Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	28969
Gene name	Basic leucine zipper and W2 domains 2
Gene symbol	BZW2
Synonyms (NCBI Gene)	5MP1HSPC028MST017MSTP017
Chromosome	7
Chromosome location	7p21.1

181

Show/Hide all (181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032241	hsa-let-7b-5p	Proteomics	18668040
MIRT045798	hsa-miR-191-5p	CLASH	23622248
MIRT734919	hsa-let-7a-5p	Luciferase reporter assayWestern blottingqRT-PCR	33273832
MIRT828036	hsa-miR-1267	CLIP-seq
MIRT828037	hsa-miR-135a	CLIP-seq
MIRT828038	hsa-miR-135b	CLIP-seq
MIRT828039	hsa-miR-147	CLIP-seq
MIRT828040	hsa-miR-218	CLIP-seq
MIRT828041	hsa-miR-3119	CLIP-seq
MIRT828042	hsa-miR-3173-3p	CLIP-seq
MIRT828043	hsa-miR-3174	CLIP-seq
MIRT828044	hsa-miR-331-5p	CLIP-seq
MIRT828045	hsa-miR-3613-3p	CLIP-seq
MIRT828046	hsa-miR-3650	CLIP-seq
MIRT828047	hsa-miR-3911	CLIP-seq
MIRT828048	hsa-miR-4294	CLIP-seq
MIRT828049	hsa-miR-4536	CLIP-seq
MIRT828050	hsa-miR-4678	CLIP-seq
MIRT828051	hsa-miR-4765	CLIP-seq
MIRT828052	hsa-miR-4790-3p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT828054	hsa-miR-548t	CLIP-seq
MIRT828055	hsa-miR-636	CLIP-seq
MIRT828056	hsa-miR-644	CLIP-seq
MIRT828057	hsa-miR-653	CLIP-seq
MIRT828058	hsa-miR-765	CLIP-seq
MIRT828059	hsa-miR-921	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828068	hsa-miR-105	CLIP-seq
MIRT828069	hsa-miR-1179	CLIP-seq
MIRT828070	hsa-miR-1236	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT828036	hsa-miR-1267	CLIP-seq
MIRT828037	hsa-miR-135a	CLIP-seq
MIRT828038	hsa-miR-135b	CLIP-seq
MIRT828039	hsa-miR-147	CLIP-seq
MIRT828041	hsa-miR-3119	CLIP-seq
MIRT828042	hsa-miR-3173-3p	CLIP-seq
MIRT828043	hsa-miR-3174	CLIP-seq
MIRT828045	hsa-miR-3613-3p	CLIP-seq
MIRT828046	hsa-miR-3650	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828073	hsa-miR-371-5p	CLIP-seq
MIRT828074	hsa-miR-371b-5p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT828047	hsa-miR-3911	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT828078	hsa-miR-3942-3p	CLIP-seq
MIRT828079	hsa-miR-4291	CLIP-seq
MIRT828048	hsa-miR-4294	CLIP-seq
MIRT828080	hsa-miR-4310	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT828083	hsa-miR-4480	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT828049	hsa-miR-4536	CLIP-seq
MIRT828086	hsa-miR-4729	CLIP-seq
MIRT828087	hsa-miR-4753-3p	CLIP-seq
MIRT828051	hsa-miR-4765	CLIP-seq
MIRT828088	hsa-miR-4768-5p	CLIP-seq
MIRT828089	hsa-miR-4775	CLIP-seq
MIRT828090	hsa-miR-4786-3p	CLIP-seq
MIRT828052	hsa-miR-4790-3p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT828091	hsa-miR-496	CLIP-seq
MIRT828092	hsa-miR-513c	CLIP-seq
MIRT828093	hsa-miR-514b-5p	CLIP-seq
MIRT828094	hsa-miR-522	CLIP-seq
MIRT828054	hsa-miR-548t	CLIP-seq
MIRT828056	hsa-miR-644	CLIP-seq
MIRT828057	hsa-miR-653	CLIP-seq
MIRT828058	hsa-miR-765	CLIP-seq
MIRT828059	hsa-miR-921	CLIP-seq
MIRT828095	hsa-miR-942	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq
MIRT1945015	hsa-miR-101	CLIP-seq
MIRT1945016	hsa-miR-197	CLIP-seq
MIRT1945017	hsa-miR-3151	CLIP-seq
MIRT1945018	hsa-miR-3180	CLIP-seq
MIRT1945019	hsa-miR-3180-3p	CLIP-seq
MIRT1945020	hsa-miR-3196	CLIP-seq
MIRT1945016	hsa-miR-197	CLIP-seq
MIRT2183495	hsa-miR-2054	CLIP-seq
MIRT1945017	hsa-miR-3151	CLIP-seq
MIRT1945018	hsa-miR-3180	CLIP-seq
MIRT1945019	hsa-miR-3180-3p	CLIP-seq
MIRT1945020	hsa-miR-3196	CLIP-seq
MIRT2183496	hsa-miR-3677-5p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT2183497	hsa-miR-520g	CLIP-seq
MIRT2183498	hsa-miR-520h	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT2487140	hsa-miR-136	CLIP-seq
MIRT2487141	hsa-miR-3121-5p	CLIP-seq
MIRT2487142	hsa-miR-3127-5p	CLIP-seq
