Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2914
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate metabotropic receptor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRM4
Synonyms (NCBI Gene) Gene synonyms aliases	GPRC1D, MGLUR4, mGlu4
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

Show/Hide all(53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT054785	hsa-miR-1202	Immunocytochemistry, qRT-PCR, /Western blot	24908571
MIRT1035091	hsa-miR-1224-5p	CLIP-seq
MIRT1035092	hsa-miR-1321	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT1035094	hsa-miR-185	CLIP-seq
MIRT1035095	hsa-miR-28-5p	CLIP-seq
MIRT1035096	hsa-miR-3139	CLIP-seq
MIRT1035097	hsa-miR-3160-3p	CLIP-seq
MIRT1035098	hsa-miR-3605-5p	CLIP-seq
MIRT1035099	hsa-miR-4306	CLIP-seq
MIRT1035100	hsa-miR-4419a	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT1035102	hsa-miR-4510	CLIP-seq
MIRT1035103	hsa-miR-4644	CLIP-seq
MIRT1035104	hsa-miR-4728-5p	CLIP-seq
MIRT1035105	hsa-miR-4739	CLIP-seq
MIRT1035106	hsa-miR-4751	CLIP-seq
MIRT1035107	hsa-miR-4756-5p	CLIP-seq
MIRT1035108	hsa-miR-583	CLIP-seq
MIRT1035109	hsa-miR-708	CLIP-seq
MIRT1035110	hsa-miR-765	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT2006900	hsa-miR-31	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT2006901	hsa-miR-4539	CLIP-seq
MIRT2006902	hsa-miR-4680-5p	CLIP-seq
MIRT2006903	hsa-miR-4696	CLIP-seq
MIRT2006904	hsa-miR-4724-5p	CLIP-seq
MIRT1035091	hsa-miR-1224-5p	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq
MIRT2239423	hsa-miR-182	CLIP-seq
MIRT1035095	hsa-miR-28-5p	CLIP-seq
MIRT2239424	hsa-miR-3117-5p	CLIP-seq
MIRT1035096	hsa-miR-3139	CLIP-seq
MIRT1035097	hsa-miR-3160-3p	CLIP-seq
MIRT2239425	hsa-miR-3614-5p	CLIP-seq
MIRT2239426	hsa-miR-3649	CLIP-seq
MIRT2239427	hsa-miR-4456	CLIP-seq
MIRT1035101	hsa-miR-4459	CLIP-seq
MIRT2239428	hsa-miR-4648	CLIP-seq
MIRT2239429	hsa-miR-4717-5p	CLIP-seq
MIRT2239430	hsa-miR-4722-5p	CLIP-seq
MIRT2239431	hsa-miR-4733-3p	CLIP-seq
MIRT1035106	hsa-miR-4751	CLIP-seq
MIRT2239432	hsa-miR-541	CLIP-seq
MIRT1035108	hsa-miR-583	CLIP-seq
MIRT2239433	hsa-miR-603	CLIP-seq
MIRT2239434	hsa-miR-654-5p	CLIP-seq
MIRT2239435	hsa-miR-665	CLIP-seq
MIRT1035109	hsa-miR-708	CLIP-seq
MIRT2239436	hsa-miR-711	CLIP-seq
MIRT1035110	hsa-miR-765	CLIP-seq
MIRT1035093	hsa-miR-1324	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IDA	15102938
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IMP	8738157, 9473604
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	15102938
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IMP	15102938
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS	8738157
GO:0007269	Process	Neurotransmitter secretion	TAS	15102938
GO:0008066	Function	Glutamate receptor activity	IMP	8738157, 9473604
GO:0031410	Component	Cytoplasmic vesicle	IDA	15102938
GO:0043410	Process	Positive regulation of MAPK cascade	IEP	15102938
GO:0043523	Process	Regulation of neuron apoptotic process	TAS	15102938
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
604100	4596	ENSG00000124493

Protein

UniProt ID

Q14833

Protein name

Metabotropic glutamate receptor 4 (mGluR4)

Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate

PDB

7E9H , 8JD4 , 8JD5 , 8JD6 , 8WG9 , 8WGB , 8WGC , 8WGD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	77 → 484	Receptor family ligand binding region	Family
PF07562	NCD3G	516 → 566	Nine Cysteines Domain of family 3 GPCR	Family
PF00003	7tm_3	599 → 844	7 transmembrane sweet-taste receptor of 3 GCPR	Family

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}.

Sequence

MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI

Sequence length

912

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Taste transduction		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	15694259
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	11525421, 23714430, 19351574

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Asthma	Asthma		GWAS
Osteosarcoma	Osteosarcoma	Collectively, our study identifies Rad18 as a driver of OS doxorubicin resistance that promotes the HR pathway and indicates that targeting Rad18 is an effective approach to overcome chemotherapy resistance in OS.	GWAS, CBGDA
Sarcoidosis	Sarcoidosis		GWAS
Psoriasis	Psoriasis		GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	16380905
Breast Neoplasms	Associate	31492116
Breast Neoplasms	Stimulate	33318294
Carcinoma Renal Cell	Associate	30488581, 32788609
Glioma	Associate	38164693
Neoplasm Metastasis	Stimulate	24399291
Neoplasm Metastasis	Associate	24984297, 26276359
Neoplasms	Associate	20061814
Osteosarcoma	Associate	23727862, 24399291, 24984297, 26276359, 29339716
Pierre Robin Syndrome	Associate	28418932
Psychotic Disorders	Associate	16380905
Schizophrenia	Associate	16380905

GRM4 (glutamate metabotropic receptor 4)