STXBP6 (syntaxin binding protein 6)

Gene

• Entrez ID: 29091
• Gene name: Syntaxin binding protein 6
• Gene symbol: STXBP6
• Synonyms (NCBI Gene): HSPC156, amisyn
• Chromosome: 14
• Chromosome location: 14q12
• Summary: STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT652998	hsa-miR-4539	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT652998	hsa-miR-4539	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT607676	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT607676	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607676	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607676	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607676	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607676	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT652998	hsa-miR-4539	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT652998	hsa-miR-4539	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607677	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT607676	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1401811	hsa-miR-128	CLIP-seq
MIRT1401812	hsa-miR-1283	CLIP-seq
MIRT1401813	hsa-miR-1323	CLIP-seq
MIRT1401814	hsa-miR-329	CLIP-seq
MIRT1401815	hsa-miR-3613-3p	CLIP-seq
MIRT1401816	hsa-miR-362-3p	CLIP-seq
MIRT1401817	hsa-miR-3941	CLIP-seq
MIRT1401818	hsa-miR-4328	CLIP-seq
MIRT1401819	hsa-miR-4753-3p	CLIP-seq
MIRT1401820	hsa-miR-4768-5p	CLIP-seq
MIRT1401821	hsa-miR-4789-3p	CLIP-seq
MIRT1401822	hsa-miR-4789-5p	CLIP-seq
MIRT1401823	hsa-miR-495	CLIP-seq
MIRT1401824	hsa-miR-548o	CLIP-seq
MIRT1401825	hsa-miR-603	CLIP-seq
MIRT2120446	hsa-miR-3148	CLIP-seq
MIRT2120447	hsa-miR-4496	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0016020	Component	Membrane	IEA
GO:0035493	Process	SNARE complex assembly	IDA	12145319
GO:0035542	Process	Regulation of SNARE complex assembly	IEA
GO:0045920	Process	Negative regulation of exocytosis	TAS	15217342
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996

Other IDs

• MIM: 607958
• HGNC: 19666
• e!Ensembl: ENSG00000168952

Protein

• UniProt ID: Q8NFX7
• Protein name: Syntaxin-binding protein 6 (Amisyn)
• Protein function: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15277	Sec3-PIP2_bind	42 → 132	Exocyst complex component SEC3 N-terminal PIP2 binding PH	Domain
  PF00957	Synaptobrevin	153 → 210	Synaptobrevin	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney. {ECO:0000269|PubMed:12145319}.
• Sequence:

  MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQA
  SITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKC
  TFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERL
  GRAEEKTEDLKNSAQQFAETAHKLAMKHKC

• Sequence length: 210