UBN1 (ubinuclein 1)

Gene

• Entrez ID: 29855
• Gene name: Ubinuclein 1
• Gene symbol: UBN1
• Synonyms (NCBI Gene): VT, VT4
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs765004815	T>A	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017200	hsa-miR-335-5p	Microarray	18185580
MIRT048870	hsa-miR-93-5p	CLASH	23622248
MIRT040978	hsa-miR-18a-3p	CLASH	23622248
MIRT040198	hsa-miR-615-3p	CLASH	23622248
MIRT651940	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT651938	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT651939	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT651937	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT651936	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT651935	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT651934	hsa-miR-3182	HITS-CLIP	23824327
MIRT651933	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT651932	hsa-miR-544a	HITS-CLIP	23824327
MIRT726194	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726193	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726192	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726190	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726191	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT651940	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT651938	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT651939	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT651937	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT651936	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT651935	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT651934	hsa-miR-3182	HITS-CLIP	23824327
MIRT651933	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT651932	hsa-miR-544a	HITS-CLIP	23824327
MIRT1470163	hsa-miR-1184	CLIP-seq
MIRT1470164	hsa-miR-128	CLIP-seq
MIRT1470165	hsa-miR-151-5p	CLIP-seq
MIRT1470166	hsa-miR-151b	CLIP-seq
MIRT1470167	hsa-miR-193a-3p	CLIP-seq
MIRT1470168	hsa-miR-193b	CLIP-seq
MIRT1470169	hsa-miR-217	CLIP-seq
MIRT1470170	hsa-miR-28-3p	CLIP-seq
MIRT1470171	hsa-miR-30a	CLIP-seq
MIRT1470172	hsa-miR-30b	CLIP-seq
MIRT1470173	hsa-miR-30c	CLIP-seq
MIRT1470174	hsa-miR-30d	CLIP-seq
MIRT1470175	hsa-miR-30e	CLIP-seq
MIRT1470176	hsa-miR-3150b-3p	CLIP-seq
MIRT1470177	hsa-miR-3180	CLIP-seq
MIRT1470178	hsa-miR-3180-3p	CLIP-seq
MIRT1470179	hsa-miR-3196	CLIP-seq
MIRT1470180	hsa-miR-34c-3p	CLIP-seq
MIRT1470181	hsa-miR-3607-3p	CLIP-seq
MIRT1470182	hsa-miR-3662	CLIP-seq
MIRT1470183	hsa-miR-3663-3p	CLIP-seq
MIRT1470184	hsa-miR-3664-5p	CLIP-seq
