Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29098
Gene name	RAN guanine nucleotide release factor
Gene symbol	RANGRF
Synonyms (NCBI Gene)	HSPC165HSPC236MOG1RANGNRF
Chromosome	17
Chromosome location	17p13.1
Summary	This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript vari

Show/Hide all (6)

miRTarBase ID	miRNA	Experiments
MIRT1289828	hsa-miR-2355-5p	CLIP-seq
MIRT1289829	hsa-miR-3661	CLIP-seq
MIRT1289830	hsa-miR-4751	CLIP-seq
MIRT1289831	hsa-miR-492	CLIP-seq
MIRT1289832	hsa-miR-631	CLIP-seq
MIRT1289833	hsa-miR-935	CLIP-seq

Show/Hide all (54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	TAS	21621375
GO:0003254	Process	Regulation of membrane depolarization	IEA
GO:0003254	Process	Regulation of membrane depolarization	IMP	23420830
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	28514442, 32814053, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11290418
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	ISS
GO:0005737	Component	Cytoplasm	IDA	11290418
GO:0005737	Component	Cytoplasm	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IDA	23420830
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IC	18184654
GO:0005886	Component	Plasma membrane	IEA
GO:0005901	Component	Caveola	IDA	23420830
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	23420830
GO:0014704	Component	Intercalated disc	IEA
GO:0014704	Component	Intercalated disc	ISS	18184654
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA
GO:0017080	Function	Sodium channel regulator activity	IDA	18184654
GO:0017080	Function	Sodium channel regulator activity	IEA
GO:0017080	Function	Sodium channel regulator activity	IMP	23420830
GO:0031267	Function	Small GTPase binding	IBA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031267	Function	Small GTPase binding	IPI	11290418, 29040603
GO:0031267	Function	Small GTPase binding	ISS
GO:0032527	Process	Protein exit from endoplasmic reticulum	IMP	23420830
GO:0044325	Function	Transmembrane transporter binding	IBA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0044325	Function	Transmembrane transporter binding	IPI	18184654
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060047	Process	Heart contraction	IBA
GO:0090307	Process	Mitotic spindle assembly	IMP	29040603
GO:0098905	Process	Regulation of bundle of His cell action potential	IMP	21621375
GO:0098909	Process	Regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP	21621375
GO:0099103	Function	Channel activator activity	IDA	18184654
GO:1900825	Process	Regulation of membrane depolarization during cardiac muscle cell action potential	IBA
GO:1900825	Process	Regulation of membrane depolarization during cardiac muscle cell action potential	IMP	21621375
GO:1900825	Process	Regulation of membrane depolarization during cardiac muscle cell action potential	TAS	21621375
GO:1900827	Process	Positive regulation of membrane depolarization during cardiac muscle cell action potential	IDA	18184654
GO:1902305	Process	Regulation of sodium ion transmembrane transport	IDA	18184654
GO:1902305	Process	Regulation of sodium ion transmembrane transport	IEA
GO:1902305	Process	Regulation of sodium ion transmembrane transport	IMP	21621375, 23420830
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IMP	23420830
GO:2000010	Process	Positive regulation of protein localization to cell surface	IDA	18184654
GO:2000010	Process	Positive regulation of protein localization to cell surface	IMP	23420830

MIM	HGNC	e!Ensembl
607954	17679	ENSG00000108961

Q9HD47

Protein name

Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)

Protein function

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Reg

PDB

5YFG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04603	Mog1	7 → 145	Ran-interacting Mog1 protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:21621375}.

Sequence

MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRG
EAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAK
DVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDP
NIFGPQ

Sequence length

186

Interactions

View interactions

	Reactome
			Phase 0 - rapid depolarisation

135

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cardiac arrhythmia	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs150856064, rs767541224, rs1380032341, rs200615633, rs1247874145, rs769218673, rs755244411, rs771333875, rs548428743, rs774053920, rs755816071, rs2151609934, rs140016697, rs140312984, rs2151611212 View all (109 more)	RCV001841208 RCV001841207 RCV001841210 RCV001841204 RCV001841212 RCV001841211 RCV001841214 RCV001842034 RCV001842032 RCV001842029 RCV001842031 RCV001842040 RCV001842045 RCV001842052 RCV001842049 RCV001842046 RCV001842048 RCV002046512 RCV001995316 RCV001901691 RCV001935473 RCV002055768 RCV001842432 RCV001926693 RCV001899184 RCV001874969 RCV001964616 RCV002013717 RCV002037401 RCV001971948 RCV001890009 RCV001909093 RCV001963187 RCV002098764 RCV002146391 RCV002212158 RCV002167340 RCV002215229 RCV002095360 RCV002197117 RCV002098339 RCV002147603 RCV002162496 RCV002162498 RCV002169656 RCV002171035 RCV003089175 RCV003074404 RCV003058975 RCV003077441 RCV001842510 RCV001842511 RCV001852051 RCV003079660 RCV003076211 RCV003088203 RCV003073452 RCV002620184 RCV002607629 RCV003108177 RCV002583202 RCV002594275 RCV002654220 RCV002700950 RCV002746655 RCV002771042 RCV002837996 RCV002846679 RCV002918291 RCV002933653 RCV002949066 RCV003008328 RCV003011776 RCV003033970 RCV003046265 RCV003755000 RCV001842999 RCV001843039 RCV001843040 RCV003592769 RCV003592776 RCV003592731 RCV003592733 RCV003592792 RCV003592921 RCV003591233 RCV003591153 RCV003755181 RCV003755283 RCV003755380 RCV003755496 RCV003755715 RCV003756012 RCV003756202 RCV003756436 RCV003756541 RCV003826053 RCV003834476 RCV003850216 RCV003862091 RCV003858717 RCV003851869 RCV003870511 RCV001841322 RCV002062459 RCV002063640 RCV001841338 RCV001841336 RCV002061665 RCV005090830 RCV001841345 RCV001841344 RCV005091226 RCV001841484 RCV003754880 RCV001841850 RCV001842003 RCV001841982 RCV001841986 RCV001842005 RCV002544523 RCV001842593 RCV001842596 RCV001842597 RCV001842590 RCV001841186 RCV001841187 RCV001841185 RCV001841190 RCV001841202
Glioma susceptibility 1	Uncertain significance	rs200615633	RCV005911017
RANGRF-related disorder	Likely benign	rs548428743, rs746275946	RCV003946140 RCV003911271
Thyroid cancer, nonmedullary, 1	Likely benign	rs200354447	RCV005896598
Uterine corpus endometrial carcinoma	Likely benign	rs200354447	RCV005896599

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arrhythmias Cardiac	Associate	28796037
Brugada Syndrome	Associate	26173111, 30282806, 31627867
Focal Nodular Hyperplasia	Stimulate	27600827
Growth Disorders	Associate	27600827
Hyperparathyroidism Secondary	Associate	27600827

RANGRF (RAN guanine nucleotide release factor)