Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2941
Gene name Gene Name - the full gene name approved by the HGNC.	Glutathione S-transferase alpha 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GSTA4
Synonyms (NCBI Gene) Gene synonyms aliases	GSTA4-4, GTA4
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p12.2
Summary Summary of gene provided in NCBI Entrez Gene.	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, e

Show/Hide all(127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045335	hsa-miR-185-5p	CLASH	23622248
MIRT1036474	hsa-miR-1243	CLIP-seq
MIRT1036475	hsa-miR-342-3p	CLIP-seq
MIRT1036476	hsa-miR-3613-3p	CLIP-seq
MIRT1036477	hsa-miR-3654	CLIP-seq
MIRT1036478	hsa-miR-377	CLIP-seq
MIRT1036479	hsa-miR-4638-3p	CLIP-seq
MIRT1036480	hsa-miR-4643	CLIP-seq
MIRT1036481	hsa-miR-4699-3p	CLIP-seq
MIRT1036482	hsa-miR-4717-3p	CLIP-seq
MIRT1036483	hsa-miR-4764-5p	CLIP-seq
MIRT1036484	hsa-miR-4802-3p	CLIP-seq
MIRT1036485	hsa-miR-490-5p	CLIP-seq
MIRT1036486	hsa-miR-668	CLIP-seq
MIRT1036487	hsa-miR-944	CLIP-seq
MIRT1549407	hsa-miR-28-3p	CLIP-seq
MIRT1549408	hsa-miR-3150b-3p	CLIP-seq
MIRT1549409	hsa-miR-4257	CLIP-seq
MIRT1549410	hsa-miR-4305	CLIP-seq
MIRT1036481	hsa-miR-4699-3p	CLIP-seq
MIRT1549411	hsa-miR-4729	CLIP-seq
MIRT1549412	hsa-miR-4784	CLIP-seq
MIRT1549408	hsa-miR-3150b-3p	CLIP-seq
MIRT2239916	hsa-miR-33a	CLIP-seq
MIRT2239917	hsa-miR-33b	CLIP-seq
MIRT1549409	hsa-miR-4257	CLIP-seq
MIRT1549412	hsa-miR-4784	CLIP-seq
MIRT2239918	hsa-miR-556-3p	CLIP-seq
MIRT2239919	hsa-miR-664	CLIP-seq
MIRT2388798	hsa-miR-3117-3p	CLIP-seq
MIRT2388799	hsa-miR-374c	CLIP-seq
MIRT2388800	hsa-miR-376c	CLIP-seq
MIRT2388801	hsa-miR-655	CLIP-seq
MIRT2388802	hsa-miR-711	CLIP-seq
MIRT2543452	hsa-miR-1183	CLIP-seq
MIRT2543453	hsa-miR-1251	CLIP-seq
MIRT2543454	hsa-miR-200b	CLIP-seq
MIRT2543455	hsa-miR-200c	CLIP-seq
MIRT2543456	hsa-miR-208a	CLIP-seq
MIRT2543457	hsa-miR-208b	CLIP-seq
MIRT2543458	hsa-miR-2682	CLIP-seq
MIRT1549407	hsa-miR-28-3p	CLIP-seq
MIRT2543459	hsa-miR-29a	CLIP-seq
MIRT2543460	hsa-miR-29b	CLIP-seq
MIRT2543461	hsa-miR-29c	CLIP-seq
MIRT2388798	hsa-miR-3117-3p	CLIP-seq
MIRT1549408	hsa-miR-3150b-3p	CLIP-seq
MIRT2239916	hsa-miR-33a	CLIP-seq
MIRT2239917	hsa-miR-33b	CLIP-seq
MIRT2543462	hsa-miR-3617	CLIP-seq
MIRT2543463	hsa-miR-3667-5p	CLIP-seq
MIRT2543464	hsa-miR-3675-3p	CLIP-seq
MIRT2388799	hsa-miR-374c	CLIP-seq
MIRT2388800	hsa-miR-376c	CLIP-seq
MIRT2543465	hsa-miR-3914	CLIP-seq
MIRT1549409	hsa-miR-4257	CLIP-seq
MIRT2543466	hsa-miR-429	CLIP-seq
MIRT1549410	hsa-miR-4305	CLIP-seq
MIRT2543467	hsa-miR-4423-3p	CLIP-seq
MIRT2543468	hsa-miR-4463	CLIP-seq
MIRT2543469	hsa-miR-4477a	CLIP-seq
MIRT2543470	hsa-miR-4487	CLIP-seq
MIRT2543471	hsa-miR-449c	CLIP-seq
MIRT2543472	hsa-miR-450b-3p	CLIP-seq
MIRT1036481	hsa-miR-4699-3p	CLIP-seq
MIRT2543473	hsa-miR-4713-3p	CLIP-seq
MIRT1549411	hsa-miR-4729	CLIP-seq
MIRT1549412	hsa-miR-4784	CLIP-seq
MIRT2543474	hsa-miR-499-5p	CLIP-seq
MIRT2543475	hsa-miR-548c-3p	CLIP-seq
MIRT2239918	hsa-miR-556-3p	CLIP-seq
MIRT2543476	hsa-miR-603	CLIP-seq
MIRT2543477	hsa-miR-638	CLIP-seq
MIRT2543478	hsa-miR-641	CLIP-seq
MIRT2543479	hsa-miR-642b	CLIP-seq
MIRT2388801	hsa-miR-655	CLIP-seq
MIRT2239919	hsa-miR-664	CLIP-seq
MIRT1036486	hsa-miR-668	CLIP-seq
MIRT2388802	hsa-miR-711	CLIP-seq
MIRT2543480	hsa-miR-767-5p	CLIP-seq
MIRT2543481	hsa-miR-769-3p	CLIP-seq
MIRT2543482	hsa-miR-885-5p	CLIP-seq
MIRT2543483	hsa-miR-940	CLIP-seq
MIRT2543484	hsa-miR-943	CLIP-seq
MIRT2543452	hsa-miR-1183	CLIP-seq
MIRT2543453	hsa-miR-1251	CLIP-seq
MIRT2543454	hsa-miR-200b	CLIP-seq
MIRT2543455	hsa-miR-200c	CLIP-seq
MIRT2543456	hsa-miR-208a	CLIP-seq
MIRT2543457	hsa-miR-208b	CLIP-seq
MIRT1549407	hsa-miR-28-3p	CLIP-seq
MIRT2543459	hsa-miR-29a	CLIP-seq
MIRT2543460	hsa-miR-29b	CLIP-seq
MIRT2543461	hsa-miR-29c	CLIP-seq
MIRT2388798	hsa-miR-3117-3p	CLIP-seq
MIRT1549408	hsa-miR-3150b-3p	CLIP-seq
MIRT2239916	hsa-miR-33a	CLIP-seq
MIRT2239917	hsa-miR-33b	CLIP-seq
MIRT2543462	hsa-miR-3617	CLIP-seq
MIRT2543463	hsa-miR-3667-5p	CLIP-seq
MIRT2543464	hsa-miR-3675-3p	CLIP-seq
MIRT2388799	hsa-miR-374c	CLIP-seq
MIRT2388800	hsa-miR-376c	CLIP-seq
MIRT2543465	hsa-miR-3914	CLIP-seq
MIRT1549409	hsa-miR-4257	CLIP-seq
MIRT2543466	hsa-miR-429	CLIP-seq
MIRT1549410	hsa-miR-4305	CLIP-seq
MIRT2543469	hsa-miR-4477a	CLIP-seq
MIRT2543470	hsa-miR-4487	CLIP-seq
MIRT2543472	hsa-miR-450b-3p	CLIP-seq
MIRT1036481	hsa-miR-4699-3p	CLIP-seq
MIRT2543473	hsa-miR-4713-3p	CLIP-seq
MIRT1549411	hsa-miR-4729	CLIP-seq
MIRT1549412	hsa-miR-4784	CLIP-seq
MIRT2543474	hsa-miR-499-5p	CLIP-seq
MIRT2239918	hsa-miR-556-3p	CLIP-seq
MIRT2543476	hsa-miR-603	CLIP-seq
MIRT2543477	hsa-miR-638	CLIP-seq
MIRT2543478	hsa-miR-641	CLIP-seq
MIRT2543479	hsa-miR-642b	CLIP-seq
MIRT2388801	hsa-miR-655	CLIP-seq
MIRT2239919	hsa-miR-664	CLIP-seq
MIRT2388802	hsa-miR-711	CLIP-seq
MIRT2543480	hsa-miR-767-5p	CLIP-seq
MIRT2543481	hsa-miR-769-3p	CLIP-seq
MIRT2543482	hsa-miR-885-5p	CLIP-seq
MIRT2543484	hsa-miR-943	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IBA	21873635
GO:0004364	Function	Glutathione transferase activity	IDA	10329152, 11851347
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 28514442, 31515488, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0006749	Process	Glutathione metabolic process	IBA	21873635
GO:0006749	Process	Glutathione metabolic process	IDA	10329152
GO:0006805	Process	Xenobiotic metabolic process	IBA	21873635
GO:0006805	Process	Xenobiotic metabolic process	IDA	10329152
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 32296183
GO:0042803	Function	Protein homodimerization activity	IPI	10329152
GO:1901687	Process	Glutathione derivative biosynthetic process	TAS

