Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2905
Gene name Gene Name - the full gene name approved by the HGNC.	Glutamate ionotropic receptor NMDA type subunit 2C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRIN2C
Synonyms (NCBI Gene) Gene synonyms aliases	GluN2C, NMDAR2C, NR2C
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological proc

Show/Hide all(7)

miRTarBase ID	miRNA	Experiments
MIRT1034470	hsa-miR-298	CLIP-seq
MIRT1034471	hsa-miR-3167	CLIP-seq
MIRT1034472	hsa-miR-4786-3p	CLIP-seq
MIRT1034473	hsa-miR-876-5p	CLIP-seq
MIRT2006809	hsa-miR-1825	CLIP-seq
MIRT2006810	hsa-miR-3194-3p	CLIP-seq
MIRT2006811	hsa-miR-4502	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004972	Function	NMDA glutamate receptor activity	IBA	21873635
GO:0004972	Function	NMDA glutamate receptor activity	IDA	26919761
GO:0004972	Function	NMDA glutamate receptor activity	TAS	17526495
GO:0005515	Function	Protein binding	IPI	11937501, 30126976, 32814053
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	26875626, 26919761
GO:0007215	Process	Glutamate receptor signaling pathway	TAS	9798920
GO:0007420	Process	Brain development	NAS	17526495
GO:0009611	Process	Response to wounding	IEA
GO:0015276	Function	Ligand-gated ion channel activity	IBA	21873635
GO:0017146	Component	NMDA selective glutamate receptor complex	IBA	21873635
GO:0017146	Component	NMDA selective glutamate receptor complex	IDA	26875626, 26919761
GO:0017146	Component	NMDA selective glutamate receptor complex	TAS	17526495
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0022849	Function	Glutamate-gated calcium ion channel activity	IDA	26875626
GO:0033058	Process	Directional locomotion	IEA
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	IEA
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0042177	Process	Negative regulation of protein catabolic process	IEA
GO:0048167	Process	Regulation of synaptic plasticity	NAS	17526495
GO:0050885	Process	Neuromuscular process controlling balance	IEA
GO:0060079	Process	Excitatory postsynaptic potential	IBA	21873635
GO:0060291	Process	Long-term synaptic potentiation	IBA	21873635
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IDA	26875626
GO:0098839	Component	Postsynaptic density membrane	IBA	21873635
GO:0098976	Process	Excitatory chemical synaptic transmission	NAS	17526495
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1903539	Process	Protein localization to postsynaptic membrane	IEA
GO:1904315	Function	Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IEA

MIM	HGNC	e!Ensembl
138254	4587	ENSG00000161509

Protein

UniProt ID

Q14957

Protein name

Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)

Protein function

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in

PDB

8E92 , 8E93 , 8E94 , 8E97 , 8E98 , 8E99

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01094	ANF_receptor	98 → 288	Receptor family ligand binding region	Family
PF10613	Lig_chan-Glu_bd	401 → 539	Ligated ion channel L-glutamate- and glycine-binding site	Domain
PF00060	Lig_chan	552 → 826	Ligand-gated ion channel	Family
PF10565	NMDAR2_C	837 → 923	N-methyl D-aspartate receptor 2B3 C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancre

Sequence

MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV

Sequence length

1233

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism		Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	18033238, 24556017, 21919190, 23070074

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Alzheimer disease	Alzheimer disease	GenCC
Hyperopia	Hyperopia	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	26013316
Schizophrenia	Associate	29317596
Sleep Disorders Circadian Rhythm	Associate	33536559

GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C)