MIRT1470185	hsa-miR-3675-5p	CLIP-seq
MIRT1470186	hsa-miR-3686	CLIP-seq
MIRT1470187	hsa-miR-3691-3p	CLIP-seq
MIRT1470188	hsa-miR-3939	CLIP-seq
MIRT1470189	hsa-miR-4267	CLIP-seq
MIRT1470190	hsa-miR-4270	CLIP-seq
MIRT1470191	hsa-miR-4289	CLIP-seq
MIRT1470192	hsa-miR-4300	CLIP-seq
MIRT1470193	hsa-miR-4418	CLIP-seq
MIRT1470194	hsa-miR-4432	CLIP-seq
MIRT1470195	hsa-miR-4441	CLIP-seq
MIRT1470196	hsa-miR-4685-5p	CLIP-seq
MIRT1470197	hsa-miR-4714-5p	CLIP-seq
MIRT1470198	hsa-miR-4738-3p	CLIP-seq
MIRT1470199	hsa-miR-4778-5p	CLIP-seq
MIRT1470200	hsa-miR-4784	CLIP-seq
MIRT1470201	hsa-miR-495	CLIP-seq
MIRT1470202	hsa-miR-499-5p	CLIP-seq
MIRT1470203	hsa-miR-509-3-5p	CLIP-seq
MIRT1470204	hsa-miR-509-5p	CLIP-seq
MIRT1470205	hsa-miR-548c-3p	CLIP-seq
MIRT1470206	hsa-miR-591	CLIP-seq
MIRT1470207	hsa-miR-630	CLIP-seq
MIRT1470208	hsa-miR-766	CLIP-seq
MIRT1470209	hsa-miR-767-3p	CLIP-seq
MIRT1470210	hsa-miR-875-3p	CLIP-seq
MIRT1470211	hsa-miR-920	CLIP-seq
MIRT1470212	hsa-miR-1228	CLIP-seq
MIRT1470213	hsa-miR-1275	CLIP-seq
MIRT1470214	hsa-miR-15a	CLIP-seq
MIRT1470215	hsa-miR-15b	CLIP-seq
MIRT1470216	hsa-miR-16	CLIP-seq
MIRT1470217	hsa-miR-195	CLIP-seq
MIRT1470218	hsa-miR-19a	CLIP-seq
MIRT1470219	hsa-miR-19b	CLIP-seq
MIRT1470220	hsa-miR-219-2-3p	CLIP-seq
MIRT1470221	hsa-miR-2278	CLIP-seq
MIRT1470222	hsa-miR-2964a-3p	CLIP-seq
MIRT1470223	hsa-miR-302a	CLIP-seq
MIRT1470224	hsa-miR-302b	CLIP-seq
MIRT1470225	hsa-miR-302c	CLIP-seq
MIRT1470226	hsa-miR-302d	CLIP-seq
MIRT1470227	hsa-miR-302e	CLIP-seq
MIRT1470171	hsa-miR-30a	CLIP-seq
MIRT1470172	hsa-miR-30b	CLIP-seq
MIRT1470173	hsa-miR-30c	CLIP-seq
MIRT1470174	hsa-miR-30d	CLIP-seq
MIRT1470175	hsa-miR-30e	CLIP-seq
MIRT1470228	hsa-miR-3115	CLIP-seq
MIRT1470229	hsa-miR-342-3p	CLIP-seq
MIRT1470230	hsa-miR-3591-3p	CLIP-seq
MIRT1470181	hsa-miR-3607-3p	CLIP-seq
MIRT1470231	hsa-miR-3613-3p	CLIP-seq
MIRT1470184	hsa-miR-3664-5p	CLIP-seq
MIRT1470186	hsa-miR-3686	CLIP-seq
MIRT1470187	hsa-miR-3691-3p	CLIP-seq
MIRT1470232	hsa-miR-372	CLIP-seq
MIRT1470233	hsa-miR-373	CLIP-seq
MIRT1470234	hsa-miR-380	CLIP-seq
MIRT1470235	hsa-miR-3919	CLIP-seq
MIRT1470188	hsa-miR-3939	CLIP-seq
MIRT1470236	hsa-miR-424	CLIP-seq
MIRT1470237	hsa-miR-4260	CLIP-seq
MIRT1470189	hsa-miR-4267	CLIP-seq
MIRT1470238	hsa-miR-4428	CLIP-seq
MIRT1470194	hsa-miR-4432	CLIP-seq
MIRT1470239	hsa-miR-4436a	CLIP-seq
MIRT1470240	hsa-miR-4452	CLIP-seq
MIRT1470241	hsa-miR-4468	CLIP-seq
MIRT1470242	hsa-miR-4488	CLIP-seq
MIRT1470243	hsa-miR-4495	CLIP-seq
MIRT1470244	hsa-miR-4665-5p	CLIP-seq
MIRT1470245	hsa-miR-4684-3p	CLIP-seq
