIP-seq
MIRT2435428	hsa-miR-3194-5p	CLIP-seq
MIRT2435429	hsa-miR-3972	CLIP-seq
MIRT2435430	hsa-miR-4446-3p	CLIP-seq
MIRT2435431	hsa-miR-4530	CLIP-seq
MIRT2435432	hsa-miR-539	CLIP-seq
MIRT2435433	hsa-miR-548v	CLIP-seq
MIRT2435434	hsa-miR-549	CLIP-seq
MIRT2435435	hsa-miR-646	CLIP-seq
MIRT1932574	hsa-miR-10a	CLIP-seq
MIRT1932575	hsa-miR-10b	CLIP-seq
MIRT2435424	hsa-miR-1202	CLIP-seq
MIRT788667	hsa-miR-1276	CLIP-seq
MIRT2443766	hsa-miR-1283	CLIP-seq
MIRT2443767	hsa-miR-1301	CLIP-seq
MIRT788605	hsa-miR-130a	CLIP-seq
MIRT788606	hsa-miR-130b	CLIP-seq
MIRT2435425	hsa-miR-139-5p	CLIP-seq
MIRT2435426	hsa-miR-183	CLIP-seq
MIRT2435427	hsa-miR-198	CLIP-seq
MIRT788670	hsa-miR-19a	CLIP-seq
MIRT788671	hsa-miR-19b	CLIP-seq
MIRT788590	hsa-miR-216a	CLIP-seq
MIRT788591	hsa-miR-216b	CLIP-seq
MIRT788614	hsa-miR-301a	CLIP-seq
MIRT788615	hsa-miR-301b	CLIP-seq
MIRT788593	hsa-miR-3065-3p	CLIP-seq
MIRT788594	hsa-miR-3122	CLIP-seq
MIRT1932584	hsa-miR-3132	CLIP-seq
MIRT2435428	hsa-miR-3194-5p	CLIP-seq
MIRT2443768	hsa-miR-331-5p	CLIP-seq
MIRT2443769	hsa-miR-338-5p	CLIP-seq
MIRT1932586	hsa-miR-339-5p	CLIP-seq
MIRT788626	hsa-miR-3613-3p	CLIP-seq
MIRT788627	hsa-miR-3666	CLIP-seq
MIRT2443770	hsa-miR-3680	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT788597	hsa-miR-3913-5p	CLIP-seq
MIRT2435429	hsa-miR-3972	CLIP-seq
MIRT788633	hsa-miR-4295	CLIP-seq
MIRT788683	hsa-miR-4311	CLIP-seq
MIRT1932603	hsa-miR-4421	CLIP-seq
MIRT788684	hsa-miR-4422	CLIP-seq
MIRT2443771	hsa-miR-4432	CLIP-seq
MIRT2435430	hsa-miR-4446-3p	CLIP-seq
MIRT2435431	hsa-miR-4530	CLIP-seq
MIRT788636	hsa-miR-454	CLIP-seq
MIRT2443772	hsa-miR-4659a-5p	CLIP-seq
MIRT2443773	hsa-miR-4659b-5p	CLIP-seq
MIRT2443774	hsa-miR-4660	CLIP-seq
MIRT2443775	hsa-miR-4678	CLIP-seq
MIRT788687	hsa-miR-4684-5p	CLIP-seq
MIRT1932609	hsa-miR-4725-5p	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT2443776	hsa-miR-4786-5p	CLIP-seq
MIRT2443777	hsa-miR-487a	CLIP-seq
MIRT1932613	hsa-miR-504	CLIP-seq
MIRT2443778	hsa-miR-5047	CLIP-seq
MIRT788652	hsa-miR-548ac	CLIP-seq
MIRT788688	hsa-miR-548c-3p	CLIP-seq
MIRT788656	hsa-miR-548d-3p	CLIP-seq
MIRT2435433	hsa-miR-548v	CLIP-seq
MIRT788658	hsa-miR-548z	CLIP-seq
MIRT2435434	hsa-miR-549	CLIP-seq
MIRT788689	hsa-miR-583	CLIP-seq
MIRT2443779	hsa-miR-593	CLIP-seq
MIRT2443780	hsa-miR-605	CLIP-seq
MIRT2435435	hsa-miR-646	CLIP-seq
MIRT2443781	hsa-miR-769-5p	CLIP-seq
MIRT1932574	hsa-miR-10a	CLIP-seq
MIRT1932575	hsa-miR-10b	CLIP-seq
MIRT2435424	hsa-miR-1202	CLIP-seq
MIRT788602	hsa-miR-1262	CLIP-seq
MIRT2443766	hsa-miR-1283	CLIP-seq
MIRT788605	hsa-miR-130a	CLIP-seq
MIRT788606	hsa-miR-130b	CLIP-seq
