Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3038
Gene name Gene Name - the full gene name approved by the HGNC.	Hyaluronan synthase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HAS3
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the

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SNP ID	Visualize variation	Clinical significance	Consequence
rs2232228	A>C,G	Drug-response	Synonymous variant, coding sequence variant

Show/Hide all(191)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024770	hsa-miR-215-5p	Microarray	19074876
MIRT026580	hsa-miR-192-5p	Microarray	19074876
MIRT536973	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT536972	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT536971	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT536970	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT536969	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT536968	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT536967	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT536966	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT242427	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT242426	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT242425	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536965	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536964	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536963	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536962	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536961	hsa-miR-302e	PAR-CLIP	22012620
MIRT536960	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536959	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536958	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536957	hsa-miR-520b	PAR-CLIP	22012620
MIRT536956	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536955	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536954	hsa-miR-520e	PAR-CLIP	22012620
MIRT536953	hsa-miR-3163	PAR-CLIP	22012620
MIRT242424	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536952	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT536951	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT536973	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT536972	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT536971	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT536970	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT536969	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT536968	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT536967	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT536966	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT242427	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT242426	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT242425	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536965	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536964	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536963	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536962	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536961	hsa-miR-302e	PAR-CLIP	22012620
MIRT536960	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536959	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536958	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536957	hsa-miR-520b	PAR-CLIP	22012620
MIRT536956	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536955	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536954	hsa-miR-520e	PAR-CLIP	22012620
MIRT536953	hsa-miR-3163	PAR-CLIP	22012620
MIRT242424	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536952	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT536951	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040885	hsa-miR-1225-3p	CLIP-seq
MIRT1040886	hsa-miR-1228	CLIP-seq
MIRT1040887	hsa-miR-1233	CLIP-seq
MIRT1040888	hsa-miR-1238	CLIP-seq
MIRT1040889	hsa-miR-1272	CLIP-seq
MIRT1040890	hsa-miR-1322	CLIP-seq
MIRT1040891	hsa-miR-134	CLIP-seq
MIRT1040892	hsa-miR-136	CLIP-seq
MIRT1040893	hsa-miR-155	CLIP-seq
MIRT1040894	hsa-miR-224	CLIP-seq
MIRT1040895	hsa-miR-2355-3p	CLIP-seq
MIRT1040896	hsa-miR-24	CLIP-seq
MIRT1040897	hsa-miR-3118	CLIP-seq
MIRT1040898	hsa-miR-3121-5p	CLIP-seq
MIRT1040899	hsa-miR-3130-3p	CLIP-seq
MIRT1040900	hsa-miR-3132	CLIP-seq
MIRT1040901	hsa-miR-3167	CLIP-seq
MIRT1040902	hsa-miR-3612	CLIP-seq
MIRT1040903	hsa-miR-3613-3p	CLIP-seq
MIRT1040904	hsa-miR-3614-5p	CLIP-seq
MIRT1040905	hsa-miR-3619-3p	CLIP-seq
MIRT1040906	hsa-miR-3664-3p	CLIP-seq
MIRT1040907	hsa-miR-3682-3p	CLIP-seq
MIRT1040908	hsa-miR-371b-5p	CLIP-seq
MIRT1040909	hsa-miR-377	CLIP-seq
MIRT1040910	hsa-miR-4284	CLIP-seq
MIRT1040911	hsa-miR-4293	CLIP-seq
MIRT1040912	hsa-miR-4325	CLIP-seq
MIRT1040913	hsa-miR-4418	CLIP-seq
MIRT1040914	hsa-miR-4433	CLIP-seq
MIRT1040915	hsa-miR-4459	CLIP-seq
MIRT1040916	hsa-miR-4474-3p	CLIP-seq
MIRT1040917	hsa-miR-4480	CLIP-seq
MIRT1040918	hsa-miR-451b	CLIP-seq
MIRT1040919	hsa-miR-4520b-3p	CLIP-seq
MIRT1040920	hsa-miR-4529-3p	CLIP-seq
MIRT1040921	hsa-miR-4535	CLIP-seq
