Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3148
Gene name Gene Name - the full gene name approved by the HGNC.
High mobility group box 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HMGB2
Synonyms (NCBI Gene) Gene synonyms aliases
HMG2
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q34.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated t
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025152 hsa-miR-181a-5p Microarray 17612493
MIRT028203 hsa-miR-33a-5p Sequencing 20371350
MIRT030580 hsa-miR-24-3p Microarray 19748357
MIRT044016 hsa-miR-374a-5p CLASH 23622248
MIRT438692 hsa-miR-23a-3p Luciferase reporter assay, qRT-PCR, Western blot 23986579
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000400 Function Four-way junction DNA binding ISS
GO:0000785 Component Chromatin ISS
GO:0000793 Component Condensed chromosome IDA 12925773
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 19965638
GO:0000987 Function Cis-regulatory region sequence-specific DNA binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
163906 5000 ENSG00000164104
Protein
UniProt ID P26583
Protein name High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Protein function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2 6 79 HMG-box domain Domain
PF00505 HMG_box 95 163 HMG (high mobility group) box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in gastric and intestinal tissues (at protein level). {ECO:0000269|PubMed:23877675}.
Sequence
Sequence length 209
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Apoptosis induced DNA fragmentation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
24366584, 27602772
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
20882379
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29877212
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Inhibit 26418742
Aortic Valve Calcification of Associate 36958298
Arthritis Associate 24905701
Brain Neoplasms Associate 38256095
Breast Neoplasms Inhibit 22655796
Calcinosis Associate 36958298
Carcinogenesis Associate 35403252
Carcinoma Hepatocellular Associate 37903974, 39247201, 39591457
Carcinoma Non Small Cell Lung Associate 10076573, 30446524
Carcinoma Pancreatic Ductal Associate 25060178, 35403252