Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3069
Gene name Gene Name - the full gene name approved by the HGNC.
High density lipoprotein binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HDLBP
Synonyms (NCBI Gene) Gene synonyms aliases
HBP, PRO2900, VGL
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025358 hsa-miR-34a-5p Proteomics 21566225
MIRT025358 hsa-miR-34a-5p Proteomics 21566225
MIRT025699 hsa-miR-7-5p Microarray 19073608
MIRT046605 hsa-miR-222-3p CLASH 23622248
MIRT044029 hsa-miR-365a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 24725430
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
142695 4857 ENSG00000115677
Protein
UniProt ID Q00341
Protein name Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)
Protein function Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
PDB 1VIG , 1VIH , 2CTE , 2CTF , 2CTJ , 2CTK , 2CTL , 2CTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00013 KH_1 152 214 KH domain Domain
PF00013 KH_1 224 286 KH domain Domain
PF00013 KH_1 297 359 KH domain Domain
PF00013 KH_1 366 426 KH domain Domain
PF00013 KH_1 437 499 KH domain Domain
PF00013 KH_1 509 572 KH domain Domain
PF00013 KH_1 581 645 KH domain Domain
PF00013 KH_1 655 718 KH domain Domain
PF00013 KH_1 729 792 KH domain Domain
PF00013 KH_1 802 865 KH domain Domain
PF00013 KH_1 875 969 KH domain Domain
PF00013 KH_1 974 1036 KH domain Domain
PF00013 KH_1 1054 1119 KH domain Domain
PF00013 KH_1 1129 1192 KH domain Domain
Sequence
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP
SGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA
KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLL
ISAEQDKRAVERLEVEKAFHPFIAGP
YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKK
IYEEKKKKTTTIAV
EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYA
K
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA
QEQIEG
MVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL
IRIEGDPQGVQQAKRELLE
LASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQK
MVADLVENSYSISVPIFKQFHKNIIGKG
GANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILS
IQKDLANIAEVEVSI
PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLH
LA
EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKE
DAVREAQKELEA
LIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS
GTQSDKVTLKGAKDCVEAAKKRIQE
IIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQIT
RDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKC
EAAKEALEA
LVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAI
TGLAANLDRAKAGLLE
RVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL
EHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILR
IVGELEQMVSEDVPLDHRVHA
RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILN
LEEEYLAD
VVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK
TLPWGPKR
Sequence length 1268
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HDL clearance
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
2q37 deletion syndrome Chromosome 2q37 deletion syndrome rs748900140, rs1064797002 19365831
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
19365831
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Lymphocytic Leukemia Lymphocytic Leukemia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 33941620
Autistic Disorder Associate 33941620
Breast Neoplasms Inhibit 20974809
Breast Neoplasms Associate 22302350, 33941620
Carcinoma Hepatocellular Associate 36122630
Carcinoma Hepatocellular Stimulate 36244648, 36423520
Coronary Artery Disease Associate 39614436
Leukemia Myelogenous Chronic BCR ABL Positive Associate 27534394
Mesothelioma Malignant Associate 36323745
Neoplasm Metastasis Associate 36122630