MIRT2487143	hsa-miR-3130-3p	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT2487144	hsa-miR-3918	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT2487145	hsa-miR-4287	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT2487146	hsa-miR-4457	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT2487147	hsa-miR-4469	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT2487148	hsa-miR-4685-3p	CLIP-seq
MIRT2487149	hsa-miR-4713-5p	CLIP-seq
MIRT2487150	hsa-miR-4793-3p	CLIP-seq
MIRT2487151	hsa-miR-548aa	CLIP-seq
MIRT2487152	hsa-miR-548ac	CLIP-seq
MIRT2487153	hsa-miR-548ae	CLIP-seq
MIRT2487154	hsa-miR-548aj	CLIP-seq
MIRT2487155	hsa-miR-548am	CLIP-seq
MIRT2487156	hsa-miR-548d-3p	CLIP-seq
MIRT2487157	hsa-miR-548x	CLIP-seq
MIRT2487158	hsa-miR-548z	CLIP-seq
MIRT2487159	hsa-miR-642a	CLIP-seq
MIRT2487160	hsa-miR-671-5p	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT2487140	hsa-miR-136	CLIP-seq
MIRT2487141	hsa-miR-3121-5p	CLIP-seq
MIRT2487142	hsa-miR-3127-5p	CLIP-seq
MIRT2487143	hsa-miR-3130-3p	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT2487144	hsa-miR-3918	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT2487145	hsa-miR-4287	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT2487146	hsa-miR-4457	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT2487147	hsa-miR-4469	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT2676246	hsa-miR-450a	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT2487148	hsa-miR-4685-3p	CLIP-seq
MIRT2487149	hsa-miR-4713-5p	CLIP-seq
MIRT828090	hsa-miR-4786-3p	CLIP-seq
MIRT2487150	hsa-miR-4793-3p	CLIP-seq
MIRT2487151	hsa-miR-548aa	CLIP-seq
MIRT2487152	hsa-miR-548ac	CLIP-seq
MIRT2487153	hsa-miR-548ae	CLIP-seq
MIRT2487154	hsa-miR-548aj	CLIP-seq
MIRT2487155	hsa-miR-548am	CLIP-seq
MIRT2487156	hsa-miR-548d-3p	CLIP-seq
MIRT2487157	hsa-miR-548x	CLIP-seq
MIRT2487158	hsa-miR-548z	CLIP-seq
MIRT2676247	hsa-miR-570	CLIP-seq
MIRT2487159	hsa-miR-642a	CLIP-seq
MIRT2487160	hsa-miR-671-5p	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21745818, 25147208
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21745818, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IDA	21745818, 28981728, 29470543, 34260931
GO:0006446	Process	Regulation of translational initiation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0045296	Function	Cadherin binding	HDA	25468996

MIM	HGNC	e!Ensembl
619275	18808	ENSG00000136261

Q9Y6E2

Protein name

eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)

Protein function

Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02020	W2	338 → 415	eIF4-gamma/eIF5/eIF2-epsilon	Family

Sequence

MNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDDLEAVAKFLDSTGSRLD
YRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRNYAQVFNKLIR
RYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGNGTLPATILTSLFTDSLVKE
GIAASFAVKLFKAWMAEKDANSVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLK
ELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTC
IMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCYDNIHFMKAF
QKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN

Sequence length

419

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TUBERCULOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	38538258	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	38538258	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	37067340	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	35232999	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	36608137	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	37067340	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	37067340	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	38154691, 38538258	★★★★★ ★☆☆☆☆ Found in Text Mining only
Recurrent respiratory papillomatosis	Associate	36473368	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	38538258	★★★★★ ★☆☆☆☆ Found in Text Mining only

BZW2 (basic leucine zipper and W2 domains 2)