MIRT2435425	hsa-miR-139-5p	CLIP-seq
MIRT2476037	hsa-miR-149	CLIP-seq
MIRT2435426	hsa-miR-183	CLIP-seq
MIRT2435427	hsa-miR-198	CLIP-seq
MIRT2476038	hsa-miR-208a	CLIP-seq
MIRT2476039	hsa-miR-208b	CLIP-seq
MIRT788590	hsa-miR-216a	CLIP-seq
MIRT788591	hsa-miR-216b	CLIP-seq
MIRT1932580	hsa-miR-2276	CLIP-seq
MIRT2172881	hsa-miR-300	CLIP-seq
MIRT788614	hsa-miR-301a	CLIP-seq
MIRT788615	hsa-miR-301b	CLIP-seq
MIRT788593	hsa-miR-3065-3p	CLIP-seq
MIRT788594	hsa-miR-3122	CLIP-seq
MIRT2476040	hsa-miR-3124-3p	CLIP-seq
MIRT1932584	hsa-miR-3132	CLIP-seq
MIRT2476041	hsa-miR-3133	CLIP-seq
MIRT2476042	hsa-miR-3163	CLIP-seq
MIRT2435428	hsa-miR-3194-5p	CLIP-seq
MIRT1932586	hsa-miR-339-5p	CLIP-seq
MIRT2476043	hsa-miR-3529	CLIP-seq
MIRT2476044	hsa-miR-3617	CLIP-seq
MIRT2476045	hsa-miR-3658	CLIP-seq
MIRT788627	hsa-miR-3666	CLIP-seq
MIRT2476046	hsa-miR-3682-5p	CLIP-seq
MIRT788595	hsa-miR-3689a-3p	CLIP-seq
MIRT788596	hsa-miR-3689c	CLIP-seq
MIRT2476047	hsa-miR-379	CLIP-seq
MIRT2172882	hsa-miR-381	CLIP-seq
MIRT788597	hsa-miR-3913-5p	CLIP-seq
MIRT2435429	hsa-miR-3972	CLIP-seq
MIRT788630	hsa-miR-4252	CLIP-seq
MIRT788633	hsa-miR-4295	CLIP-seq
MIRT1932603	hsa-miR-4421	CLIP-seq
MIRT2476048	hsa-miR-4437	CLIP-seq
MIRT2435430	hsa-miR-4446-3p	CLIP-seq
MIRT2476049	hsa-miR-4511	CLIP-seq
MIRT2435431	hsa-miR-4530	CLIP-seq
MIRT788636	hsa-miR-454	CLIP-seq
MIRT2172883	hsa-miR-4659a-3p	CLIP-seq
MIRT2172884	hsa-miR-4659b-3p	CLIP-seq
MIRT2476050	hsa-miR-4668-3p	CLIP-seq
MIRT788638	hsa-miR-4671-3p	CLIP-seq
MIRT788687	hsa-miR-4684-5p	CLIP-seq
MIRT2476051	hsa-miR-4685-5p	CLIP-seq
MIRT1932607	hsa-miR-4686	CLIP-seq
MIRT788641	hsa-miR-4701-3p	CLIP-seq
MIRT2476052	hsa-miR-4715-3p	CLIP-seq
MIRT2476053	hsa-miR-4719	CLIP-seq
MIRT1932609	hsa-miR-4725-5p	CLIP-seq
MIRT788598	hsa-miR-4728-5p	CLIP-seq
MIRT1932610	hsa-miR-4733-5p	CLIP-seq
MIRT2476054	hsa-miR-4735-5p	CLIP-seq
MIRT1932611	hsa-miR-4772-3p	CLIP-seq
MIRT2443776	hsa-miR-4786-5p	CLIP-seq
MIRT788645	hsa-miR-4793-3p	CLIP-seq
MIRT788646	hsa-miR-485-5p	CLIP-seq
MIRT2476055	hsa-miR-499-5p	CLIP-seq
MIRT1932613	hsa-miR-504	CLIP-seq
MIRT788647	hsa-miR-508-5p	CLIP-seq
MIRT2476056	hsa-miR-513b	CLIP-seq
MIRT2435432	hsa-miR-539	CLIP-seq
MIRT788688	hsa-miR-548c-3p	CLIP-seq
MIRT2435433	hsa-miR-548v	CLIP-seq
MIRT2435434	hsa-miR-549	CLIP-seq
MIRT2443779	hsa-miR-593	CLIP-seq
MIRT2476057	hsa-miR-641	CLIP-seq
MIRT2435435	hsa-miR-646	CLIP-seq
MIRT788663	hsa-miR-661	CLIP-seq
MIRT788664	hsa-miR-766	CLIP-seq
MIRT2443781	hsa-miR-769-5p	CLIP-seq
MIRT2172883	hsa-miR-4659a-3p	CLIP-seq
MIRT2172884	hsa-miR-4659b-3p	CLIP-seq
MIRT2172883	hsa-miR-4659a-3p	CLIP-seq
MIRT2172884	hsa-miR-4659b-3p	CLIP-seq

