GPT (glutamic--pyruvic transaminase)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2875
Gene name Glutamic--pyruvic transaminase
Gene symbol GPT
Synonyms (NCBI Gene)
AAT1ALTALT1GPT1SGPT
Chromosome 8
Chromosome location 8q24.3
Summary This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, play
miRNA miRNA information provided by mirtarbase database.
21
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (21)
miRTarBase ID miRNA Experiments Reference
MIRT1032467 hsa-miR-3065-3p CLIP-seq
MIRT1032468 hsa-miR-455-3p CLIP-seq
MIRT1032469 hsa-miR-4685-5p CLIP-seq
MIRT1032470 hsa-miR-551a CLIP-seq
MIRT1032471 hsa-miR-551b CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0004021 Function L-alanine:2-oxoglutarate aminotransferase activity IEA
GO:0004021 Function L-alanine:2-oxoglutarate aminotransferase activity NAS 1931970
GO:0005615 Component Extracellular space IEA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
138200 4552 ENSG00000167701
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P24298
Protein name Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)
Protein function Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00155 Aminotran_1_2 83 → 484 Aminotransferase class I and II Domain
Tissue specificity TISSUE SPECIFICITY: Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269|PubMed:11863375}.
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Arginine biosynthesis
Alanine, aspartate and glutamate metabolism
Metabolic pathways
Carbon metabolism
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids 		  Alanine metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (16)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Cervical cancer Likely benign; Benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FATTY LIVER — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FATTY LIVER, ALCOHOLIC — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Benign; Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (91)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Abnormalities Drug Induced Associate 9787188
★★★★★
★☆☆☆☆
Found in Text Mining only
Acquired Immunodeficiency Syndrome Associate 32532356
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute On Chronic Liver Failure Stimulate 34551597
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Hyperplasia Congenital Associate 19352053
★★★★★
★☆☆☆☆
Found in Text Mining only
Alcoholism Associate 37883219
★★★★★
★☆☆☆☆
Found in Text Mining only
Anodontia Associate 31725351
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 34521259
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Associate 38128411
★★★★★
★☆☆☆☆
Found in Text Mining only
Calcinosis Associate 39862807
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 24143196, 35762276, 36107005, 37904480
★★★★★
★☆☆☆☆
Found in Text Mining only