Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29789
Gene name Gene Name - the full gene name approved by the HGNC.
Obg like ATPase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OLA1
Synonyms (NCBI Gene) Gene synonyms aliases
DOC45, GBP45, GTBP9, GTPBP9, PTD004
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050153 hsa-miR-26a-5p CLASH 23622248
MIRT046736 hsa-miR-222-3p CLASH 23622248
MIRT036907 hsa-miR-877-3p CLASH 23622248
MIRT695716 hsa-miR-4517 HITS-CLIP 23313552
MIRT695715 hsa-miR-5583-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0005515 Function Protein binding IPI 22190034
GO:0005524 Function ATP binding IDA 17430889
GO:0005525 Function GTP binding IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611175 28833 ENSG00000138430
Protein
UniProt ID Q9NTK5
Protein name Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)
Protein function Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
PDB 2OHF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01926 MMR_HSR1 24 231 50S ribosome-binding GTPase Family
PF06071 YchF-GTPase_C 305 388 Protein of unknown function (DUF933) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
Sequence
Sequence length 396
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
20852631
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Schizophrenia Schizophrenia GWAS
Astrocytoma Astrocytoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26863455
Atherosclerosis Associate 36232807
Breast Neoplasms Associate 19882753, 24289923
Carcinogenesis Associate 20053727, 35440019
Carcinoma Hepatocellular Associate 35854246
Colorectal Neoplasms Associate 20053727, 34743750, 35440019
Hypoxia Brain Associate 35440019
Lung Neoplasms Associate 26863455
Lymphatic Metastasis Associate 26863455
Lymphatic Metastasis Stimulate 37306352