Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
28996
Gene name Gene Name - the full gene name approved by the HGNC.
Homeodomain interacting protein kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HIPK2
Synonyms (NCBI Gene) Gene synonyms aliases
PRO0593
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q34
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can fun
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005357 hsa-miR-27a-3p qRT-PCR, Western blot 20624637
MIRT005577 hsa-miR-181a-5p Immunoblot, Luciferase reporter assay, qRT-PCR 21274007
MIRT047166 hsa-miR-183-5p CLASH 23622248
MIRT046799 hsa-miR-222-3p CLASH 23622248
MIRT045503 hsa-miR-149-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
PML Activation 18809579
TP53 Activation 11740489
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001102 Function RNA polymerase II activating transcription factor binding IBA 21873635
GO:0001102 Function RNA polymerase II activating transcription factor binding ISS
GO:0001654 Process Eye development ISS 20579985
GO:0001934 Process Positive regulation of protein phosphorylation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606868 14402 ENSG00000064393
Protein
UniProt ID Q9H2X6
Protein name Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Protein function Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK
PDB 6P5S , 7NCF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 199 527 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. {ECO:0000269|PubMed:11267674, ECO:0000269|PubMed:11798164}.
Sequence
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV
TMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Sequence length 1198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cellular senescence   YAP1- and WWTR1 (TAZ)-stimulated gene expression
SUMOylation of transcription cofactors
Physiological factors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of MECP2 expression and activity
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastrointestinal stromal tumor Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Sarcoma rs587776653, rs74315368, rs74315369, rs587776793, rs587776794, rs587776795, rs606231209, rs121908589, rs121913685, rs121913680, rs794726675, rs587776804, rs121913517, rs121913234, rs121913512
View all (59 more)
27793025
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Hypertension Hypertension GWAS
Hypothyroidism Hypothyroidism GWAS
Vitiligo Vitiligo GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 21698151
Adenoma Associate 21698151
Alzheimer Disease Associate 20418953, 23330981
Arthritis Rheumatoid Associate 33964939
Astrocytoma Associate 19794125
Basal cell carcinoma infundibulocystic Associate 28607924
Breast Neoplasms Associate 17290307, 36673982
Breast Neoplasms Inhibit 22236966
Carcinogenesis Associate 22110707, 24846322, 28607924
Carcinoma Hepatocellular Associate 23792163, 28653891