SEC61A1 (SEC61 translocon subunit alpha 1)
|
Gene
Gene information from NCBI Gene database.
|
|
| Entrez ID | 29927 |
| Gene name | SEC61 translocon subunit alpha 1 |
| Gene symbol | SEC61A1 |
| Synonyms (NCBI Gene) |
ADTKD5CVID15HNFJ4HSEC61SEC61SEC61A
|
| Chromosome | 3 |
| Chromosome location | 3q21.3 |
| Summary | The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-b |
|
SNPs
SNP information provided by dbSNP.
3
|
|||||||||||||||||
|
|||||||||||||||||
|
miRNA
miRNA information provided by mirtarbase database.
940
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
|
|||||||
|
|||||||
|
Protein
Protein information from UniProt database.
|
||||||||||||||||
|
UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
|
P61619 | |||||||||||||||
| Protein name | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | |||||||||||||||
| Protein function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:3 | |||||||||||||||
| PDB | 6W6L , 8B6L , 8DNV , 8DNW , 8DNX , 8DNY , 8DNZ , 8DO0 , 8DO1 , 8DO2 , 8DO3 | |||||||||||||||
| Family and domains |
Pfam
|
|||||||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Expressed in proximal and distal tubules in kidney (at protein level). {ECO:0000269|PubMed:28782633}. | |||||||||||||||
| Sequence | ||||||||||||||||
| Sequence length | 476 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
||||||||
|
||||||||
|
Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
45
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||