Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2912
Gene name	Glutamate metabotropic receptor 2
Gene symbol	GRM2
Synonyms (NCBI Gene)	GLUR2GPRC1BMGLUR2mGlu2
Chromosome	3
Chromosome location	3p21.2
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

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miRTarBase ID	miRNA	Experiments
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2388783	hsa-miR-140-3p	CLIP-seq
MIRT2388784	hsa-miR-3944-5p	CLIP-seq
MIRT2388785	hsa-miR-4318	CLIP-seq
MIRT2388786	hsa-miR-4436a	CLIP-seq
MIRT2388787	hsa-miR-4693-5p	CLIP-seq
MIRT2388788	hsa-miR-4700-3p	CLIP-seq
MIRT2388789	hsa-miR-606	CLIP-seq
MIRT2388790	hsa-miR-892a	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2682094	hsa-miR-3926	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2682095	hsa-miR-548s	CLIP-seq
MIRT2682096	hsa-miR-617	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq

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Transcription factor	Regulation	Reference
HDAC2	Unknown	22864611

Show/Hide all (51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IBA
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	7620613
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	18297054, 25416956, 32296183, 34903715
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12011465
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7620613
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	34239069
GO:0007194	Process	Negative regulation of adenylate cyclase activity	TAS	7620613
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IDA	37286794
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IDA	37286794
GO:0007268	Process	Chemical synaptic transmission	TAS	7620613
GO:0008066	Function	Glutamate receptor activity	IDA	37286794
GO:0008066	Function	Glutamate receptor activity	IEA
GO:0008066	Function	Glutamate receptor activity	TAS	7620613
GO:0010467	Process	Gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0014048	Process	Regulation of glutamate secretion	IEA
GO:0014059	Process	Regulation of dopamine secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0033554	Process	Cellular response to stress	IEA
GO:0035095	Process	Behavioral response to nicotine	IEA
GO:0042220	Process	Response to cocaine	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0090461	Process	Intracellular glutamate homeostasis	IEA
GO:0097110	Function	Scaffold protein binding	IEA
GO:0097110	Function	Scaffold protein binding	ISS
GO:0097449	Component	Astrocyte projection	IEA
GO:0097449	Component	Astrocyte projection	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:2001023	Process	Regulation of response to drug	IEA

MIM	HGNC	e!Ensembl
604099	4594	ENSG00000164082

Q14416

Protein name

Metabotropic glutamate receptor 2 (mGluR2)

Protein function

Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits pr

PDB

4XAQ , 4XAS , 5CNI , 5CNJ , 5KZN , 5KZQ , 7E9G , 7EPA , 7EPB , 7EPD , 7MTQ , 7MTR , 7MTS , 8JCU , 8JCV , 8JCW , 8JCX , 8JCY , 8JCZ , 8JD0 , 8JD1 , 8JD2 , 8JD3 , 8JD4 , 8JD5 , 8WG9 , 8WGB , 8WGC , 8WGD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	60 → 462	Receptor family ligand binding region	Family
PF07562	NCD3G	496 → 546	Nine Cysteines Domain of family 3 GPCR	Family
PF00003	7tm_3	579 → 816	7 transmembrane sweet-taste receptor of 3 GCPR	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}.

Sequence

MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

Sequence length

872

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY, TEMPORAL LOBE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSES, SUBSTANCE-INDUCED	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	23874428	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibromyalgia	Associate	34387961	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	12614329	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	23874428	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Associate	35960497	★★★★★ ★☆☆☆☆ Found in Text Mining only

GRM2 (glutamate metabotropic receptor 2)