HGFAC (HGF activator)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3083
Gene name Gene Name - the full gene name approved by the HGNC.
HGF activator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HGFAC
Synonyms (NCBI Gene) Gene synonyms aliases
HGFA
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p16.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that con
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT019046 hsa-miR-335-5p Microarray 18185580
MIRT572586 hsa-miR-3607-3p PAR-CLIP 20371350
MIRT572585 hsa-miR-3686 PAR-CLIP 20371350
MIRT572584 hsa-miR-4273 PAR-CLIP 20371350
MIRT572583 hsa-miR-7156-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS 7683665
GO:0005515 Function Protein binding IPI 15713485, 32296183, 33961781
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604552 4894 ENSG00000109758
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q04756
Protein name Hepatocyte growth factor activator serine protease (HGF activator) (HGFA) (HGFA serine protease) (EC 3.4.21.-) (Serine protease HGFAC) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
Protein function Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.
PDB 1YBW , 1YC0 , 2R0K , 2R0L , 2WUB , 2WUC , 3K2U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00040 fn2 108 → 148 Fibronectin type II domain Domain
PF00039 fn1 202 → 237 Fibronectin type I domain Domain
PF00008 EGF 245 → 277 EGF-like domain Domain
PF00051 Kringle 286 → 367 Kringle domain Domain
PF00089 Trypsin 408 → 641 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Liver.
Sequence
Sequence length 655
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    MET Receptor Activation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (22)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 32856461
Carcinoma Hepatocellular Associate 32443377, 33879119
Chemical and Drug Induced Liver Injury Associate 38034020
Colorectal Neoplasms Associate 28502252, 36868002
Diabetes Mellitus Associate 36585034
Diabetes Mellitus Type 2 Associate 30649532
Glioblastoma Associate 7556648
Glioma Associate 7556648
Glomerulonephritis IGA Associate 32856461
Hypoxia Stimulate 18422749