Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2912
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate metabotropic receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRM2
Synonyms (NCBI Gene) Gene synonyms aliases	GLUR2, GPRC1B, MGLUR2, mGlu2
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

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miRTarBase ID	miRNA	Experiments
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2388783	hsa-miR-140-3p	CLIP-seq
MIRT2388784	hsa-miR-3944-5p	CLIP-seq
MIRT2388785	hsa-miR-4318	CLIP-seq
MIRT2388786	hsa-miR-4436a	CLIP-seq
MIRT2388787	hsa-miR-4693-5p	CLIP-seq
MIRT2388788	hsa-miR-4700-3p	CLIP-seq
MIRT2388789	hsa-miR-606	CLIP-seq
MIRT2388790	hsa-miR-892a	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2682094	hsa-miR-3926	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2682095	hsa-miR-548s	CLIP-seq
MIRT2682096	hsa-miR-617	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
HDAC2	Unknown	22864611

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001640	Function	Adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	21873635
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	TAS	7620613
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	18297054, 25416956, 32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007194	Process	Negative regulation of adenylate cyclase activity	TAS	7620613
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0008066	Function	Glutamate receptor activity	TAS	7620613
GO:0010467	Process	Gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0051896	Process	Regulation of protein kinase B signaling	ISS
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA	21873635
GO:0090461	Process	Glutamate homeostasis	IEA
GO:0097110	Function	Scaffold protein binding	ISS
GO:0097449	Component	Astrocyte projection	ISS
GO:0099055	Component	Integral component of postsynaptic membrane	IEA

MIM	HGNC	e!Ensembl
604099	4594	ENSG00000164082

Protein

UniProt ID

Q14416

Protein name

Metabotropic glutamate receptor 2 (mGluR2)

Protein function

Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits pr

PDB

4XAQ , 4XAS , 5CNI , 5CNJ , 5KZN , 5KZQ , 7E9G , 7EPA , 7EPB , 7EPD , 7MTQ , 7MTR , 7MTS , 8JCU , 8JCV , 8JCW , 8JCX , 8JCY , 8JCZ , 8JD0 , 8JD1 , 8JD2 , 8JD3 , 8JD4 , 8JD5 , 8WG9 , 8WGB , 8WGC , 8WGD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	60 → 462	Receptor family ligand binding region	Family
PF07562	NCD3G	496 → 546	Nine Cysteines Domain of family 3 GPCR	Family
PF00003	7tm_3	579 → 816	7 transmembrane sweet-taste receptor of 3 GCPR	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}.

Sequence

MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

Sequence length

872

Interactions

View interactions

	KEGG		Reactome
	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Epilepsy	Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	18804094
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	18923069

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome			GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	23874428
Fibromyalgia	Associate	34387961
Glioma	Associate	12614329
Neoplasm Metastasis	Associate	23874428
Pulmonary Arterial Hypertension	Associate	35960497

GRM2 (glutamate metabotropic receptor 2)