HAS3 (hyaluronan synthase 3)

Gene

• Entrez ID: 3038
• Gene name: Hyaluronan synthase 3
• Gene symbol: HAS3
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2232228	A>C,G	Drug-response	Synonymous variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024770	hsa-miR-215-5p	Microarray	19074876
MIRT026580	hsa-miR-192-5p	Microarray	19074876
MIRT536973	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT536972	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT536971	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT536970	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT536969	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT536968	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT536967	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT536966	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT242427	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT242426	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT242425	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536965	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536964	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536963	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536962	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536961	hsa-miR-302e	PAR-CLIP	22012620
MIRT536960	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536959	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536958	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536957	hsa-miR-520b	PAR-CLIP	22012620
MIRT536956	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536955	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536954	hsa-miR-520e	PAR-CLIP	22012620
MIRT536953	hsa-miR-3163	PAR-CLIP	22012620
MIRT242424	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536952	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT536951	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT536973	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT536972	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT536971	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT536970	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT536969	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT536968	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT536967	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT536966	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT242427	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT242426	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT242425	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536965	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536964	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536963	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536962	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536961	hsa-miR-302e	PAR-CLIP	22012620
MIRT536960	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536959	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536958	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536957	hsa-miR-520b	PAR-CLIP	22012620
MIRT536956	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536955	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536954	hsa-miR-520e	PAR-CLIP	22012620
MIRT536953	hsa-miR-3163	PAR-CLIP	22012620
MIRT242424	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536952	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT536951	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040885	hsa-miR-1225-3p	CLIP-seq
MIRT1040886	hsa-miR-1228	CLIP-seq
