Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	29098
Gene name Gene Name - the full gene name approved by the HGNC.	RAN guanine nucleotide release factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RANGRF
Synonyms (NCBI Gene) Gene synonyms aliases	HSPC165, HSPC236, MOG1, RANGNRF
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript vari

Show/Hide all(6)

miRTarBase ID	miRNA	Experiments
MIRT1289828	hsa-miR-2355-5p	CLIP-seq
MIRT1289829	hsa-miR-3661	CLIP-seq
MIRT1289830	hsa-miR-4751	CLIP-seq
MIRT1289831	hsa-miR-492	CLIP-seq
MIRT1289832	hsa-miR-631	CLIP-seq
MIRT1289833	hsa-miR-935	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	TAS	21621375
GO:0003254	Process	Regulation of membrane depolarization	IDA	18184654
GO:0003254	Process	Regulation of membrane depolarization	IMP	23420830
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	11290418
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	ISS
GO:0005737	Component	Cytoplasm	IDA	11290418
GO:0005791	Component	Rough endoplasmic reticulum	IDA	23420830
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IC	18184654
GO:0005901	Component	Caveola	IDA	23420830
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	23420830
GO:0014704	Component	Intercalated disc	ISS	18184654
GO:0017080	Function	Sodium channel regulator activity	IDA	18184654
GO:0017080	Function	Sodium channel regulator activity	IMP	23420830
GO:0031267	Function	Small GTPase binding	IPI	11290418, 29040603
GO:0031267	Function	Small GTPase binding	ISS
GO:0032527	Process	Protein exit from endoplasmic reticulum	IMP	23420830
GO:0042391	Process	Regulation of membrane potential	IDA	18184654
GO:0044325	Function	Ion channel binding	IPI	18184654
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0090226	Process	Regulation of microtubule nucleation by Ran protein signal transduction	IMP	29040603
GO:0098905	Process	Regulation of bundle of His cell action potential	IMP	21621375
GO:0098909	Process	Regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP	21621375
GO:1900825	Process	Regulation of membrane depolarization during cardiac muscle cell action potential	IMP	21621375
GO:1900825	Process	Regulation of membrane depolarization during cardiac muscle cell action potential	TAS	21621375
GO:1902305	Process	Regulation of sodium ion transmembrane transport	IDA	18184654
GO:1902305	Process	Regulation of sodium ion transmembrane transport	IMP	21621375, 23420830
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IMP	23420830
GO:2000010	Process	Positive regulation of protein localization to cell surface	IDA	18184654
GO:2000010	Process	Positive regulation of protein localization to cell surface	IMP	23420830
GO:2000649	Process	Regulation of sodium ion transmembrane transporter activity	IDA	18184654
GO:2000649	Process	Regulation of sodium ion transmembrane transporter activity	IMP	21621375, 23420830

MIM	HGNC	e!Ensembl
607954	17679	ENSG00000108961

Protein

UniProt ID

Q9HD47

Protein name

Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)

Protein function

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Reg

PDB

5YFG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04603	Mog1	7 → 145	Ran-interacting Mog1 protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:21621375}.

Sequence

MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRG
EAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAK
DVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDP
NIFGPQ

Sequence length

186

Interactions

View interactions

	Reactome
			Phase 0 - rapid depolarisation

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Atrioventricular block	First degree atrioventricular block	rs766840243, rs763809932
Brugada syndrome	Brugada Syndrome (disorder), Brugada syndrome	rs104894718, rs397514252, rs397514446, rs137854613, rs137854601, rs397514449, rs137854604, rs28937318, rs137854611, rs137854612, rs137854615, rs137854618, rs137854620, rs72554632, rs121912776 View all (97 more)	21447824, 23420830, 21621375, 24142675, 18184654, 26903377
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	27602772
Sick sinus syndrome	Sick Sinus Syndrome	rs104894488, rs1057519015, rs121908411, rs869025519, rs1057519274, rs794727637, rs1057519275, rs1057519276
Ventricular fibrillation	Ventricular Fibrillation	rs137854604, rs587782933, rs190140598

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Arrhythmias Cardiac	Associate	28796037
Brugada Syndrome	Associate	26173111, 30282806, 31627867
Focal Nodular Hyperplasia	Stimulate	27600827
Growth Disorders	Associate	27600827
Hyperparathyroidism Secondary	Associate	27600827

RANGRF (RAN guanine nucleotide release factor)