Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2916
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate metabotropic receptor 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRM6
Synonyms (NCBI Gene) Gene synonyms aliases	CSNB1B, GPRC1F, MGLUR6, mGlu6
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CSNB1B
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q35.3
Summary Summary of gene provided in NCBI Entrez Gene.	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

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SNP ID	Visualize variation	Clinical significance	Consequence
rs62638197	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs62638202	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs62638208	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs62638214	G>A	Pathogenic	Coding sequence variant, stop gained
rs62638619	C>A,T	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs62638624	G>A,T	Not-provided, pathogenic	Coding sequence variant, stop gained, missense variant
rs62638625	C>T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs79602188	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs121434304	A>G,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs748979061	G>A	Pathogenic	Coding sequence variant, stop gained
rs756171835	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs781463257	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1237461749	AGCGTCAGGCCGCCC>-,AGCGTCAGGCCGCCCAGCGTCAGGCCGCCC	Likely-pathogenic	Inframe deletion, coding sequence variant, inframe insertion

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miRTarBase ID	miRNA	Experiments	Reference
MIRT677772	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677771	hsa-miR-4438	HITS-CLIP	23824327
MIRT677770	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT677769	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677768	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677767	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677766	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677764	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677763	hsa-miR-1976	HITS-CLIP	23824327
MIRT677762	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT677761	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT677760	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677759	hsa-miR-5095	HITS-CLIP	23824327
MIRT677758	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT677757	hsa-miR-4279	HITS-CLIP	23824327
MIRT677756	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	PAR-CLIP	27292025
MIRT677763	hsa-miR-1976	PAR-CLIP	27292025
MIRT677764	hsa-miR-3653-5p	PAR-CLIP	27292025
MIRT677757	hsa-miR-4279	PAR-CLIP	27292025
MIRT677768	hsa-miR-4722-3p	PAR-CLIP	27292025
MIRT677772	hsa-miR-582-3p	PAR-CLIP	27292025
MIRT677767	hsa-miR-6727-3p	PAR-CLIP	27292025
MIRT677766	hsa-miR-6747-3p	PAR-CLIP	27292025
MIRT677760	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT677769	hsa-miR-6814-5p	PAR-CLIP	27292025
MIRT677772	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677771	hsa-miR-4438	HITS-CLIP	23824327
MIRT677770	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT677769	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677768	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677767	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677766	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677765	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677764	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677763	hsa-miR-1976	HITS-CLIP	23824327
MIRT677762	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT677761	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT677760	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677759	hsa-miR-5095	HITS-CLIP	23824327
MIRT677758	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT677757	hsa-miR-4279	HITS-CLIP	23824327
MIRT677756	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT1035201	hsa-miR-101	CLIP-seq
MIRT1035202	hsa-miR-105	CLIP-seq
MIRT1035203	hsa-miR-1254	CLIP-seq
MIRT1035204	hsa-miR-1256	CLIP-seq
MIRT1035205	hsa-miR-1286	CLIP-seq
MIRT1035206	hsa-miR-144	CLIP-seq