MIRT1470246	hsa-miR-4691-5p	CLIP-seq
MIRT1470247	hsa-miR-4697-5p	CLIP-seq
MIRT1470197	hsa-miR-4714-5p	CLIP-seq
MIRT1470248	hsa-miR-4749-3p	CLIP-seq
MIRT739598	hsa-miR-486-3p	CLIP-seq
MIRT1470249	hsa-miR-494	CLIP-seq
MIRT1470201	hsa-miR-495	CLIP-seq
MIRT1470250	hsa-miR-497	CLIP-seq
MIRT1470202	hsa-miR-499-5p	CLIP-seq
MIRT1470251	hsa-miR-518a-5p	CLIP-seq
MIRT1470252	hsa-miR-519a	CLIP-seq
MIRT1470253	hsa-miR-519b-3p	CLIP-seq
MIRT1470254	hsa-miR-519c-3p	CLIP-seq
MIRT1470255	hsa-miR-520a-3p	CLIP-seq
MIRT1470256	hsa-miR-520b	CLIP-seq
MIRT1470257	hsa-miR-520c-3p	CLIP-seq
MIRT1470258	hsa-miR-520d-3p	CLIP-seq
MIRT1470259	hsa-miR-520e	CLIP-seq
MIRT1470260	hsa-miR-527	CLIP-seq
MIRT1470261	hsa-miR-553	CLIP-seq
MIRT1470262	hsa-miR-554	CLIP-seq
MIRT1470263	hsa-miR-609	CLIP-seq
MIRT739597	hsa-miR-622	CLIP-seq
MIRT1470208	hsa-miR-766	CLIP-seq
MIRT1470210	hsa-miR-875-3p	CLIP-seq
MIRT1470264	hsa-miR-922	CLIP-seq
MIRT739598	hsa-miR-486-3p	CLIP-seq
MIRT1555329	hsa-miR-544b	CLIP-seq
MIRT739597	hsa-miR-622	CLIP-seq
MIRT1470163	hsa-miR-1184	CLIP-seq
MIRT2141562	hsa-miR-1205	CLIP-seq
MIRT2141563	hsa-miR-125a-5p	CLIP-seq
MIRT2141564	hsa-miR-125b	CLIP-seq
MIRT1470164	hsa-miR-128	CLIP-seq
MIRT2141565	hsa-miR-1298	CLIP-seq
MIRT2141566	hsa-miR-143	CLIP-seq
MIRT1470165	hsa-miR-151-5p	CLIP-seq
MIRT1470166	hsa-miR-151b	CLIP-seq
MIRT2141567	hsa-miR-1827	CLIP-seq
MIRT1470167	hsa-miR-193a-3p	CLIP-seq
MIRT1470168	hsa-miR-193b	CLIP-seq
MIRT1470218	hsa-miR-19a	CLIP-seq
MIRT1470219	hsa-miR-19b	CLIP-seq
MIRT2141568	hsa-miR-2116	CLIP-seq
MIRT1470169	hsa-miR-217	CLIP-seq
MIRT1470170	hsa-miR-28-3p	CLIP-seq
MIRT2141569	hsa-miR-28-5p	CLIP-seq
MIRT2141570	hsa-miR-300	CLIP-seq
MIRT2141571	hsa-miR-31	CLIP-seq
MIRT2141572	hsa-miR-3139	CLIP-seq
MIRT1470176	hsa-miR-3150b-3p	CLIP-seq
MIRT2141573	hsa-miR-3153	CLIP-seq
MIRT2141574	hsa-miR-3158-5p	CLIP-seq
MIRT2141575	hsa-miR-3164	CLIP-seq
MIRT2141576	hsa-miR-3194-3p	CLIP-seq
MIRT2141577	hsa-miR-346	CLIP-seq
MIRT1470180	hsa-miR-34c-3p	CLIP-seq
MIRT2141578	hsa-miR-362-5p	CLIP-seq
MIRT1470183	hsa-miR-3663-3p	CLIP-seq
MIRT2141579	hsa-miR-371b-3p	CLIP-seq
MIRT2141580	hsa-miR-381	CLIP-seq
MIRT1470235	hsa-miR-3919	CLIP-seq
MIRT2141581	hsa-miR-3921	CLIP-seq
MIRT2141582	hsa-miR-3934	CLIP-seq
MIRT2141583	hsa-miR-4252	CLIP-seq
MIRT2141584	hsa-miR-4266	CLIP-seq
MIRT2141585	hsa-miR-4290	CLIP-seq
MIRT2141586	hsa-miR-4312	CLIP-seq
MIRT2141587	hsa-miR-4319	CLIP-seq
MIRT1470193	hsa-miR-4418	CLIP-seq
MIRT1470239	hsa-miR-4436a	CLIP-seq
MIRT2141588	hsa-miR-4446-5p	CLIP-seq