MIRT1040887	hsa-miR-1233	CLIP-seq
MIRT1040888	hsa-miR-1238	CLIP-seq
MIRT1040889	hsa-miR-1272	CLIP-seq
MIRT1040890	hsa-miR-1322	CLIP-seq
MIRT1040891	hsa-miR-134	CLIP-seq
MIRT1040892	hsa-miR-136	CLIP-seq
MIRT1040893	hsa-miR-155	CLIP-seq
MIRT1040894	hsa-miR-224	CLIP-seq
MIRT1040895	hsa-miR-2355-3p	CLIP-seq
MIRT1040896	hsa-miR-24	CLIP-seq
MIRT1040897	hsa-miR-3118	CLIP-seq
MIRT1040898	hsa-miR-3121-5p	CLIP-seq
MIRT1040899	hsa-miR-3130-3p	CLIP-seq
MIRT1040900	hsa-miR-3132	CLIP-seq
MIRT1040901	hsa-miR-3167	CLIP-seq
MIRT1040902	hsa-miR-3612	CLIP-seq
MIRT1040903	hsa-miR-3613-3p	CLIP-seq
MIRT1040904	hsa-miR-3614-5p	CLIP-seq
MIRT1040905	hsa-miR-3619-3p	CLIP-seq
MIRT1040906	hsa-miR-3664-3p	CLIP-seq
MIRT1040907	hsa-miR-3682-3p	CLIP-seq
MIRT1040908	hsa-miR-371b-5p	CLIP-seq
MIRT1040909	hsa-miR-377	CLIP-seq
MIRT1040910	hsa-miR-4284	CLIP-seq
MIRT1040911	hsa-miR-4293	CLIP-seq
MIRT1040912	hsa-miR-4325	CLIP-seq
MIRT1040913	hsa-miR-4418	CLIP-seq
MIRT1040914	hsa-miR-4433	CLIP-seq
MIRT1040915	hsa-miR-4459	CLIP-seq
MIRT1040916	hsa-miR-4474-3p	CLIP-seq
MIRT1040917	hsa-miR-4480	CLIP-seq
MIRT1040918	hsa-miR-451b	CLIP-seq
MIRT1040919	hsa-miR-4520b-3p	CLIP-seq
MIRT1040920	hsa-miR-4529-3p	CLIP-seq
MIRT1040921	hsa-miR-4535	CLIP-seq
MIRT1040922	hsa-miR-4539	CLIP-seq
MIRT1040923	hsa-miR-4641	CLIP-seq
MIRT1040924	hsa-miR-4643	CLIP-seq
MIRT1040925	hsa-miR-4646-3p	CLIP-seq
MIRT1040926	hsa-miR-4650-3p	CLIP-seq
MIRT1040927	hsa-miR-4680-5p	CLIP-seq
MIRT1040928	hsa-miR-4691-5p	CLIP-seq
MIRT1040929	hsa-miR-4695-5p	CLIP-seq
MIRT1040930	hsa-miR-4698	CLIP-seq
MIRT1040931	hsa-miR-4712-3p	CLIP-seq
MIRT1040932	hsa-miR-4766-5p	CLIP-seq
MIRT1040933	hsa-miR-4768-3p	CLIP-seq
MIRT1040934	hsa-miR-4776-5p	CLIP-seq
MIRT1040935	hsa-miR-4777-3p	CLIP-seq
MIRT1040936	hsa-miR-4793-3p	CLIP-seq
MIRT1040937	hsa-miR-509-3-5p	CLIP-seq
MIRT1040938	hsa-miR-509-5p	CLIP-seq
MIRT1040939	hsa-miR-548aa	CLIP-seq
MIRT1040940	hsa-miR-548ac	CLIP-seq
MIRT1040941	hsa-miR-548d-3p	CLIP-seq
MIRT1040942	hsa-miR-548z	CLIP-seq
MIRT1040943	hsa-miR-576-5p	CLIP-seq
MIRT1040944	hsa-miR-647	CLIP-seq
MIRT1040945	hsa-miR-650	CLIP-seq
MIRT1040946	hsa-miR-676	CLIP-seq
MIRT1040947	hsa-miR-875-5p	CLIP-seq
MIRT1040948	hsa-miR-876-5p	CLIP-seq
MIRT1040949	hsa-miR-941	CLIP-seq
MIRT1040950	hsa-miR-943	CLIP-seq
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040885	hsa-miR-1225-3p	CLIP-seq
MIRT1040887	hsa-miR-1233	CLIP-seq
MIRT1040951	hsa-miR-1252	CLIP-seq
MIRT1040952	hsa-miR-1275	CLIP-seq
MIRT1040953	hsa-miR-1299	CLIP-seq
MIRT1040954	hsa-miR-143	CLIP-seq
MIRT1040955	hsa-miR-216b	CLIP-seq
MIRT1040956	hsa-miR-3128	CLIP-seq
MIRT1040902	hsa-miR-3612	CLIP-seq
MIRT1040957	hsa-miR-3614-3p	CLIP-seq
MIRT1040906	hsa-miR-3664-3p	CLIP-seq
MIRT1040958	hsa-miR-3667-3p	CLIP-seq
MIRT1040959	hsa-miR-3677-3p	CLIP-seq
MIRT1040960	hsa-miR-370	CLIP-seq
MIRT1040961	hsa-miR-375	CLIP-seq
MIRT1040962	hsa-miR-3978	CLIP-seq
MIRT1040963	hsa-miR-4297	CLIP-seq
MIRT1040964	hsa-miR-4301	CLIP-seq
MIRT1040965	hsa-miR-4302	CLIP-seq
MIRT1040966	hsa-miR-4326	CLIP-seq
MIRT1040967	hsa-miR-4423-5p	CLIP-seq
MIRT1040914	hsa-miR-4433	CLIP-seq
MIRT1040915	hsa-miR-4459	CLIP-seq
MIRT1040968	hsa-miR-4470	CLIP-seq
MIRT1040918	hsa-miR-451b	CLIP-seq
MIRT1040969	hsa-miR-4525	CLIP-seq
MIRT1040970	hsa-miR-4665-5p	CLIP-seq
MIRT1040971	hsa-miR-4667-5p	CLIP-seq
MIRT1040972	hsa-miR-4690-5p	CLIP-seq
MIRT1040928	hsa-miR-4691-5p	CLIP-seq
MIRT1040929	hsa-miR-4695-5p	CLIP-seq
MIRT1040973	hsa-miR-4700-5p	CLIP-seq
MIRT1040931	hsa-miR-4712-3p	CLIP-seq
MIRT1040974	hsa-miR-4723-5p	CLIP-seq
MIRT1040975	hsa-miR-4742-5p	CLIP-seq