MIRT1040922	hsa-miR-4539	CLIP-seq
MIRT1040923	hsa-miR-4641	CLIP-seq
MIRT1040924	hsa-miR-4643	CLIP-seq
MIRT1040925	hsa-miR-4646-3p	CLIP-seq
MIRT1040926	hsa-miR-4650-3p	CLIP-seq
MIRT1040927	hsa-miR-4680-5p	CLIP-seq
MIRT1040928	hsa-miR-4691-5p	CLIP-seq
MIRT1040929	hsa-miR-4695-5p	CLIP-seq
MIRT1040930	hsa-miR-4698	CLIP-seq
MIRT1040931	hsa-miR-4712-3p	CLIP-seq
MIRT1040932	hsa-miR-4766-5p	CLIP-seq
MIRT1040933	hsa-miR-4768-3p	CLIP-seq
MIRT1040934	hsa-miR-4776-5p	CLIP-seq
MIRT1040935	hsa-miR-4777-3p	CLIP-seq
MIRT1040936	hsa-miR-4793-3p	CLIP-seq
MIRT1040937	hsa-miR-509-3-5p	CLIP-seq
MIRT1040938	hsa-miR-509-5p	CLIP-seq
MIRT1040939	hsa-miR-548aa	CLIP-seq
MIRT1040940	hsa-miR-548ac	CLIP-seq
MIRT1040941	hsa-miR-548d-3p	CLIP-seq
MIRT1040942	hsa-miR-548z	CLIP-seq
MIRT1040943	hsa-miR-576-5p	CLIP-seq
MIRT1040944	hsa-miR-647	CLIP-seq
MIRT1040945	hsa-miR-650	CLIP-seq
MIRT1040946	hsa-miR-676	CLIP-seq
MIRT1040947	hsa-miR-875-5p	CLIP-seq
MIRT1040948	hsa-miR-876-5p	CLIP-seq
MIRT1040949	hsa-miR-941	CLIP-seq
MIRT1040950	hsa-miR-943	CLIP-seq
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040885	hsa-miR-1225-3p	CLIP-seq
MIRT1040887	hsa-miR-1233	CLIP-seq
MIRT1040951	hsa-miR-1252	CLIP-seq
MIRT1040952	hsa-miR-1275	CLIP-seq
MIRT1040953	hsa-miR-1299	CLIP-seq
MIRT1040954	hsa-miR-143	CLIP-seq
MIRT1040955	hsa-miR-216b	CLIP-seq
MIRT1040956	hsa-miR-3128	CLIP-seq
MIRT1040902	hsa-miR-3612	CLIP-seq
MIRT1040957	hsa-miR-3614-3p	CLIP-seq
MIRT1040906	hsa-miR-3664-3p	CLIP-seq
MIRT1040958	hsa-miR-3667-3p	CLIP-seq
MIRT1040959	hsa-miR-3677-3p	CLIP-seq
MIRT1040960	hsa-miR-370	CLIP-seq
MIRT1040961	hsa-miR-375	CLIP-seq
MIRT1040962	hsa-miR-3978	CLIP-seq
MIRT1040963	hsa-miR-4297	CLIP-seq
MIRT1040964	hsa-miR-4301	CLIP-seq
MIRT1040965	hsa-miR-4302	CLIP-seq
MIRT1040966	hsa-miR-4326	CLIP-seq
MIRT1040967	hsa-miR-4423-5p	CLIP-seq
MIRT1040914	hsa-miR-4433	CLIP-seq
MIRT1040915	hsa-miR-4459	CLIP-seq
MIRT1040968	hsa-miR-4470	CLIP-seq
MIRT1040918	hsa-miR-451b	CLIP-seq
MIRT1040969	hsa-miR-4525	CLIP-seq
MIRT1040970	hsa-miR-4665-5p	CLIP-seq
MIRT1040971	hsa-miR-4667-5p	CLIP-seq
MIRT1040972	hsa-miR-4690-5p	CLIP-seq
MIRT1040928	hsa-miR-4691-5p	CLIP-seq
MIRT1040929	hsa-miR-4695-5p	CLIP-seq
MIRT1040973	hsa-miR-4700-5p	CLIP-seq
MIRT1040931	hsa-miR-4712-3p	CLIP-seq
MIRT1040974	hsa-miR-4723-5p	CLIP-seq
MIRT1040975	hsa-miR-4742-5p	CLIP-seq
MIRT1040976	hsa-miR-4753-3p	CLIP-seq
MIRT1040977	hsa-miR-4763-5p	CLIP-seq
MIRT1040933	hsa-miR-4768-3p	CLIP-seq
MIRT1040978	hsa-miR-4770	CLIP-seq
MIRT1040979	hsa-miR-4782-5p	CLIP-seq
MIRT1040980	hsa-miR-486-5p	CLIP-seq
MIRT1040981	hsa-miR-516b	CLIP-seq
MIRT1040939	hsa-miR-548aa	CLIP-seq
MIRT1040940	hsa-miR-548ac	CLIP-seq
MIRT1040941	hsa-miR-548d-3p	CLIP-seq
MIRT1040942	hsa-miR-548z	CLIP-seq
MIRT1040982	hsa-miR-589	CLIP-seq
MIRT1040983	hsa-miR-625	CLIP-seq
MIRT1040984	hsa-miR-637	CLIP-seq
MIRT1040945	hsa-miR-650	CLIP-seq
MIRT1040985	hsa-miR-657	CLIP-seq
MIRT1040986	hsa-miR-659	CLIP-seq
MIRT1040987	hsa-miR-875-3p	CLIP-seq
MIRT1040884	hsa-miR-105	CLIP-seq
MIRT1040891	hsa-miR-134	CLIP-seq
MIRT1040897	hsa-miR-3118	CLIP-seq
MIRT1040950	hsa-miR-943	CLIP-seq
MIRT2388906	hsa-miR-3622b-5p	CLIP-seq
MIRT2388907	hsa-miR-3688-5p	CLIP-seq
MIRT1040916	hsa-miR-4474-3p	CLIP-seq
MIRT2429501	hsa-miR-583	CLIP-seq
MIRT2544569	hsa-miR-1972	CLIP-seq
MIRT2544570	hsa-miR-3124-3p	CLIP-seq
MIRT1040968	hsa-miR-4470	CLIP-seq
MIRT2544571	hsa-miR-4650-5p	CLIP-seq
MIRT2544572	hsa-miR-499-3p	CLIP-seq
MIRT2544573	hsa-miR-499a-3p	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000271	Process	Polysaccharide biosynthetic process	IBA
GO:0000271	Process	Polysaccharide biosynthetic process	IEA
GO:0000271	Process	Polysaccharide biosynthetic process	ISS
GO:0005515	Function	Protein binding	IPI	20507985, 25795779, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	25795779
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25795779, 26883802
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9169154
GO:0005975	Process	Carbohydrate metabolic process	TAS	9169154
GO:0006024	Process	Glycosaminoglycan biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9083017
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	IBA
GO:0030213	Process	Hyaluronan biosynthetic process	IDA	16900089
GO:0030213	Process	Hyaluronan biosynthetic process	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	IEA
GO:0030213	Process	Hyaluronan biosynthetic process	TAS
GO:0036117	Component	Hyaluranon cable	IDA	16900089
GO:0042802	Function	Identical protein binding	IPI	25795779
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	16900089
GO:0050501	Function	Hyaluronan synthase activity	IBA
GO:0050501	Function	Hyaluronan synthase activity	IDA	16900089, 23303191
GO:0050501	Function	Hyaluronan synthase activity	IEA
GO:0050501	Function	Hyaluronan synthase activity	TAS
GO:0085029	Process	Extracellular matrix assembly	IBA
GO:0085029	Process	Extracellular matrix assembly	IEA
GO:0085029	Process	Extracellular matrix assembly	ISS
GO:1900106	Process	Positive regulation of hyaluranon cable assembly	IDA	16900089