MIRT1035207	hsa-miR-1827	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT1035210	hsa-miR-197	CLIP-seq
MIRT1035211	hsa-miR-2054	CLIP-seq
MIRT1035212	hsa-miR-3116	CLIP-seq
MIRT1035213	hsa-miR-3120-3p	CLIP-seq
MIRT1035214	hsa-miR-3122	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035217	hsa-miR-3153	CLIP-seq
MIRT1035218	hsa-miR-3163	CLIP-seq
MIRT1035219	hsa-miR-3170	CLIP-seq
MIRT1035220	hsa-miR-3187-3p	CLIP-seq
MIRT1035221	hsa-miR-342-5p	CLIP-seq
MIRT1035222	hsa-miR-3612	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035224	hsa-miR-3663-5p	CLIP-seq
MIRT1035225	hsa-miR-3667-5p	CLIP-seq
MIRT1035226	hsa-miR-3687	CLIP-seq
MIRT1035227	hsa-miR-3689a-3p	CLIP-seq
MIRT1035228	hsa-miR-3689c	CLIP-seq
MIRT1035229	hsa-miR-3689d	CLIP-seq
MIRT1035230	hsa-miR-380	CLIP-seq
MIRT1035231	hsa-miR-3908	CLIP-seq
MIRT1035232	hsa-miR-3913-5p	CLIP-seq
MIRT1035233	hsa-miR-3926	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035237	hsa-miR-4435	CLIP-seq
MIRT1035238	hsa-miR-4442	CLIP-seq
MIRT1035239	hsa-miR-4443	CLIP-seq
MIRT1035240	hsa-miR-4459	CLIP-seq
MIRT1035241	hsa-miR-451b	CLIP-seq
MIRT1035242	hsa-miR-4641	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT1035244	hsa-miR-4651	CLIP-seq
MIRT1035245	hsa-miR-4664-5p	CLIP-seq
MIRT1035246	hsa-miR-4696	CLIP-seq
MIRT1035247	hsa-miR-4701-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT1035249	hsa-miR-4712-3p	CLIP-seq
MIRT1035250	hsa-miR-4722-5p	CLIP-seq
MIRT1035251	hsa-miR-4728-5p	CLIP-seq
MIRT1035252	hsa-miR-4755-3p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT1035254	hsa-miR-5096	CLIP-seq
MIRT1035255	hsa-miR-545	CLIP-seq
MIRT1035256	hsa-miR-548s	CLIP-seq
MIRT1035257	hsa-miR-558	CLIP-seq
MIRT1035258	hsa-miR-570	CLIP-seq
MIRT1035259	hsa-miR-582-5p	CLIP-seq
MIRT1035260	hsa-miR-588	CLIP-seq
MIRT1035261	hsa-miR-608	CLIP-seq
MIRT1035262	hsa-miR-625	CLIP-seq
MIRT1035263	hsa-miR-650	CLIP-seq
MIRT1035264	hsa-miR-661	CLIP-seq
MIRT1035265	hsa-miR-720	CLIP-seq
MIRT1035266	hsa-miR-940	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2006916	hsa-miR-128	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035226	hsa-miR-3687	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006928	hsa-miR-377	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035238	hsa-miR-4442	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2006931	hsa-miR-4772-3p	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006933	hsa-miR-513a-5p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq
MIRT1035201	hsa-miR-101	CLIP-seq
MIRT2239455	hsa-miR-1225-3p	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2239457	hsa-miR-1233	CLIP-seq
MIRT1035203	hsa-miR-1254	CLIP-seq
MIRT2239458	hsa-miR-1273e	CLIP-seq
MIRT2006916	hsa-miR-128	CLIP-seq
MIRT1035206	hsa-miR-144	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT1035210	hsa-miR-197	CLIP-seq
MIRT2239459	hsa-miR-3065-5p	CLIP-seq
MIRT1035212	hsa-miR-3116	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035220	hsa-miR-3187-3p	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035224	hsa-miR-3663-5p	CLIP-seq
MIRT2239460	hsa-miR-3690	CLIP-seq
MIRT2239461	hsa-miR-378	CLIP-seq
MIRT2239462	hsa-miR-378b	CLIP-seq
MIRT2239463	hsa-miR-378c	CLIP-seq
MIRT2239464	hsa-miR-378d	CLIP-seq
MIRT2239465	hsa-miR-378e	CLIP-seq
MIRT2239466	hsa-miR-378f	CLIP-seq
MIRT2239467	hsa-miR-378h	CLIP-seq
MIRT2239468	hsa-miR-378i	CLIP-seq
MIRT1035233	hsa-miR-3926	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT2239469	hsa-miR-422a	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT2239470	hsa-miR-4434	CLIP-seq
MIRT1035237	hsa-miR-4435	CLIP-seq
MIRT2239471	hsa-miR-4516	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT1035247	hsa-miR-4701-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035252	hsa-miR-4755-3p	CLIP-seq
MIRT2006931	hsa-miR-4772-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2239475	hsa-miR-4797-5p	CLIP-seq
MIRT1035254	hsa-miR-5096	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT1035256	hsa-miR-548s	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT1035259	hsa-miR-582-5p	CLIP-seq
MIRT1035260	hsa-miR-588	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2239477	hsa-miR-619	CLIP-seq
MIRT1035264	hsa-miR-661	CLIP-seq