MIM	HGNC	e!Ensembl
605450	4629	ENSG00000170899

Protein

UniProt ID

O15217

Protein name

Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4)

Protein function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:00

PDB

1GUL , 1GUM , 3IK7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02798	GST_N	5 → 77	Glutathione S-transferase, N-terminal domain	Domain
PF14497	GST_C_3	100 → 201	Glutathione S-transferase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.

Sequence

MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP

Sequence length

222

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis		Glutathione conjugation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	16510128

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Atherosclerosis	Associate	18485437, 9461507
Azoospermia	Associate	36945018
Cataract	Associate	9461507
Cholangitis Sclerosing	Associate	29180269
Cholestasis	Inhibit	25798860
Colitis Ulcerative	Stimulate	29941222
DNA Virus Infections	Associate	18096195
Drug Related Side Effects and Adverse Reactions	Associate	18782442, 9461507
Epilepsy	Associate	23962720
Inflammatory Bowel Diseases	Inhibit	29180269
Liver Diseases Alcoholic	Stimulate	26518673
Melanoma	Associate	36162957
Migraine Disorders	Associate	35546551
Neoplasm Metastasis	Associate	36162957
Neoplasms	Associate	36162957
Parkinson Disease	Associate	9461507

GSTA4 (glutathione S-transferase alpha 4)