Gene Gene information from NCBI Gene database.
Entrez ID 3148
Gene name High mobility group box 2
Gene symbol HMGB2
Synonyms (NCBI Gene)
HMG2
Chromosome 4
Chromosome location 4q34.1
Summary This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated t
miRNA miRNA information provided by mirtarbase database.
603
miRTarBase ID miRNA Experiments Reference
MIRT025152 hsa-miR-181a-5p Microarray 17612493
MIRT028203 hsa-miR-33a-5p Sequencing 20371350
MIRT030580 hsa-miR-24-3p Microarray 19748357
MIRT044016 hsa-miR-374a-5p CLASH 23622248
MIRT438692 hsa-miR-23a-3p Luciferase reporter assayqRT-PCRWestern blot 23986579
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
87
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 11748232
GO:0000400 Function Four-way junction DNA binding ISS
GO:0000785 Component Chromatin IEA
GO:0000785 Component Chromatin ISS
GO:0000793 Component Condensed chromosome IDA 12925773
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
163906 5000 ENSG00000164104
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P26583
Protein name High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Protein function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2 6 79 HMG-box domain Domain
PF00505 HMG_box 95 163 HMG (high mobility group) box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in gastric and intestinal tissues (at protein level). {ECO:0000269|PubMed:23877675}.
Sequence
Sequence length 209
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Apoptosis induced DNA fragmentation