MIRT1035265	hsa-miR-720	CLIP-seq
MIRT2239478	hsa-miR-935	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT1035217	hsa-miR-3153	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT2388793	hsa-miR-4668-5p	CLIP-seq
MIRT1035248	hsa-miR-4705	CLIP-seq
MIRT2388794	hsa-miR-513a-3p	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2450812	hsa-miR-129-5p	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2450813	hsa-miR-2052	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2450815	hsa-miR-4694-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT2450816	hsa-miR-4760-3p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2450817	hsa-miR-485-3p	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2450812	hsa-miR-129-5p	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT2450813	hsa-miR-2052	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2450815	hsa-miR-4694-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2543194	hsa-miR-1283	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2543195	hsa-miR-3174	CLIP-seq
MIRT2543196	hsa-miR-3613-3p	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT2543197	hsa-miR-4269	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2543198	hsa-miR-4684-5p	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2543199	hsa-miR-4786-5p	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2543200	hsa-miR-769-5p	CLIP-seq
MIRT2543201	hsa-miR-921	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq
MIRT2006912	hsa-miR-106a	CLIP-seq
MIRT2006913	hsa-miR-106b	CLIP-seq
MIRT2239456	hsa-miR-1228	CLIP-seq
MIRT2006914	hsa-miR-1234	CLIP-seq
MIRT2006915	hsa-miR-125a-3p	CLIP-seq
MIRT2543194	hsa-miR-1283	CLIP-seq
MIRT2006917	hsa-miR-150	CLIP-seq
MIRT2006918	hsa-miR-17	CLIP-seq
MIRT1035208	hsa-miR-185	CLIP-seq
MIRT1035209	hsa-miR-1915	CLIP-seq
MIRT2006919	hsa-miR-20a	CLIP-seq
MIRT2006920	hsa-miR-20b	CLIP-seq
MIRT2006921	hsa-miR-302a	CLIP-seq
MIRT2006922	hsa-miR-302b	CLIP-seq
MIRT2006923	hsa-miR-302c	CLIP-seq
MIRT2006924	hsa-miR-302d	CLIP-seq
MIRT2006925	hsa-miR-302e	CLIP-seq
MIRT1035215	hsa-miR-3135b	CLIP-seq
MIRT1035216	hsa-miR-3149	CLIP-seq
MIRT2543196	hsa-miR-3613-3p	CLIP-seq
MIRT1035223	hsa-miR-3652	CLIP-seq
MIRT2450814	hsa-miR-3688-3p	CLIP-seq
MIRT2006926	hsa-miR-372	CLIP-seq
MIRT2006927	hsa-miR-373	CLIP-seq
MIRT2006929	hsa-miR-3934	CLIP-seq
MIRT1035234	hsa-miR-411	CLIP-seq
MIRT1035235	hsa-miR-4306	CLIP-seq
MIRT1035236	hsa-miR-4430	CLIP-seq
MIRT1035243	hsa-miR-4644	CLIP-seq
MIRT2543198	hsa-miR-4684-5p	CLIP-seq
MIRT2006930	hsa-miR-4731-5p	CLIP-seq
MIRT2239472	hsa-miR-4735-5p	CLIP-seq
MIRT1035253	hsa-miR-4768-3p	CLIP-seq
MIRT2239473	hsa-miR-4775	CLIP-seq
MIRT2543199	hsa-miR-4786-5p	CLIP-seq
MIRT2239474	hsa-miR-4794	CLIP-seq
MIRT2006932	hsa-miR-512-3p	CLIP-seq
MIRT2006934	hsa-miR-519d	CLIP-seq
MIRT2006935	hsa-miR-520a-3p	CLIP-seq
MIRT2006936	hsa-miR-520b	CLIP-seq
MIRT2006937	hsa-miR-520c-3p	CLIP-seq
MIRT2006938	hsa-miR-520d-3p	CLIP-seq
MIRT2006939	hsa-miR-520e	CLIP-seq
MIRT2006940	hsa-miR-520g	CLIP-seq
MIRT2006941	hsa-miR-520h	CLIP-seq
MIRT2006942	hsa-miR-552	CLIP-seq
MIRT2239476	hsa-miR-590-3p	CLIP-seq
MIRT2006943	hsa-miR-640	CLIP-seq
MIRT2006944	hsa-miR-764	CLIP-seq
MIRT2543200	hsa-miR-769-5p	CLIP-seq
MIRT2006945	hsa-miR-93	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	17405131
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	TAS	9215706
GO:0005515	Function	Protein binding	IPI	17405131
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	17405131
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	17405131
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IMP	23452348
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0008066	Function	Glutamate receptor activity	IMP	23452348
GO:0008066	Function	Glutamate receptor activity	TAS	9215706
GO:0009584	Process	Detection of visible light	TAS	9215706
GO:0030425	Component	Dendrite	IEA
GO:0035841	Component	New growing cell tip	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	17405131
GO:0045202	Component	Synapse	IEA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IMP	17405131
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0090280	Process	Positive regulation of calcium ion import	IMP	23452348

