SEC61A1 (SEC61 translocon subunit alpha 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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29927 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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SEC61 translocon subunit alpha 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SEC61A1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A |
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Chromosome
Chromosome number
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3 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q21.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-b |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | P61619 | |||||||||||||||
| Protein name | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | |||||||||||||||
| Protein function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:3 | |||||||||||||||
| PDB | 6W6L , 8B6L , 8DNV , 8DNW , 8DNX , 8DNY , 8DNZ , 8DO0 , 8DO1 , 8DO2 , 8DO3 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in proximal and distal tubules in kidney (at protein level). {ECO:0000269|PubMed:28782633}. | |||||||||||||||
| Sequence | ||||||||||||||||
| Sequence length | 476 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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