Show/Hide all (6)

Transcription factor	Regulation	Reference
E2F1	Activation	12149244;12766778;17600109
E2F1	Unknown	15972851
E2F6	Repression	17600109
HDAC2	Repression	18834886
SP1	Unknown	15972851
TP53	Unknown	11896574;15972851

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000166	Function	Nucleotide binding	TAS	10383829
GO:0001666	Process	Response to hypoxia	IEA
GO:0001822	Process	Kidney development	IEA
GO:0001843	Process	Neural tube closure	IEA
GO:0005515	Function	Protein binding	IPI	9267021, 9922454, 10206961, 10376594, 10949025, 11112785, 11821383, 15735003, 17274640, 19494828, 20462491, 21371431, 21827945, 22246185
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	9267021
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	9753320
GO:0007399	Process	Nervous system development	TAS	9753320
GO:0007420	Process	Brain development	IEA
GO:0007584	Process	Response to nutrient	IEA
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	IEA
GO:0010659	Process	Cardiac muscle cell apoptotic process	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030900	Process	Forebrain development	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	11821383
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	TAS	10441496
GO:0043065	Process	Positive regulation of apoptotic process	IDA	9267021, 21827945
GO:0043065	Process	Positive regulation of apoptotic process	TAS	18309324
GO:0043293	Component	Apoptosome	IDA	21827945
GO:0043293	Component	Apoptosome	IEA
GO:0043293	Component	Apoptosome	IPI	10206961
GO:0043293	Component	Apoptosome	TAS	18309324
GO:0043531	Function	ADP binding	IEA
GO:0048731	Process	System development	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071560	Process	Cellular response to transforming growth factor beta stimulus	IEA
GO:0072432	Process	Response to G1 DNA damage checkpoint signaling	TAS	18309324
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	NAS	10206961
GO:0097193	Process	Intrinsic apoptotic signaling pathway	TAS	18309324
GO:0140608	Function	Cysteine-type endopeptidase activator activity	NAS	15009102
GO:0140608	Function	Cysteine-type endopeptidase activator activity	TAS	9267021
GO:1902510	Process	Regulation of apoptotic DNA fragmentation	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
602233	576	ENSG00000120868

O14727

Protein name

Apoptotic protease-activating factor 1 (APAF-1)

Protein function

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO

PDB

1C15 , 1CWW , 1CY5 , 1Z6T , 2P1H , 2YGS , 3J2T , 3JBT , 3YGS , 4RHW , 5JUY , 5WVC , 5WVE , 8XQK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00619	CARD	6 → 90	Caspase recruitment domain	Domain
PF00931	NB-ARC	129 → 374	NB-ARC domain	Domain
PF17908	APAF1_C	453 → 587	APAF-1 helical domain	Domain
PF00400	WD40	605 → 643	WD domain, G-beta repeat	Repeat
PF00400	WD40	647 → 685	WD domain, G-beta repeat	Repeat
PF00400	WD40	689 → 729	WD domain, G-beta repeat	Repeat
PF00400	WD40	733 → 771	WD domain, G-beta repeat	Repeat
PF00400	WD40	872 → 910	WD domain, G-beta repeat	Repeat
PF00400	WD40	992 → 1031	WD domain, G-beta repeat	Repeat
PF00400	WD40	1075 → 1113	WD domain, G-beta repeat	Repeat
PF00400	WD40	1118 → 1155	WD domain, G-beta repeat	Repeat
PF00400	WD40	1167 → 1203	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.