MIM	HGNC	e!Ensembl
604096	4598	ENSG00000113262

Protein

UniProt ID

O15303

Protein name

Metabotropic glutamate receptor 6 (mGluR6)

Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Si

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	67 → 479	Receptor family ligand binding region	Family
PF07562	NCD3G	514 → 564	Nine Cysteines Domain of family 3 GPCR	Family
PF00003	7tm_3	597 → 842	7 transmembrane sweet-taste receptor of 3 GCPR	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in melanocytes. {ECO:0000269|PubMed:23452348}.

Sequence

MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK

Sequence length

877

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Congenital stationary night blindness	Cone-rod synaptic disorder, congenital nonprogressive, Congenital stationary night blindness	rs786205249, rs80338903, rs62638214, rs62638624, rs62638202, rs62638197, rs766862238, rs267607140, rs267607141, rs62638191, rs62638193, rs62637021, rs62637027, rs104894910, rs104894911 View all (100 more)
Leber congenital amaurosis	Leber Congenital Amaurosis	rs386834252, rs386834253, rs121918165, rs62635288, rs281865192, rs137852833, rs137852834, rs137852835, rs2137919146, rs267606719, rs80044281, rs386834241, rs75895925, rs386834243, rs750962965 View all (532 more)	30718709
Myopia	Myopia, Severe myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805 View all (6 more)
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Congenital stationary night blindness, x-linked	X-Linked Csnb			ClinVar

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Amblyopia	Associate	22008250
Astigmatism	Associate	22008250
Autism Spectrum Disorder	Associate	28281572
Bipolar Disorder	Associate	22008250
Blindness	Associate	15781871
Carcinoma Renal Cell	Associate	22610075
Hereditary Sensory and Autonomic Neuropathies	Associate	32807182
Macular Degeneration	Associate	22008250
Myopia	Associate	19862333, 27034204, 37191617
Neoplasms	Associate	20061814
Night Blindness	Associate	15781871
Night blindness congenital stationary	Associate	18617546, 19578023, 19862333, 19878917, 19896109, 19896113, 22008250, 22959359, 24397708, 24715752, 31677249, 36499293
Pain	Associate	32807182
Retinal Diseases	Associate	37191617
Stargardt Disease	Associate	24397708
succinic semialdehyde dehydrogenase deficiency	Inhibit	33557678

GRM6 (glutamate metabotropic receptor 6)