Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	28969
Gene name Gene Name - the full gene name approved by the HGNC.	Basic leucine zipper and W2 domains 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BZW2
Synonyms (NCBI Gene) Gene synonyms aliases	5MP1, HSPC028, MST017, MSTP017
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p21.1

Show/Hide all(181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032241	hsa-let-7b-5p	Proteomics	18668040
MIRT045798	hsa-miR-191-5p	CLASH	23622248
MIRT734919	hsa-let-7a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33273832
MIRT828036	hsa-miR-1267	CLIP-seq
MIRT828037	hsa-miR-135a	CLIP-seq
MIRT828038	hsa-miR-135b	CLIP-seq
MIRT828039	hsa-miR-147	CLIP-seq
MIRT828040	hsa-miR-218	CLIP-seq
MIRT828041	hsa-miR-3119	CLIP-seq
MIRT828042	hsa-miR-3173-3p	CLIP-seq
MIRT828043	hsa-miR-3174	CLIP-seq
MIRT828044	hsa-miR-331-5p	CLIP-seq
MIRT828045	hsa-miR-3613-3p	CLIP-seq
MIRT828046	hsa-miR-3650	CLIP-seq
MIRT828047	hsa-miR-3911	CLIP-seq
MIRT828048	hsa-miR-4294	CLIP-seq
MIRT828049	hsa-miR-4536	CLIP-seq
MIRT828050	hsa-miR-4678	CLIP-seq
MIRT828051	hsa-miR-4765	CLIP-seq
MIRT828052	hsa-miR-4790-3p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT828054	hsa-miR-548t	CLIP-seq
MIRT828055	hsa-miR-636	CLIP-seq
MIRT828056	hsa-miR-644	CLIP-seq
MIRT828057	hsa-miR-653	CLIP-seq
MIRT828058	hsa-miR-765	CLIP-seq
MIRT828059	hsa-miR-921	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828068	hsa-miR-105	CLIP-seq
MIRT828069	hsa-miR-1179	CLIP-seq
MIRT828070	hsa-miR-1236	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT828036	hsa-miR-1267	CLIP-seq
MIRT828037	hsa-miR-135a	CLIP-seq
MIRT828038	hsa-miR-135b	CLIP-seq
MIRT828039	hsa-miR-147	CLIP-seq
MIRT828041	hsa-miR-3119	CLIP-seq
MIRT828042	hsa-miR-3173-3p	CLIP-seq
MIRT828043	hsa-miR-3174	CLIP-seq
MIRT828045	hsa-miR-3613-3p	CLIP-seq
MIRT828046	hsa-miR-3650	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828073	hsa-miR-371-5p	CLIP-seq
MIRT828074	hsa-miR-371b-5p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT828047	hsa-miR-3911	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT828078	hsa-miR-3942-3p	CLIP-seq
MIRT828079	hsa-miR-4291	CLIP-seq
MIRT828048	hsa-miR-4294	CLIP-seq
MIRT828080	hsa-miR-4310	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT828083	hsa-miR-4480	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT828049	hsa-miR-4536	CLIP-seq
MIRT828086	hsa-miR-4729	CLIP-seq
MIRT828087	hsa-miR-4753-3p	CLIP-seq
MIRT828051	hsa-miR-4765	CLIP-seq
MIRT828088	hsa-miR-4768-5p	CLIP-seq
MIRT828089	hsa-miR-4775	CLIP-seq
MIRT828090	hsa-miR-4786-3p	CLIP-seq
MIRT828052	hsa-miR-4790-3p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT828091	hsa-miR-496	CLIP-seq
MIRT828092	hsa-miR-513c	CLIP-seq
MIRT828093	hsa-miR-514b-5p	CLIP-seq
MIRT828094	hsa-miR-522	CLIP-seq
MIRT828054	hsa-miR-548t	CLIP-seq
MIRT828056	hsa-miR-644	CLIP-seq
MIRT828057	hsa-miR-653	CLIP-seq
MIRT828058	hsa-miR-765	CLIP-seq
MIRT828059	hsa-miR-921	CLIP-seq
MIRT828095	hsa-miR-942	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq
MIRT1945015	hsa-miR-101	CLIP-seq
MIRT1945016	hsa-miR-197	CLIP-seq
MIRT1945017	hsa-miR-3151	CLIP-seq
MIRT1945018	hsa-miR-3180	CLIP-seq
MIRT1945019	hsa-miR-3180-3p	CLIP-seq
MIRT1945020	hsa-miR-3196	CLIP-seq
MIRT1945016	hsa-miR-197	CLIP-seq
MIRT2183495	hsa-miR-2054	CLIP-seq
MIRT1945017	hsa-miR-3151	CLIP-seq
MIRT1945018	hsa-miR-3180	CLIP-seq
MIRT1945019	hsa-miR-3180-3p	CLIP-seq
MIRT1945020	hsa-miR-3196	CLIP-seq
MIRT2183496	hsa-miR-3677-5p	CLIP-seq
MIRT828053	hsa-miR-4796-3p	CLIP-seq
MIRT2183497	hsa-miR-520g	CLIP-seq
MIRT2183498	hsa-miR-520h	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT2487140	hsa-miR-136	CLIP-seq
MIRT2487141	hsa-miR-3121-5p	CLIP-seq
MIRT2487142	hsa-miR-3127-5p	CLIP-seq