MIRT1040976	hsa-miR-4753-3p	CLIP-seq
MIRT1040977	hsa-miR-4763-5p	CLIP-seq
MIRT1040933	hsa-miR-4768-3p	CLIP-seq
MIRT1040978	hsa-miR-4770	CLIP-seq
MIRT1040979	hsa-miR-4782-5p	CLIP-seq
MIRT1040980	hsa-miR-486-5p	CLIP-seq
MIRT1040981	hsa-miR-516b	CLIP-seq
MIRT1040939	hsa-miR-548aa	CLIP-seq
MIRT1040940	hsa-miR-548ac	CLIP-seq
MIRT1040941	hsa-miR-548d-3p	CLIP-seq
MIRT1040942	hsa-miR-548z	CLIP-seq
MIRT1040982	hsa-miR-589	CLIP-seq
MIRT1040983	hsa-miR-625	CLIP-seq
MIRT1040984	hsa-miR-637	CLIP-seq
MIRT1040945	hsa-miR-650	CLIP-seq
MIRT1040985	hsa-miR-657	CLIP-seq
MIRT1040986	hsa-miR-659	CLIP-seq
MIRT1040987	hsa-miR-875-3p	CLIP-seq
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040891	hsa-miR-134	CLIP-seq
MIRT1040897	hsa-miR-3118	CLIP-seq
MIRT1040950	hsa-miR-943	CLIP-seq
MIRT2388906	hsa-miR-3622b-5p	CLIP-seq
MIRT2388907	hsa-miR-3688-5p	CLIP-seq
MIRT1040916	hsa-miR-4474-3p	CLIP-seq
MIRT2429501	hsa-miR-583	CLIP-seq
MIRT2544569	hsa-miR-1972	CLIP-seq
MIRT2544570	hsa-miR-3124-3p	CLIP-seq
MIRT1040968	hsa-miR-4470	CLIP-seq
MIRT2544571	hsa-miR-4650-5p	CLIP-seq
MIRT2544572	hsa-miR-499-3p	CLIP-seq
MIRT2544573	hsa-miR-499a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000271	Process	Polysaccharide biosynthetic process	IBA
GO:0000271	Process	Polysaccharide biosynthetic process	IEA
GO:0000271	Process	Polysaccharide biosynthetic process	ISS
GO:0005515	Function	Protein binding	IPI	20507985, 25795779, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	25795779
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25795779, 26883802
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9169154
GO:0005975	Process	Carbohydrate metabolic process	TAS	9169154
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9083017
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	IBA
GO:0030213	Process	Hyaluronan biosynthetic process	IDA	16900089
GO:0030213	Process	Hyaluronan biosynthetic process	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	TAS
GO:0036117	Component	Hyaluranon cable	IDA	16900089
GO:0042802	Function	Identical protein binding	IPI	25795779
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	16900089
GO:0050501	Function	Hyaluronan synthase activity	IBA
GO:0050501	Function	Hyaluronan synthase activity	IDA	16900089, 23303191
GO:0050501	Function	Hyaluronan synthase activity	IEA
GO:0050501	Function	Hyaluronan synthase activity	TAS
GO:0085029	Process	Extracellular matrix assembly	IBA
GO:0085029	Process	Extracellular matrix assembly	IEA
GO:0085029	Process	Extracellular matrix assembly	ISS
GO:1900106	Process	Positive regulation of hyaluranon cable assembly	IDA	16900089

Other IDs

• MIM: 602428
• HGNC: 4820
• e!Ensembl: ENSG00000103044

Protein

• UniProt ID: O00219
• Protein name: Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3)
• Protein function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13641	Glyco_tranf_2_3	154 → 360		Domain

• Sequence:

  MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
  LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
  VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
  STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
  VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
  DWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKS
  YFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVG
  IIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIG
  LIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCG
  KKPEQYSLAFAEV

• Sequence length: 553

Pathways

Reactome:

Hyaluronan biosynthesis and export