Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	286530
Gene name Gene Name - the full gene name approved by the HGNC.	P2Y receptor family member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	P2RY8
Synonyms (NCBI Gene) Gene synonyms aliases	P2Y8
Chromosome Chromosome number	X\|Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	X;Y
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromos

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1603452612	G>C	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(75)

miRTarBase ID	miRNA	Experiments
MIRT1209103	hsa-miR-103a	CLIP-seq
MIRT1209104	hsa-miR-107	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209106	hsa-miR-324-5p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209108	hsa-miR-378g	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209110	hsa-miR-4260	CLIP-seq
MIRT1209111	hsa-miR-4292	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209114	hsa-miR-4480	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209118	hsa-miR-4716-5p	CLIP-seq
MIRT1209119	hsa-miR-4722-3p	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209121	hsa-miR-4773	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209123	hsa-miR-486-3p	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq
MIRT2060061	hsa-miR-1253	CLIP-seq
MIRT2060062	hsa-miR-214	CLIP-seq
MIRT2060063	hsa-miR-3619-5p	CLIP-seq
MIRT2060064	hsa-miR-3675-5p	CLIP-seq
MIRT2060065	hsa-miR-3925-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT2060066	hsa-miR-4270	CLIP-seq
MIRT2060067	hsa-miR-4283	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT2060068	hsa-miR-4441	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT2060070	hsa-miR-4489	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT2060071	hsa-miR-4646-5p	CLIP-seq
MIRT2060072	hsa-miR-548c-3p	CLIP-seq
MIRT2060073	hsa-miR-761	CLIP-seq
MIRT2060061	hsa-miR-1253	CLIP-seq
MIRT2060064	hsa-miR-3675-5p	CLIP-seq
MIRT2288417	hsa-miR-3922-5p	CLIP-seq
MIRT2060067	hsa-miR-4283	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT2060070	hsa-miR-4489	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT2060071	hsa-miR-4646-5p	CLIP-seq
MIRT2288418	hsa-miR-4667-5p	CLIP-seq
MIRT2288419	hsa-miR-4700-5p	CLIP-seq
MIRT2288420	hsa-miR-508-5p	CLIP-seq
MIRT2288421	hsa-miR-574-3p	CLIP-seq
MIRT2392034	hsa-miR-3182	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	25274307
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25274307
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007266	Process	Rho protein signal transduction	IDA	26529257
GO:0007266	Process	Rho protein signal transduction	IMP	23241886, 31570889
GO:0016020	Component	Membrane	IEA
GO:0035589	Process	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA
GO:0045028	Function	G protein-coupled purinergic nucleotide receptor activity	IEA
GO:0160221	Process	Rho-activating G protein-coupled receptor signaling pathway	IDA	10199825, 11094164
GO:0160221	Process	Rho-activating G protein-coupled receptor signaling pathway	IDA	25274307

MIM	HGNC	e!Ensembl
300525	15524	ENSG00000182162

Protein

UniProt ID

Q86VZ1

Protein name

S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)

Protein function

G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining th

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	40 → 293	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain (PubMed:11004484, PubMed:15466006). Expressed in B cells and follicular helper T cells in germinal centers (at pr

Sequence

MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVI
FMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVE
RFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLK
WTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAA
VVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF
QLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF

Sequence length

359

Interactions

View interactions

	KEGG
	Neuroactive ligand-receptor interaction

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Multiple myeloma	multiple myeloma	rs1603452612	N/A

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Renal Cell	Associate	36360294
Celiac Disease	Stimulate	40650227
Crohn Disease	Stimulate	40650227
Hirschsprung disease type d brachydactyly	Associate	21106984
Inflammation	Associate	40650227
Klinefelter Syndrome	Associate	32959501
Leukemia Biphenotypic Acute	Associate	20378752
Lupus Erythematosus Systemic	Associate	34901992
Lymphoma Follicular	Associate	27959929
Lymphoma Large B Cell Diffuse	Associate	22343534
Philadelphia Chromosome	Associate	36076986, 37819686
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	21106984, 26018335, 27899802, 29982439, 37819686
Spondylitis Ankylosing	Stimulate	40650227

P2RY8 (P2Y receptor family member 8)