MIRT2487143	hsa-miR-3130-3p	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT2487144	hsa-miR-3918	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT2487145	hsa-miR-4287	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT2487146	hsa-miR-4457	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT2487147	hsa-miR-4469	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT2487148	hsa-miR-4685-3p	CLIP-seq
MIRT2487149	hsa-miR-4713-5p	CLIP-seq
MIRT2487150	hsa-miR-4793-3p	CLIP-seq
MIRT2487151	hsa-miR-548aa	CLIP-seq
MIRT2487152	hsa-miR-548ac	CLIP-seq
MIRT2487153	hsa-miR-548ae	CLIP-seq
MIRT2487154	hsa-miR-548aj	CLIP-seq
MIRT2487155	hsa-miR-548am	CLIP-seq
MIRT2487156	hsa-miR-548d-3p	CLIP-seq
MIRT2487157	hsa-miR-548x	CLIP-seq
MIRT2487158	hsa-miR-548z	CLIP-seq
MIRT2487159	hsa-miR-642a	CLIP-seq
MIRT2487160	hsa-miR-671-5p	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq
MIRT828060	hsa-let-7a	CLIP-seq
MIRT828061	hsa-let-7b	CLIP-seq
MIRT828062	hsa-let-7c	CLIP-seq
MIRT828063	hsa-let-7d	CLIP-seq
MIRT828064	hsa-let-7e	CLIP-seq
MIRT828065	hsa-let-7f	CLIP-seq
MIRT828066	hsa-let-7g	CLIP-seq
MIRT828067	hsa-let-7i	CLIP-seq
MIRT828071	hsa-miR-1266	CLIP-seq
MIRT2487140	hsa-miR-136	CLIP-seq
MIRT2487141	hsa-miR-3121-5p	CLIP-seq
MIRT2487142	hsa-miR-3127-5p	CLIP-seq
MIRT2487143	hsa-miR-3130-3p	CLIP-seq
MIRT828072	hsa-miR-369-3p	CLIP-seq
MIRT828075	hsa-miR-374a	CLIP-seq
MIRT828076	hsa-miR-374b	CLIP-seq
MIRT2487144	hsa-miR-3918	CLIP-seq
MIRT828077	hsa-miR-3927	CLIP-seq
MIRT2487145	hsa-miR-4287	CLIP-seq
MIRT828081	hsa-miR-4451	CLIP-seq
MIRT2487146	hsa-miR-4457	CLIP-seq
MIRT828082	hsa-miR-4458	CLIP-seq
MIRT2487147	hsa-miR-4469	CLIP-seq
MIRT828084	hsa-miR-4500	CLIP-seq
MIRT2676246	hsa-miR-450a	CLIP-seq
MIRT828085	hsa-miR-4518	CLIP-seq
MIRT2487148	hsa-miR-4685-3p	CLIP-seq
MIRT2487149	hsa-miR-4713-5p	CLIP-seq
MIRT828090	hsa-miR-4786-3p	CLIP-seq
MIRT2487150	hsa-miR-4793-3p	CLIP-seq
MIRT2487151	hsa-miR-548aa	CLIP-seq
MIRT2487152	hsa-miR-548ac	CLIP-seq
MIRT2487153	hsa-miR-548ae	CLIP-seq
MIRT2487154	hsa-miR-548aj	CLIP-seq
MIRT2487155	hsa-miR-548am	CLIP-seq
MIRT2487156	hsa-miR-548d-3p	CLIP-seq
MIRT2487157	hsa-miR-548x	CLIP-seq
MIRT2487158	hsa-miR-548z	CLIP-seq
MIRT2676247	hsa-miR-570	CLIP-seq
MIRT2487159	hsa-miR-642a	CLIP-seq
MIRT2487160	hsa-miR-671-5p	CLIP-seq
MIRT828096	hsa-miR-98	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21745818, 25147208
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21745818, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IDA	21745818, 28981728, 29470543, 34260931
GO:0006446	Process	Regulation of translational initiation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0045296	Function	Cadherin binding	HDA	25468996

MIM	HGNC	e!Ensembl
619275	18808	ENSG00000136261

Protein

UniProt ID

Q9Y6E2

Protein name

eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2)

Protein function

Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02020	W2	338 → 415	eIF4-gamma/eIF5/eIF2-epsilon	Family

Sequence

MNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDDLEAVAKFLDSTGSRLD
YRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRNYAQVFNKLIR
RYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGNGTLPATILTSLFTDSLVKE
GIAASFAVKLFKAWMAEKDANSVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLK
ELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTC
IMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCYDNIHFMKAF
QKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN

Sequence length

419

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dementia	Dementia	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	38538258
Carcinoma Squamous Cell	Associate	38538258
Colorectal Neoplasms	Associate	37067340
Inflammatory Bowel Diseases	Associate	35232999
Nasopharyngeal Carcinoma	Associate	36608137
Neoplasm Metastasis	Inhibit	37067340
Neoplasms	Stimulate	37067340
Neoplasms	Associate	38154691, 38538258
Recurrent respiratory papillomatosis	Associate	36473368
Uterine Cervical Neoplasms	Associate	38538258

BZW2 (basic leucine zipper and W2 domains 2)