HGFAC (HGF activator)

Gene

• Entrez ID: 3083
• Gene name: HGF activator
• Gene symbol: HGFAC
• Synonyms (NCBI Gene): HGFA
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that con

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019046	hsa-miR-335-5p	Microarray	18185580
MIRT572586	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT572585	hsa-miR-3686	PAR-CLIP	20371350
MIRT572584	hsa-miR-4273	PAR-CLIP	20371350
MIRT572583	hsa-miR-7156-5p	PAR-CLIP	20371350
MIRT572582	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT572581	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT527734	hsa-miR-4311	PAR-CLIP	22012620
MIRT527733	hsa-miR-3185	PAR-CLIP	22012620
MIRT527732	hsa-miR-3611	PAR-CLIP	22012620
MIRT527732	hsa-miR-3611	PAR-CLIP	27292025
MIRT527734	hsa-miR-4311	PAR-CLIP	27292025
MIRT572586	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT572585	hsa-miR-3686	PAR-CLIP	20371350
MIRT572584	hsa-miR-4273	PAR-CLIP	20371350
MIRT572583	hsa-miR-7156-5p	PAR-CLIP	20371350
MIRT572582	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT572581	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT527734	hsa-miR-4311	PAR-CLIP	22012620
MIRT527733	hsa-miR-3185	PAR-CLIP	22012620
MIRT527732	hsa-miR-3611	PAR-CLIP	22012620

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	TAS	7683665
GO:0005515	Function	Protein binding	IPI	15713485, 32296183, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS	7683665
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IBA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	8226803
GO:0007596	Process	Blood coagulation	IBA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	8226803
GO:0016787	Function	Hydrolase activity	IEA
GO:0031638	Process	Zymogen activation	IBA

Other IDs

• MIM: 604552
• HGNC: 4894
• e!Ensembl: ENSG00000109758

Protein

• UniProt ID: Q04756
• Protein name: Hepatocyte growth factor activator serine protease (HGF activator) (HGFA) (HGFA serine protease) (EC 3.4.21.-) (Serine protease HGFAC) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
• Protein function: Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.
• PDB: 1YBW, 1YC0, 2R0K, 2R0L, 2WUB, 2WUC, 3K2U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00040	fn2	108 → 148	Fibronectin type II domain	Domain
  PF00039	fn1	202 → 237	Fibronectin type I domain	Domain
  PF00008	EGF	245 → 277	EGF-like domain	Domain
  PF00051	Kringle	286 → 367	Kringle domain	Domain
  PF00089	Trypsin	408 → 641	Trypsin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Liver.
• Sequence:

  MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
  TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
  ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
  PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
  RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
  SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
  YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
  WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
  KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
  GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
  PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS

• Sequence length: 655

Pathways

Reactome:

MET Receptor Activation