CERS2 (ceramide synthase 2)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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29956 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Ceramide synthase 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CERS2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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L3, LASS2, SP260, TMSG1 |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q21.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growt |
miRNA
miRNA information provided by mirtarbase database.
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Transcription factors | ||||||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q96G23 | |||||||||||||||
Protein name | Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297) | |||||||||||||||
Protein function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:1972 | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed in kidney, liver, brain, heart, placenta and lung. {ECO:0000269|PubMed:11543633}. | |||||||||||||||
Sequence |
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Sequence length | 380 | |||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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