MIRT2141589	hsa-miR-4457	CLIP-seq
MIRT2141590	hsa-miR-4474-5p	CLIP-seq
MIRT2141591	hsa-miR-4481	CLIP-seq
MIRT2141592	hsa-miR-4486	CLIP-seq
MIRT2141593	hsa-miR-4493	CLIP-seq
MIRT2141594	hsa-miR-4527	CLIP-seq
MIRT2141595	hsa-miR-455-3p	CLIP-seq
MIRT2141596	hsa-miR-4649-3p	CLIP-seq
MIRT2141597	hsa-miR-4653-5p	CLIP-seq
MIRT2141598	hsa-miR-4658	CLIP-seq
MIRT2141599	hsa-miR-4659a-5p	CLIP-seq
MIRT2141600	hsa-miR-4659b-5p	CLIP-seq
MIRT2141601	hsa-miR-4666-3p	CLIP-seq
MIRT2141602	hsa-miR-4668-5p	CLIP-seq
MIRT2141603	hsa-miR-4677-5p	CLIP-seq
MIRT2141604	hsa-miR-4687-3p	CLIP-seq
MIRT2141605	hsa-miR-4691-3p	CLIP-seq
MIRT2141606	hsa-miR-4704-3p	CLIP-seq
MIRT2141607	hsa-miR-4725-5p	CLIP-seq
MIRT2141608	hsa-miR-4732-3p	CLIP-seq
MIRT1470198	hsa-miR-4738-3p	CLIP-seq
MIRT2141609	hsa-miR-4742-5p	CLIP-seq
MIRT2141610	hsa-miR-4745-5p	CLIP-seq
MIRT2141611	hsa-miR-4747-5p	CLIP-seq
MIRT2141612	hsa-miR-4753-5p	CLIP-seq
MIRT2141613	hsa-miR-4755-5p	CLIP-seq
MIRT2141614	hsa-miR-4756-3p	CLIP-seq
MIRT2141615	hsa-miR-4758-5p	CLIP-seq
MIRT2141616	hsa-miR-4762-5p	CLIP-seq
MIRT2141617	hsa-miR-4770	CLIP-seq
MIRT2141618	hsa-miR-4776-3p	CLIP-seq
MIRT1470200	hsa-miR-4784	CLIP-seq
MIRT739598	hsa-miR-486-3p	CLIP-seq
MIRT1470249	hsa-miR-494	CLIP-seq
MIRT2141619	hsa-miR-500a	CLIP-seq
MIRT2141620	hsa-miR-500b	CLIP-seq
MIRT2141621	hsa-miR-504	CLIP-seq
MIRT1470203	hsa-miR-509-3-5p	CLIP-seq
MIRT1470204	hsa-miR-509-5p	CLIP-seq
MIRT2141622	hsa-miR-513b	CLIP-seq
MIRT1555329	hsa-miR-544b	CLIP-seq
MIRT2141623	hsa-miR-545	CLIP-seq
MIRT1470205	hsa-miR-548c-3p	CLIP-seq
MIRT1470262	hsa-miR-554	CLIP-seq
MIRT2141624	hsa-miR-563	CLIP-seq
MIRT739597	hsa-miR-622	CLIP-seq
MIRT2141625	hsa-miR-640	CLIP-seq
MIRT2141626	hsa-miR-670	CLIP-seq
MIRT2141627	hsa-miR-676	CLIP-seq
MIRT2141628	hsa-miR-708	CLIP-seq
MIRT2141629	hsa-miR-760	CLIP-seq
MIRT1470209	hsa-miR-767-3p	CLIP-seq
MIRT1470163	hsa-miR-1184	CLIP-seq
MIRT2141562	hsa-miR-1205	CLIP-seq
MIRT2362357	hsa-miR-1236	CLIP-seq
MIRT2141563	hsa-miR-125a-5p	CLIP-seq
MIRT2141564	hsa-miR-125b	CLIP-seq
MIRT1470213	hsa-miR-1275	CLIP-seq
MIRT1470214	hsa-miR-15a	CLIP-seq
MIRT1470215	hsa-miR-15b	CLIP-seq
MIRT1470216	hsa-miR-16	CLIP-seq
MIRT2141567	hsa-miR-1827	CLIP-seq
MIRT1470217	hsa-miR-195	CLIP-seq
MIRT2141568	hsa-miR-2116	CLIP-seq
MIRT1470170	hsa-miR-28-3p	CLIP-seq
MIRT2141569	hsa-miR-28-5p	CLIP-seq
MIRT2141571	hsa-miR-31	CLIP-seq
MIRT2141572	hsa-miR-3139	CLIP-seq
MIRT2141574	hsa-miR-3158-5p	CLIP-seq
MIRT2141575	hsa-miR-3164	CLIP-seq
MIRT2362358	hsa-miR-3174	CLIP-seq
MIRT2141576	hsa-miR-3194-3p	CLIP-seq