Sequence

MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE

Sequence length

1248

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Legionellosis Tuberculosis Hepatitis C Hepatitis B Measles Influenza A Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Small cell lung cancer Lipid and atherosclerosis		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
APAF1-related disorder	Benign; Likely benign	rs138526583, rs148854272, rs143097832, rs749682848, rs144749677, rs147249307, rs118102803, rs766273568, rs199829267, rs755943177, rs755498688, rs1226018795, rs146238655, rs779183383, rs57171247 View all (6 more)	RCV003929385 RCV003907065 RCV003907236 RCV003919586 RCV003914674 RCV003941813 RCV003924343 RCV003924352 RCV003924491 RCV003924526 RCV003917349 RCV003979083 RCV003982074 RCV003969100 RCV003915804 RCV003928454 RCV003920600 RCV003920520 RCV003957971 RCV003932932 RCV003915930
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs745962333	RCV004560084
Familial cancer of breast	Uncertain significance	rs150056794	RCV005928902
Neural tube defect	Uncertain significance	rs1565850856	RCV000709688
Nonpapillary renal cell carcinoma	Uncertain significance	rs150056794	RCV005928903

Show/Hide Text Mining Associations (66)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	27153549
Arthritis Rheumatoid	Associate	24920239
Astrocytoma	Associate	15367334
Brain Neoplasms	Associate	18093951
Breast Neoplasms	Inhibit	20829044
Burkitt Lymphoma	Associate	15692060
Calcinosis Cutis	Inhibit	15305193
Carcinogenesis	Associate	20977544
Carcinoma Embryonal	Inhibit	20977544
Carcinoma Hepatocellular	Associate	27342975, 31094091
Carcinoma Non Small Cell Lung	Associate	31329620
Carcinoma Renal Cell	Associate	17133271, 21922274
Carcinoma Transitional Cell	Associate	17133271, 17160380, 17541304
Cerebral Infarction	Associate	35432334
Cleft Palate	Associate	26743285
Colonic Neoplasms	Associate	21528061, 36866552
Colonic Polyps	Associate	26743285
Colorectal Neoplasms	Associate	22481083, 24992592, 28423356
Crohn Disease	Associate	12477763
Diabetic Nephropathies	Associate	27141571
Glioblastoma	Associate	14655749, 23822711
Glioma	Associate	11870542
HIV Infections	Stimulate	31779701
Huntington Disease	Stimulate	31329620
Hypoxia	Associate	19061491
Hypoxia Brain	Associate	31911497
Iron Overload	Stimulate	24142530
Kashin Beck Disease	Associate	22776318
Laryngeal Neoplasms	Associate	29503530
Leukemia	Associate	11435311, 11895790
Leukemia Myeloid Acute	Associate	15972851
Lung Neoplasms	Associate	28895780, 34308964
Lymphatic Metastasis	Associate	28453462
Lymphoma B Cell	Associate	15692060
Lymphoma Large B Cell Diffuse	Associate	27863378
Melanoma	Inhibit	15305193
Melanoma	Associate	19383853, 20216471, 20977544, 31329620, 36351409
Melanoma Cutaneous Malignant	Inhibit	15305193
Mitochondrial Diseases	Stimulate	12644018
Mitochondrial Diseases	Associate	24920239, 31541852
Monoclonal Gammopathy of Undetermined Significance	Associate	24816239
Multiple Myeloma	Associate	17557868, 24816239, 31918281
Myelodysplastic Syndromes	Associate	24142530
Nasopharyngeal Carcinoma	Associate	24845412, 31634779
Neoplasms	Associate	10722681, 11346470, 14655749, 16315248, 17133271, 17541304, 18093951, 19061491, 20572035, 20977544, 25064172, 29606096, 36142793, 36866552
Neoplasms	Inhibit	15972851, 17160380, 17557868, 20829044, 21922274, 23408418, 31094091, 36864125
Neoplasms	Stimulate	23613234
Neoplasms Germ Cell and Embryonal	Associate	20977544
Neural Tube Defects	Associate	29358613
Nevus Pigmented	Associate	12535197
Ovarian Neoplasms	Associate	11429402, 20925046
Paraproteinemias	Associate	24816239
Parkinson Disease	Stimulate	37108258
Polyps	Associate	26743285
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27644318
Prostatic Neoplasms	Associate	33509203
Pulmonary Disease Chronic Obstructive	Associate	38162988
Rectal Neoplasms	Associate	16315248
Retinal Dysplasia	Associate	26743285
Seminoma	Stimulate	20977544
Solitary Fibrous Tumors	Associate	34502329
Squamous Cell Carcinoma of Head and Neck	Associate	17026852, 28453462
Stomach Neoplasms	Associate	17876870, 23326121, 32993565
Teratoma	Inhibit	20977544
Testicular Germ Cell Tumor	Associate	20977544
Urinary Bladder Neoplasms	Associate	17160380, 17541304, 23613234

APAF1 (apoptotic peptidase activating factor 1)