Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29121
Gene name Gene Name - the full gene name approved by the HGNC.
C-type lectin domain family 2 member D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLEC2D
Synonyms (NCBI Gene) Gene synonyms aliases
CLAX, LLT1, OCIL
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT500165 hsa-miR-200b-3p HITS-CLIP 21572407
MIRT500164 hsa-miR-200c-3p HITS-CLIP 21572407
MIRT500163 hsa-miR-429 HITS-CLIP 21572407
MIRT500162 hsa-miR-205-3p HITS-CLIP 21572407
MIRT500161 hsa-miR-6767-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity TAS 10541800
GO:0005783 Component Endoplasmic reticulum IDA 20843815
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 10541800
GO:0007166 Process Cell surface receptor signaling pathway TAS 10541800
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605659 14351 ENSG00000069493
Protein
UniProt ID Q9UHP7
Protein name C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Protein function Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:16339513, PubMed:20843815). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates
PDB 4QKG , 4QKH , 4QKI , 4QKJ , 4WCO , 5MGT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 92 186 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and
Sequence
MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFFLIMFLTIIVCGMVAALSAIR
ANCHQEPSVCLQAACPESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELN
FLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPILGAGECAYLNDKGASSARHYTER
KWICSK
SDIHV
Sequence length 191
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
17554300
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 26147876
Carcinoma Hepatocellular Associate 39511540
Carcinoma Renal Cell Associate 29968393
Carcinoma Squamous Cell Associate 33588862
COVID 19 Stimulate 37287972
Glioma Associate 17440061, 39511540
Inflammation Associate 24352438, 39511540
Laryngeal Neoplasms Associate 28582492
Lymphoma Follicular Associate 31686194
Mouth Neoplasms Associate 28582492