MIRT1470180	hsa-miR-34c-3p	CLIP-seq
MIRT1470230	hsa-miR-3591-3p	CLIP-seq
MIRT1470182	hsa-miR-3662	CLIP-seq
MIRT1470183	hsa-miR-3663-3p	CLIP-seq
MIRT2362359	hsa-miR-3673	CLIP-seq
MIRT2141579	hsa-miR-371b-3p	CLIP-seq
MIRT2141582	hsa-miR-3934	CLIP-seq
MIRT1470236	hsa-miR-424	CLIP-seq
MIRT2141583	hsa-miR-4252	CLIP-seq
MIRT1470237	hsa-miR-4260	CLIP-seq
MIRT2141584	hsa-miR-4266	CLIP-seq
MIRT2141585	hsa-miR-4290	CLIP-seq
MIRT1470192	hsa-miR-4300	CLIP-seq
MIRT2141587	hsa-miR-4319	CLIP-seq
MIRT1470239	hsa-miR-4436a	CLIP-seq
MIRT2141588	hsa-miR-4446-5p	CLIP-seq
MIRT2141589	hsa-miR-4457	CLIP-seq
MIRT2141591	hsa-miR-4481	CLIP-seq
MIRT1470242	hsa-miR-4488	CLIP-seq
MIRT2141596	hsa-miR-4649-3p	CLIP-seq
MIRT2141598	hsa-miR-4658	CLIP-seq
MIRT1470244	hsa-miR-4665-5p	CLIP-seq
MIRT2141605	hsa-miR-4691-3p	CLIP-seq
MIRT1470247	hsa-miR-4697-5p	CLIP-seq
MIRT2141608	hsa-miR-4732-3p	CLIP-seq
MIRT2141609	hsa-miR-4742-5p	CLIP-seq
MIRT2141610	hsa-miR-4745-5p	CLIP-seq
MIRT2141613	hsa-miR-4755-5p	CLIP-seq
MIRT2141615	hsa-miR-4758-5p	CLIP-seq
MIRT2141616	hsa-miR-4762-5p	CLIP-seq
MIRT1470199	hsa-miR-4778-5p	CLIP-seq
MIRT739598	hsa-miR-486-3p	CLIP-seq
MIRT1470249	hsa-miR-494	CLIP-seq
MIRT1470201	hsa-miR-495	CLIP-seq
MIRT1470250	hsa-miR-497	CLIP-seq
MIRT2141619	hsa-miR-500a	CLIP-seq
MIRT2141622	hsa-miR-513b	CLIP-seq
MIRT1555329	hsa-miR-544b	CLIP-seq
MIRT1470205	hsa-miR-548c-3p	CLIP-seq
MIRT2362360	hsa-miR-552	CLIP-seq
MIRT1470262	hsa-miR-554	CLIP-seq
MIRT2141624	hsa-miR-563	CLIP-seq
MIRT739597	hsa-miR-622	CLIP-seq
MIRT1470207	hsa-miR-630	CLIP-seq
MIRT2362361	hsa-miR-661	CLIP-seq
MIRT2141626	hsa-miR-670	CLIP-seq
MIRT2141628	hsa-miR-708	CLIP-seq
MIRT2141629	hsa-miR-760	CLIP-seq
MIRT1470209	hsa-miR-767-3p	CLIP-seq
MIRT1470211	hsa-miR-920	CLIP-seq
MIRT1470264	hsa-miR-922	CLIP-seq
MIRT2396604	hsa-miR-1225-3p	CLIP-seq
MIRT2141563	hsa-miR-125a-5p	CLIP-seq
MIRT2141564	hsa-miR-125b	CLIP-seq
MIRT2141587	hsa-miR-4319	CLIP-seq
MIRT1470241	hsa-miR-4468	CLIP-seq
MIRT1470163	hsa-miR-1184	CLIP-seq
MIRT2396604	hsa-miR-1225-3p	CLIP-seq
MIRT2141563	hsa-miR-125a-5p	CLIP-seq
MIRT2141564	hsa-miR-125b	CLIP-seq
MIRT1470169	hsa-miR-217	CLIP-seq
MIRT1470190	hsa-miR-4270	CLIP-seq
MIRT1470192	hsa-miR-4300	CLIP-seq
MIRT2141587	hsa-miR-4319	CLIP-seq
MIRT1470193	hsa-miR-4418	CLIP-seq
MIRT1470195	hsa-miR-4441	CLIP-seq
MIRT1470241	hsa-miR-4468	CLIP-seq
MIRT2656226	hsa-miR-4519	CLIP-seq
MIRT1470196	hsa-miR-4685-5p	CLIP-seq
MIRT1470203	hsa-miR-509-3-5p	CLIP-seq
MIRT1470204	hsa-miR-509-5p	CLIP-seq
MIRT1470206	hsa-miR-591	CLIP-seq