MIM	HGNC	e!Ensembl
602428	4820	ENSG00000103044

Protein

UniProt ID

O00219

Protein name

Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3)

Protein function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13641	Glyco_tranf_2_3	154 → 360		Domain

Sequence

MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQS
LFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVM
VVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRA
STFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGG
VGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLE
DWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKS
YFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVG
IIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIG
LIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCG
KKPEQYSLAFAEV

Sequence length

553

Interactions

View interactions

	Reactome
			Hyaluronan biosynthesis and export

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	37247276
Carcinogenesis	Stimulate	25223521
Carcinogenesis	Inhibit	25934334
Carcinoma Basal Cell	Associate	26352698
Carcinoma Endometrioid	Associate	20875124
Cardiomyopathies	Associate	24470002, 26968791
Colorectal Neoplasms	Associate	22934709, 23922913
Death	Associate	26352698
Dermatitis Allergic Contact	Associate	35028126
Dermatitis Atopic	Associate	24658508, 31049964
Fibrosarcoma	Associate	36400790
Glioma	Associate	10794710
Hypoxia	Stimulate	21263749, 34521918
Lung Diseases	Associate	26352698
Melanoma	Associate	31820036
Melanoma Cutaneous Malignant	Associate	23560496
Mesothelioma	Associate	10794710
Mesothelioma Malignant	Associate	15161000
Multiple Myeloma	Stimulate	40481899
Neoplasm Metastasis	Associate	25934334
Neoplasms	Associate	20875124, 22934709, 25934334, 31820036
Ovarian Neoplasms	Associate	23202930
Prostatic Neoplasms Castration Resistant	Associate	37476073
Prostatitis	Associate	17502371, 21315068
Retinal Dysplasia	Associate	26352698
Squamous Cell Carcinoma of Head and Neck	Associate	36497040
Status Asthmaticus	Associate	30071849
Stomach Neoplasms	Associate	29693123
Urinary Bladder Neoplasms	Associate	25223521
Urologic Neoplasms	Associate	25934334

HAS3 (hyaluronan synthase 3)