Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3099
Gene name Gene Name - the full gene name approved by the HGNC.
Hexokinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HK2
Synonyms (NCBI Gene) Gene synonyms aliases
HKII, HXK2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p12
Summary Summary of gene provided in NCBI Entrez Gene.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expres
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006301 hsa-miR-143-3p Luciferase reporter assay 22354042
MIRT006301 hsa-miR-143-3p Luciferase reporter assay 22354042
MIRT006301 hsa-miR-143-3p Luciferase reporter assay 22354042
MIRT006301 hsa-miR-143-3p Luciferase reporter assay 22354042
MIRT006301 hsa-miR-143-3p Luciferase reporter assay 22354042
Transcription factors
Transcription factor Regulation Reference
SREBF1 Unknown 14747281
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001678 Process Cellular glucose homeostasis IBA 21873635
GO:0002931 Process Response to ischemia IEA
GO:0004340 Function Glucokinase activity IBA 21873635
GO:0004340 Function Glucokinase activity IDA 29298880
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601125 4923 ENSG00000159399
Protein
UniProt ID P52789
Protein name Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Protein function Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of g
PDB 2NZT , 5HEX , 5HFU , 5HG1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00349 Hexokinase_1 21 219 Hexokinase Domain
PF03727 Hexokinase_2 225 459 Hexokinase Domain
PF00349 Hexokinase_1 469 667 Hexokinase Domain
PF03727 Hexokinase_2 673 907 Hexokinase Domain
Tissue specificity TISSUE SPECIFICITY: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. {ECO:0000269|PubMed:8250948}.
Sequence
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY
DDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAV
AYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGF
EDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAV
ACRIREAGQR
Sequence length 917
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycolysis / Gluconeogenesis
Fructose and mannose metabolism
Galactose metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Neomycin, kanamycin and gentamicin biosynthesis
Metabolic pathways
Carbon metabolism
Biosynthesis of nucleotide sugars
HIF-1 signaling pathway
Insulin signaling pathway
Type II diabetes mellitus
Carbohydrate digestion and absorption
Shigellosis
Central carbon metabolism in cancer
  Glycolysis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
20882379
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21926974
Unknown
Disease term Disease name Evidence References Source
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 15967114
Adenocarcinoma of Lung Associate 28423489, 31186081, 35379058, 36320008, 36960858
Anophthalmia with pulmonary hypoplasia Associate 32633891
Arthritis Rheumatoid Stimulate 34160468
Arthritis Rheumatoid Associate 35720293
Atypical Squamous Cells of the Cervix Associate 26097593
Brain Neoplasms Stimulate 19723875
Brain Neoplasms Associate 32372141
Breast Neoplasms Associate 10646889, 16595493, 17317033, 23598413, 23869589, 25926654, 32020848, 35260660, 35328104, 36335239, 36913368, 37377974
Breast Neoplasms Stimulate 19723875