MIRT1470211	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	18823282, 19029251, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10725330
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0006325	Process	Chromatin organization	IBA
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IDA	14718166
GO:0016604	Component	Nuclear body	IDA
GO:0016605	Component	PML body	IEA
GO:0034451	Component	Centriolar satellite	IDA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 609771
• HGNC: 12506
• e!Ensembl: ENSG00000118900

Protein

• UniProt ID: Q9NPG3
• Protein name: Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)
• Protein function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for rep
• PDB: 4ZBJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08729	HUN	117 → 168	HPC2 and ubinuclein domain	Domain
  PF14075	UBN_AB	353 → 573	Ubinuclein conserved middle domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:19029251}.
• Sequence:

  MSEPHRVQFTSLPGSLNPAFLKKSRKEEAGAGEQHQDCEPAAAAVRITLTLFEPDHKRCP
  EFFYPELVKNIRGKVKGLQPGDKKKDLSDPFNDEEKERHKVEALARKFEEKYGGKKRRKD
  RIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFI
  KEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYS
  GALSVKEMLKKFQKEKEAQKKREEEHKPVAVPSAEAQGLRELEGASDPLLSLFGSTSDND
  LLQAATAMDSLTDLDLEHLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSLPEGLPAP
  LEKRVKELAQAARAAEGESRQKFFTQDINGILLDIEAQTRELSSQVRSGVYAYLASFLPC
  SKDALLKRARKLHLYEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLE
  EEKDKEQRDRICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESQDLERNN
  KAQAWEDCVKGFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSILAKKKVMAPSKIKVK
  ESSTKPDKKVSVPSGQIGGPIALPSDHQTGGLSIGASSRELPSQASGGLANPPPVNLEDS
  LDEDLIRNPASSVEAVSKELAALNSRAAGNSEFTLPAPSKAPAEKVGGVLCTEEKRNFAK
  PSPSAPPPASSLQSPLNFLAEQALALGQSSQEKKPESSGYKELSCQAPLNKGLPEVHQSK
  AKHHSLPRTSHGPQVAVPVPGPQVKVFHAGTQQQKNFTPPSPFANKLQGPKASPTQCHRS
  LLQLVKTAAKGQGFHPSAPATSGGLSASSSSSHKTPASSSSALSHPAKPHSVSSAGSSYK
  NNPFASSISKHGVSSGSSSSGGTPVQSSVSGSLVPGIQPPSVGQATSRPVPSSAGKKMPV
  SQKLTLVAPPGGPNGDSSGGTQGVAKLLTSPSLKPSAVSSVTSSTSLSKGASGTVLLAGS
  SLMASPYKSSSPKLSGAMSSNSLGIITPVPIPVHVLSFSADSSAKAGVSKDAIVTGPAPG
  SFHHGLGHSLLAGLHSSPPHAAPLPHAAVPTHIPQSLPGASQLHGKGPAVPRKL

• Sequence length: 1134

Pathways

Reactome:

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Non-immune hydrops fetalis	Likely pathogenic	rs765004815	RCV000170572

Associations from Text Mining
Disease Name	Relationship Type	References
Urinary Retention	Associate	39222669