Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29855
Gene name Gene Name - the full gene name approved by the HGNC.
Ubinuclein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UBN1
Synonyms (NCBI Gene) Gene synonyms aliases
VT, VT4
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs765004815 T>A Likely-pathogenic Genic downstream transcript variant, missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017200 hsa-miR-335-5p Microarray 18185580
MIRT048870 hsa-miR-93-5p CLASH 23622248
MIRT040978 hsa-miR-18a-3p CLASH 23622248
MIRT040198 hsa-miR-615-3p CLASH 23622248
MIRT651940 hsa-miR-499a-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 18823282, 19029251
GO:0005634 Component Nucleus IDA 10725330
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609771 12506 ENSG00000118900
Protein
UniProt ID Q9NPG3
Protein name Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)
Protein function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for rep
PDB 4ZBJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08729 HUN 117 168 HPC2 and ubinuclein domain Domain
PF14075 UBN_AB 353 573 Ubinuclein conserved middle domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}.
Sequence
MSEPHRVQFTSLPGSLNPAFLKKSRKEEAGAGEQHQDCEPAAAAVRITLTLFEPDHKRCP
EFFYPELVKNIRGKVKGLQPGDKKKDLSDPFNDEEKERHKVEALARKFEEKYGGKKRRKD
RIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQ
FRQASESEDDFI
KEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYS
GALSVKEMLKKFQKEKEAQKKREEEHKPVAVPSAEAQGLRELEGASDPLLSLFGSTSDND
LLQAATAMDSLTDLDLEHLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSLPEGLPAP
LEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPC
SKDALLKRARKLHLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLE
EEKDKEQRDRICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESQDLERNN
KAQAWEDCVKGFLDAEVKPLWPKGWMQARTLFK
ESRRGHGHLTSILAKKKVMAPSKIKVK
ESSTKPDKKVSVPSGQIGGPIALPSDHQTGGLSIGASSRELPSQASGGLANPPPVNLEDS
LDEDLIRNPASSVEAVSKELAALNSRAAGNSEFTLPAPSKAPAEKVGGVLCTEEKRNFAK
PSPSAPPPASSLQSPLNFLAEQALALGQSSQEKKPESSGYKELSCQAPLNKGLPEVHQSK
AKHHSLPRTSHGPQVAVPVPGPQVKVFHAGTQQQKNFTPPSPFANKLQGPKASPTQCHRS
LLQLVKTAAKGQGFHPSAPATSGGLSASSSSSHKTPASSSSALSHPAKPHSVSSAGSSYK
NNPFASSISKHGVSSGSSSSGGTPVQSSVSGSLVPGIQPPSVGQATSRPVPSSAGKKMPV
SQKLTLVAPPGGPNGDSSGGTQGVAKLLTSPSLKPSAVSSVTSSTSLSKGASGTVLLAGS
SLMASPYKSSSPKLSGAMSSNSLGIITPVPIPVHVLSFSADSSAKAGVSKDAIVTGPAPG
SFHHGLGHSLLAGLHSSPPHAAPLPHAAVPTHIPQSLPGASQLHGKGPAVPRKL
Sequence length 1134
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hydrops fetalis Hydrops Fetalis, Non-Immune rs28935477, rs1131691986 26036949
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Urinary Retention Associate 39222669