Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2885
Gene name Gene Name - the full gene name approved by the HGNC.
Growth factor receptor bound protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRB2
Synonyms (NCBI Gene) Gene synonyms aliases
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosph
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001201 hsa-miR-433-3p Luciferase reporter assay, Western blot 19531230
MIRT007278 hsa-miR-378a-3p Luciferase reporter assay 23447532
MIRT022221 hsa-miR-124-3p Microarray 18668037
MIRT025255 hsa-miR-34a-5p Sequencing 20371350
MIRT025709 hsa-miR-7-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0003723 Function RNA binding HDA 22658674
GO:0005154 Function Epidermal growth factor receptor binding IPI 12577067
GO:0005168 Function Neurotrophin TRKA receptor binding IPI 15488758
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
108355 4566 ENSG00000177885
Protein
UniProt ID P62993
Protein name Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Protein function Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, p
PDB 1AZE , 1BM2 , 1BMB , 1CJ1 , 1FHS , 1FYR , 1GCQ , 1GFC , 1GFD , 1GHU , 1GRI , 1IO6 , 1JYQ , 1JYR , 1JYU , 1QG1 , 1TZE , 1X0N , 1ZFP , 2AOA , 2AOB , 2H46 , 2H5K , 2HUW , 2VVK , 2VWF , 2W0Z , 3C7I , 3IMD , 3IMJ , 3IN7 , 3IN8 , 3KFJ , 3MXC , 3MXY , 3N7Y , 3N84 , 3N8M , 3OV1 , 3OVE , 3S8L , 3S8N , 3S8O , 3WA4 , 4P9V , 4P9Z , 5CDW , 6ICG , 6ICH , 6SDF , 6VK2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 4 50 SH3 domain Domain
PF00017 SH2 60 135 SH2 domain Domain
PF00018 SH3_1 162 207 SH3 domain Domain
Sequence
Sequence length 217
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
JAK-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Thermogenesis
Neurotrophin signaling pathway
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Relaxin signaling pathway
Growth hormone synthesis, secretion and action
Alcoholism
Hepatitis C
Hepatitis B
Human cytomegalovirus infection
Human papillomavirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Choline metabolism in cancer
  PI3K Cascade
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
Spry regulation of FGF signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Regulation of actin dynamics for phagocytic cup formation
Tie2 Signaling
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
Costimulation by the CD28 family
CD28 dependent Vav1 pathway
Signal regulatory protein family interactions
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Insulin receptor signalling cascade
MET activates RAS signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
MET activates PTPN11
InlB-mediated entry of Listeria monocytogenes into host cell
MET activates RAP1 and RAC1
MET receptor recycling
Interleukin-15 signaling
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Interleukin receptor SHC signaling
Regulation of signaling by CBL
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
FCGR3A-mediated phagocytosis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21195589, 18658164
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26402252, 27449805, 32160453
Alzheimer Disease Associate 33804025
Bipolar Disorder Associate 29197740
Breast Neoplasms Associate 26458823, 40384436
Carcinogenesis Associate 10995035
Carcinoma Hepatocellular Associate 24391994, 26204832, 32298608, 34348664, 37626338
Carcinoma Non Small Cell Lung Associate 27418131, 30069987
Carcinoma Ovarian Epithelial Associate 26637171
Colorectal Neoplasms Associate 21622897, 29693170
Dementia Associate 35327643