Gene Gene information from NCBI Gene database.
Entrez ID 29789
Gene name Obg like ATPase 1
Gene symbol OLA1
Synonyms (NCBI Gene)
DOC45GBP45GTBP9GTPBP9PTD004
Chromosome 2
Chromosome location 2q31.1
Summary This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has
miRNA miRNA information provided by mirtarbase database.
309
miRTarBase ID miRNA Experiments Reference
MIRT050153 hsa-miR-26a-5p CLASH 23622248
MIRT046736 hsa-miR-222-3p CLASH 23622248
MIRT036907 hsa-miR-877-3p CLASH 23622248
MIRT695716 hsa-miR-4517 HITS-CLIP 23313552
MIRT695715 hsa-miR-5583-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 22190034
GO:0005524 Function ATP binding IDA 17430889
GO:0005524 Function ATP binding IEA
GO:0005525 Function GTP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611175 28833 ENSG00000138430
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NTK5
Protein name Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)
Protein function Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
PDB 2OHF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01926 MMR_HSR1 24 231 50S ribosome-binding GTPase Family
PF06071 YchF-GTPase_C 305 388 Protein of unknown function (DUF933) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
Sequence
Sequence length 396
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920787 RCV000149026
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26863455
Atherosclerosis Associate 36232807
Breast Neoplasms Associate 19882753, 24289923
Carcinogenesis Associate 20053727, 35440019
Carcinoma Hepatocellular Associate 35854246
Colorectal Neoplasms Associate 20053727, 34743750, 35440019
Hypoxia Brain Associate 35440019
Lung Neoplasms Associate 26863455
Lymphatic Metastasis Associate 26863455
Lymphatic Metastasis Stimulate 37306352